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    Sun1 Sad1 and UNC84 domain containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360773, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sun1provided by RGD
    Official Full Name
    Sad1 and UNC84 domain containing 1provided by RGD
    Primary source
    RGD:1359142
    See related
    EnsemblRapid:ENSRNOG00000001299 AllianceGenome:RGD:1359142
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Unc84a
    Summary
    Predicted to enable cytoskeleton-nuclear membrane anchor activity; identical protein binding activity; and lamin binding activity. Involved in ossification and response to mechanical stimulus. Predicted to be located in chromosome, telomeric region; cytoplasm; and nuclear inner membrane. Predicted to be part of meiotic nuclear membrane microtubule tethering complex. Predicted to be active in nuclear envelope. Orthologous to human SUN1 (Sad1 and UNC84 domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 96.1), Heart (RPKM 86.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sun1 in Genome Data Viewer
    Location:
    12q11
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (20510230..20555123, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (15396378..15441277, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (17488482..17533334, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene ArfGAP with dual PH domains 1 Neighboring gene guided entry of tail-anchored proteins factor 4 Neighboring gene uncharacterized LOC102547493 Neighboring gene dynein, axonemal, assembly factor 5 Neighboring gene protein kinase cAMP-dependent type I regulatory subunit beta Neighboring gene uncharacterized LOC103691050

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SUN-MKL1 Crosstalk Regulates Nuclear Deformation and Fast Motility of Breast Carcinoma Cells in Fibrillar ECM Microenvironment. Sharma VP, et al. Cells, 2021 Jun 19. PMID 34205257, Free PMC Article
    2. Lacunocanalicular fluid flow transduces mechanical tension stress during distraction osteogenesis. Davidson EH, et al. J Craniofac Surg, 2013 Sep. PMID 24036726
    3. Analysis of meiosis in SUN1 deficient mice reveals a distinct role of SUN2 in mammalian meiotic LINC complex formation and function. Link J, et al. PLoS Genet, 2014 Feb. PMID 24586178, Free PMC Article
    4. Accumulation of the inner nuclear envelope protein Sun1 is pathogenic in progeric and dystrophic laminopathies. Chen CY, et al. Cell, 2012 Apr 27. PMID 22541428, Free PMC Article
    5. A mammalian KASH domain protein coupling meiotic chromosomes to the cytoskeleton. Horn HF, et al. J Cell Biol, 2013 Sep 30. PMID 24062341, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SUN-MKL1 Crosstalk Regulates Nuclear Deformation and Fast Motility of Breast Carcinoma Cells in Fibrillar ECM Microenvironment.
      Title: SUN-MKL1 Crosstalk Regulates Nuclear Deformation and Fast Motility of Breast Carcinoma Cells in Fibrillar ECM Microenvironment.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94535

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cytoskeleton-nuclear membrane anchor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lamin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-membrane adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in centrosome localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within homologous chromosome pairing at meiosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within meiotic attachment of telomere to nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in meiotic attachment of telomere to nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nuclear matrix anchoring at nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ossification IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to mechanical stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of meiotic nuclear membrane microtubule tethering complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of meiotic nuclear membrane microtubule tethering complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    SUN domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007147.1 → NP_001007148.1  SUN domain-containing protein 1

      See identical proteins and their annotated locations for NP_001007148.1

      Status: PROVISIONAL

      Source sequence(s)
      BC085844
      UniProtKB/TrEMBL
      A0A8I6AQ96, Q5U2W0
      Related
      ENSRNOP00000087314.1, ENSRNOT00000109016.2
      Conserved Domains (2) summary
      pfam07738
      Location:621 → 755
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam09387
      Location:74 → 259
      MRP; Mitochondrial RNA binding protein MRP

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      20510230..20555123 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063271462.1 → XP_063127532.1  SUN domain-containing protein 1 isoform X10

      UniProtKB/TrEMBL
      A0A8I6ALL7, A6K1X3

    2. XM_063271458.1 → XP_063127528.1  SUN domain-containing protein 1 isoform X4

      UniProtKB/TrEMBL
      A0A0G2K016

    3. XM_039089559.2 → XP_038945487.1  SUN domain-containing protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K016
      Conserved Domains (4) summary
      COG1196
      Location:493 → 668
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam07738
      Location:784 → 918
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam09387
      Location:69 → 422
      MRP; Mitochondrial RNA binding protein MRP
      cd21439
      Location:560 → 613
      SUN1_cc1; coiled-coil domain 1 of SUN domain-containing protein 1 and similar proteins

    4. XM_063271466.1 → XP_063127536.1  SUN domain-containing protein 1 isoform X18

      UniProtKB/TrEMBL
      A0A8I6A5M4, A6K1X2

    5. XM_039089565.2 → XP_038945493.1  SUN domain-containing protein 1 isoform X12

      UniProtKB/TrEMBL
      A0A8I6A5M4, A6K1X2
      Conserved Domains (4) summary
      COG1196
      Location:458 → 641
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam07738
      Location:741 → 875
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam09387
      Location:93 → 380
      MRP; Mitochondrial RNA binding protein MRP
      cd21439
      Location:518 → 569
      SUN1_cc1; coiled-coil domain 1 of SUN domain-containing protein 1 and similar proteins

    6. XM_006248949.5 → XP_006249011.1  SUN domain-containing protein 1 isoform X11

      UniProtKB/TrEMBL
      A0A8I6A5M4, A0A8I6AAB7, A6K1X2
      Related
      ENSRNOP00000088736.2, ENSRNOT00000102488.2
      Conserved Domains (2) summary
      pfam07738
      Location:742 → 876
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam09387
      Location:103 → 380
      MRP; Mitochondrial RNA binding protein MRP

    7. XM_063271460.1 → XP_063127530.1  SUN domain-containing protein 1 isoform X8

      UniProtKB/TrEMBL
      A0A8I6ALL7, A6K1X3

    8. XM_006248948.5 → XP_006249010.1  SUN domain-containing protein 1 isoform X7

      UniProtKB/TrEMBL
      A0A8I6ALL7, A6K1X3
      Related
      ENSRNOP00000094861.2, ENSRNOT00000113934.2
      Conserved Domains (2) summary
      pfam07738
      Location:771 → 905
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam09387
      Location:103 → 409
      MRP; Mitochondrial RNA binding protein MRP

    9. XM_063271459.1 → XP_063127529.1  SUN domain-containing protein 1 isoform X6

      UniProtKB/TrEMBL
      A0A8I6ALL7, A6K1X3

    10. XM_006248942.5 → XP_006249004.1  SUN domain-containing protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K016, A0A8I6A5F2
      Related
      ENSRNOP00000095673.2, ENSRNOT00000114443.2
      Conserved Domains (2) summary
      pfam07738
      Location:807 → 941
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam09387
      Location:103 → 265
      MRP; Mitochondrial RNA binding protein MRP

    11. XM_006248941.5 → XP_006249003.1  SUN domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K016
      Related
      ENSRNOP00000088072.2, ENSRNOT00000118368.2
      Conserved Domains (2) summary
      pfam07738
      Location:808 → 942
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam09387
      Location:103 → 265
      MRP; Mitochondrial RNA binding protein MRP

    12. XM_063271470.1 → XP_063127540.1  SUN domain-containing protein 1 isoform X24

      UniProtKB/TrEMBL
      A0A8I6AQ96

    13. XM_006248953.5 → XP_006249015.1  SUN domain-containing protein 1 isoform X23

      UniProtKB/TrEMBL
      A0A8I6AQ96
      Related
      ENSRNOP00000045984.3, ENSRNOT00000047287.4
      Conserved Domains (2) summary
      pfam07738
      Location:650 → 784
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam09387
      Location:103 → 288
      MRP; Mitochondrial RNA binding protein MRP

    14. XM_063271469.1 → XP_063127539.1  SUN domain-containing protein 1 isoform X22

      UniProtKB/TrEMBL
      A0A8I6A5M4, A6K1X2

    15. XM_006248952.5 → XP_006249014.1  SUN domain-containing protein 1 isoform X21

      UniProtKB/TrEMBL
      A0A8I6A5M4, A6K1X2
      Conserved Domains (2) summary
      pfam07738
      Location:683 → 817
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam09387
      Location:103 → 321
      MRP; Mitochondrial RNA binding protein MRP

    16. XM_006248951.5 → XP_006249013.1  SUN domain-containing protein 1 isoform X17

      UniProtKB/TrEMBL
      A0A8I6A5M4, A6K1X2
      Conserved Domains (2) summary
      pfam07738
      Location:705 → 839
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam09387
      Location:103 → 343
      MRP; Mitochondrial RNA binding protein MRP

    17. XM_063271468.1 → XP_063127538.1  SUN domain-containing protein 1 isoform X20

      UniProtKB/TrEMBL
      A0A8I6ALL7, A6K1X3

    18. XM_063271467.1 → XP_063127537.1  SUN domain-containing protein 1 isoform X19

      UniProtKB/TrEMBL
      A0A8I6ALL7, A6K1X3

    19. XM_063271464.1 → XP_063127534.1  SUN domain-containing protein 1 isoform X15

      UniProtKB/TrEMBL
      A0A0G2K016

    20. XM_008768984.4 → XP_008767206.1  SUN domain-containing protein 1 isoform X14

      UniProtKB/TrEMBL
      A0A0G2K016
      Conserved Domains (2) summary
      pfam07738
      Location:729 → 863
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam09387
      Location:24 → 186
      MRP; Mitochondrial RNA binding protein MRP

    21. XM_063271472.1 → XP_063127542.1  SUN domain-containing protein 1 isoform X26

      UniProtKB/TrEMBL
      A0A8I6A5M4, A6K1X2

    22. XM_039089561.2 → XP_038945489.1  SUN domain-containing protein 1 isoform X9

      UniProtKB/TrEMBL
      A0A0G2K016
      Conserved Domains (4) summary
      COG1196
      Location:464 → 639
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam07738
      Location:755 → 889
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam09387
      Location:40 → 393
      MRP; Mitochondrial RNA binding protein MRP
      cd21439
      Location:531 → 584
      SUN1_cc1; coiled-coil domain 1 of SUN domain-containing protein 1 and similar proteins

    23. XM_039089560.2 → XP_038945488.1  SUN domain-containing protein 1 isoform X9

      UniProtKB/TrEMBL
      A0A0G2K016
      Conserved Domains (4) summary
      COG1196
      Location:464 → 639
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam07738
      Location:755 → 889
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam09387
      Location:40 → 393
      MRP; Mitochondrial RNA binding protein MRP
      cd21439
      Location:531 → 584
      SUN1_cc1; coiled-coil domain 1 of SUN domain-containing protein 1 and similar proteins

    24. XM_039089566.2 → XP_038945494.1  SUN domain-containing protein 1 isoform X5

      UniProtKB/TrEMBL
      A0A0G2K016, A0A8I6APF3, A6K1X6
      Conserved Domains (4) summary
      COG1196
      Location:488 → 663
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam07738
      Location:779 → 913
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam09387
      Location:64 → 417
      MRP; Mitochondrial RNA binding protein MRP
      cd21439
      Location:555 → 608
      SUN1_cc1; coiled-coil domain 1 of SUN domain-containing protein 1 and similar proteins

    25. XM_006248946.4 → XP_006249008.1  SUN domain-containing protein 1 isoform X5

      See identical proteins and their annotated locations for XP_006249008.1

      UniProtKB/TrEMBL
      A0A0G2K016, A0A8I6APF3, A6K1X6
      Conserved Domains (4) summary
      COG1196
      Location:488 → 663
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam07738
      Location:779 → 913
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam09387
      Location:64 → 417
      MRP; Mitochondrial RNA binding protein MRP
      cd21439
      Location:555 → 608
      SUN1_cc1; coiled-coil domain 1 of SUN domain-containing protein 1 and similar proteins

    26. XM_006248943.4 → XP_006249005.1  SUN domain-containing protein 1 isoform X5

      See identical proteins and their annotated locations for XP_006249005.1

      UniProtKB/TrEMBL
      A0A0G2K016, A0A8I6APF3, A6K1X6
      Conserved Domains (4) summary
      COG1196
      Location:488 → 663
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam07738
      Location:779 → 913
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam09387
      Location:64 → 417
      MRP; Mitochondrial RNA binding protein MRP
      cd21439
      Location:555 → 608
      SUN1_cc1; coiled-coil domain 1 of SUN domain-containing protein 1 and similar proteins

    27. XM_039089564.2 → XP_038945492.1  SUN domain-containing protein 1 isoform X9

      UniProtKB/TrEMBL
      A0A0G2K016
      Conserved Domains (4) summary
      COG1196
      Location:464 → 639
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam07738
      Location:755 → 889
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam09387
      Location:40 → 393
      MRP; Mitochondrial RNA binding protein MRP
      cd21439
      Location:531 → 584
      SUN1_cc1; coiled-coil domain 1 of SUN domain-containing protein 1 and similar proteins

    28. XM_063271465.1 → XP_063127535.1  SUN domain-containing protein 1 isoform X16

      UniProtKB/TrEMBL
      A0A8I6A5M4, A6K1X2
      Related
      ENSRNOP00000096888.2, ENSRNOT00000110794.2

    29. XM_063271471.1 → XP_063127541.1  SUN domain-containing protein 1 isoform X25

      UniProtKB/TrEMBL
      A0A8I6AQ96, Q5U2W0

    30. XM_063271463.1 → XP_063127533.1  SUN domain-containing protein 1 isoform X13

      UniProtKB/TrEMBL
      A0A8I6ALL7, A6K1X3

    31. XM_006248945.4 → XP_006249007.1  SUN domain-containing protein 1 isoform X5

      See identical proteins and their annotated locations for XP_006249007.1

      UniProtKB/TrEMBL
      A0A0G2K016, A0A8I6APF3, A6K1X6
      Related
      ENSRNOP00000071265.2, ENSRNOT00000089418.3
      Conserved Domains (4) summary
      COG1196
      Location:488 → 663
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam07738
      Location:779 → 913
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam09387
      Location:64 → 417
      MRP; Mitochondrial RNA binding protein MRP
      cd21439
      Location:555 → 608
      SUN1_cc1; coiled-coil domain 1 of SUN domain-containing protein 1 and similar proteins

    32. XM_063271461.1 → XP_063127531.1  SUN domain-containing protein 1 isoform X9

      UniProtKB/TrEMBL
      A0A0G2K016

    33. XM_039089562.2 → XP_038945490.1  SUN domain-containing protein 1 isoform X9

      UniProtKB/TrEMBL
      A0A0G2K016
      Conserved Domains (4) summary
      COG1196
      Location:464 → 639
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam07738
      Location:755 → 889
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam09387
      Location:40 → 393
      MRP; Mitochondrial RNA binding protein MRP
      cd21439
      Location:531 → 584
      SUN1_cc1; coiled-coil domain 1 of SUN domain-containing protein 1 and similar proteins

    34. XM_006248947.5 → XP_006249009.1  SUN domain-containing protein 1 isoform X5

      See identical proteins and their annotated locations for XP_006249009.1

      UniProtKB/TrEMBL
      A0A0G2K016, A0A8I6APF3, A6K1X6
      Conserved Domains (4) summary
      COG1196
      Location:488 → 663
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam07738
      Location:779 → 913
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam09387
      Location:64 → 417
      MRP; Mitochondrial RNA binding protein MRP
      cd21439
      Location:555 → 608
      SUN1_cc1; coiled-coil domain 1 of SUN domain-containing protein 1 and similar proteins

    35. XM_039089567.2 → XP_038945495.1  SUN domain-containing protein 1 isoform X27

      UniProtKB/TrEMBL
      A0A0G2K016
      Conserved Domains (4) summary
      COG1196
      Location:299 → 474
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam07738
      Location:590 → 724
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam09387
      Location:190 → 228
      MRP; Mitochondrial RNA binding protein MRP
      cd21439
      Location:366 → 419
      SUN1_cc1; coiled-coil domain 1 of SUN domain-containing protein 1 and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version

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