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    Dennd1c DENN domain containing 1C [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363326, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Dennd1cprovided by RGD
    Official Full Name
    DENN domain containing 1Cprovided by RGD
    Primary source
    RGD:1590869
    See related
    EnsemblRapid:ENSRNOG00000046050 AllianceGenome:RGD:1590869
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity and phosphatidylinositol phosphate binding activity. Predicted to be involved in endocytic recycling and endocytosis. Predicted to be located in centrosome and nucleoplasm. Predicted to be active in cytosol and intracellular membrane-bounded organelle. Orthologous to human DENND1C (DENN domain containing 1C). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 292.0), Spleen (RPKM 147.6) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dennd1c in Genome Data Viewer
    Location:
    9q11
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (1991035..2003330, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (1904040..1916329, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (9976015..9982349)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 member 23 Neighboring gene crumbs cell polarity complex component 3 Neighboring gene tubulin, beta 4A class IVa Neighboring gene U1 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Signal transduction meets vesicle traffic: the software and hardware of GLUT4 translocation. Klip A, et al. Am J Physiol Cell Physiol, 2014 May 15. PMID 24598362
    2. Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors. Yoshimura S, et al. J Cell Biol, 2010 Oct 18. PMID 20937701, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in endocytic recycling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in clathrin-coated vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    DENN domain-containing protein 1C
    Names
    DENN/MADD domain containing 1C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001126289.3 → NP_001119761.2  DENN domain-containing protein 1C

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      M0RBQ8
      Related
      ENSRNOP00000067003.3, ENSRNOT00000075215.4

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      1991035..2003330 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063267477.1 → XP_063123547.1  DENN domain-containing protein 1C isoform X3

    2. XM_039083937.1 → XP_038939865.1  DENN domain-containing protein 1C isoform X2

      UniProtKB/TrEMBL
      A0A8I6A937
      Related
      ENSRNOP00000089921.1, ENSRNOT00000111590.2
      Conserved Domains (4) summary
      smart00801
      Location:303 → 369
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:93 → 271
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:9 → 87
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam03154
      Location:574 → 753
      Atrophin-1; Atrophin-1 family

    3. XM_039083936.1 → XP_038939864.1  DENN domain-containing protein 1C isoform X1

      Conserved Domains (4) summary
      smart00801
      Location:325 → 391
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:93 → 293
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:9 → 87
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam03154
      Location:589 → 768
      Atrophin-1; Atrophin-1 family

    4. XM_039083938.2 → XP_038939866.1  DENN domain-containing protein 1C isoform X4

      Conserved Domains (4) summary
      smart00801
      Location:281 → 347
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:49 → 249
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:1 → 43
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam03154
      Location:552 → 731
      Atrophin-1; Atrophin-1 family

    5. XM_063267478.1 → XP_063123548.1  DENN domain-containing protein 1C isoform X5

      UniProtKB/TrEMBL
      A6KQS0

    6. XM_039083939.2 → XP_038939867.1  DENN domain-containing protein 1C isoform X7

      UniProtKB/TrEMBL
      A6KQS0
      Conserved Domains (3) summary
      smart00801
      Location:325 → 391
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:93 → 293
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:9 → 87
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    7. XM_063267479.1 → XP_063123549.1  DENN domain-containing protein 1C isoform X6

      UniProtKB/TrEMBL
      A6KQS0

    8. XM_063267480.1 → XP_063123550.1  DENN domain-containing protein 1C isoform X8

      UniProtKB/TrEMBL
      A6KQS0

    RNA

    1. XR_005488945.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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