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    Sdccag8 SHH signaling and ciliogenesis regulator SDCCAG8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305002, updated on 9-Dec-2024

    Summary

    Official Symbol
    Sdccag8provided by RGD
    Official Full Name
    SHH signaling and ciliogenesis regulator SDCCAG8provided by RGD
    Primary source
    RGD:727781
    See related
    EnsemblRapid:ENSRNOG00000004181 AllianceGenome:RGD:727781
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in several processes, including microtubule organizing center organization; neuron migration; and regulation of cilium assembly. Predicted to be located in several cellular components, including cell-cell junction; microtubule organizing center; and photoreceptor cell cilium. Predicted to be active in centriole and centrosome. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome 16 and Senior-Loken syndrome. Orthologous to human SDCCAG8 (SHH signaling and ciliogenesis regulator SDCCAG8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 47.7), Thymus (RPKM 29.2) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Sdccag8 in Genome Data Viewer
    Location:
    13q24-q25
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (91286787..91518255)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (88754521..88979363)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (94888046..95100833)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene phospholipase D family, member 5 Neighboring gene centrosomal protein 170 Neighboring gene microRNA 350 Neighboring gene uncharacterized LOC134481601 Neighboring gene AKT serine/threonine kinase 3 Neighboring gene uncharacterized LOC134481600

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Clone Names

    • MGC93052

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in centrosome cycle  
    involved_in establishment of cell polarity  
    involved_in establishment of cell polarity  
    involved_in microtubule organizing center organization  
    acts_upstream_of_or_within microtubule organizing center organization  
    involved_in neuron migration  
    acts_upstream_of_or_within neuron migration  
    involved_in regulation of cilium assembly  
    involved_in tube formation  
    involved_in tube formation  
    Component Evidence Code Pubs
    located_in cell-cell junction  
    located_in centriolar satellite  
    is_active_in centriole  
    located_in centriole  
    is_active_in centrosome  
    located_in centrosome  
    located_in ciliary basal body  
    located_in cytoplasm  
    located_in photoreceptor cell cilium  

    General protein information

    Preferred Names
    serologically defined colon cancer antigen 8
    Names
    serologically defined colon cancer antigen 8 homolog
    slinky

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177929.3 → NP_808790.2  serologically defined colon cancer antigen 8

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      F6SRB4, Q5PQY1, Q812C8
      Related
      ENSRNOP00000098292.2, ENSRNOT00000120659.2
      Conserved Domains (1) summary
      pfam15964
      Location:6 → 709
      CCCAP; Centrosomal colon cancer autoantigen protein family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      91286787..91518255
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039090807.2 → XP_038946735.1  serologically defined colon cancer antigen 8 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JZ58, A0A8I6A6Q1
      Related
      ENSRNOP00000098293.2, ENSRNOT00000120660.2
      Conserved Domains (1) summary
      pfam15964
      Location:6 → 708
      CCCAP; Centrosomal colon cancer autoantigen protein family
    2. XM_063272378.1 → XP_063128448.1  serologically defined colon cancer antigen 8 isoform X5

      UniProtKB/TrEMBL
      A0A8I6A2X0
    3. XM_039090810.2 → XP_038946738.1  serologically defined colon cancer antigen 8 isoform X10

      UniProtKB/TrEMBL
      A0A0G2JZ58
      Conserved Domains (1) summary
      pfam15964
      Location:6 → 628
      CCCAP; Centrosomal colon cancer autoantigen protein family
    4. XM_006250321.5 → XP_006250383.1  serologically defined colon cancer antigen 8 isoform X3

      UniProtKB/TrEMBL
      A0A0G2JZ58, A0A8I5ZYP1
      Related
      ENSRNOP00000098296.2, ENSRNOT00000120663.2
      Conserved Domains (1) summary
      pfam15964
      Location:6 → 707
      CCCAP; Centrosomal colon cancer autoantigen protein family
    5. XM_006250322.5 → XP_006250384.1  serologically defined colon cancer antigen 8 isoform X4

      UniProtKB/TrEMBL
      A0A0G2JUD0, A0A0G2JZ58
      Related
      ENSRNOP00000069051.2, ENSRNOT00000077995.4
      Conserved Domains (1) summary
      pfam15964
      Location:6 → 707
      CCCAP; Centrosomal colon cancer autoantigen protein family
    6. XM_063272381.1 → XP_063128451.1  serologically defined colon cancer antigen 8 isoform X11

      UniProtKB/TrEMBL
      A0A0G2JZ58
    7. XM_063272380.1 → XP_063128450.1  serologically defined colon cancer antigen 8 isoform X9

      UniProtKB/TrEMBL
      Q812C8
      Related
      ENSRNOP00000098289.2, ENSRNOT00000120656.2
    8. XM_039090812.2 → XP_038946740.2  serologically defined colon cancer antigen 8 isoform X12

      UniProtKB/TrEMBL
      A0A0G2JZ58
    9. XM_063272377.1 → XP_063128447.1  serologically defined colon cancer antigen 8 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JZ58
    10. XM_063272379.1 → XP_063128449.1  serologically defined colon cancer antigen 8 isoform X8

      UniProtKB/TrEMBL
      A0A0G2JZ58
    11. XM_063272383.1 → XP_063128453.1  serologically defined colon cancer antigen 8 isoform X12

      UniProtKB/TrEMBL
      A0A0G2JZ58
    12. XM_008769789.4 → XP_008768011.1  serologically defined colon cancer antigen 8 isoform X6

      UniProtKB/TrEMBL
      A0A8I6A2X0
      Conserved Domains (1) summary
      pfam15964
      Location:6 → 666
      CCCAP; Centrosomal colon cancer autoantigen protein family
    13. XM_039090808.2 → XP_038946736.1  serologically defined colon cancer antigen 8 isoform X7

      UniProtKB/TrEMBL
      A0A8I6A2X0
      Conserved Domains (1) summary
      pfam15964
      Location:6 → 665
      CCCAP; Centrosomal colon cancer autoantigen protein family
    14. XM_039090814.2 → XP_038946742.1  serologically defined colon cancer antigen 8 isoform X14

      UniProtKB/TrEMBL
      A0A8I6A2X0
      Conserved Domains (1) summary
      pfam15964
      Location:6 → 543
      CCCAP; Centrosomal colon cancer autoantigen protein family
    15. XM_063272384.1 → XP_063128454.1  serologically defined colon cancer antigen 8 isoform X13

      UniProtKB/TrEMBL
      A0A0G2JZ58
    16. XM_039090811.2 → XP_038946739.2  serologically defined colon cancer antigen 8 isoform X12

      UniProtKB/TrEMBL
      A0A0G2JZ58
    17. XM_063272382.1 → XP_063128452.1  serologically defined colon cancer antigen 8 isoform X12

      UniProtKB/TrEMBL
      A0A0G2JZ58
    18. XM_063272385.1 → XP_063128455.1  serologically defined colon cancer antigen 8 isoform X15

    RNA

    1. XR_010056919.1 RNA Sequence

    2. XR_010056920.1 RNA Sequence

    3. XR_005492248.2 RNA Sequence

    4. XR_005492249.2 RNA Sequence

    5. XR_005492250.2 RNA Sequence

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