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    Dnajc7 DnaJ heat shock protein family (Hsp40) member C7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303536, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dnajc7provided by RGD
    Official Full Name
    DnaJ heat shock protein family (Hsp40) member C7provided by RGD
    Primary source
    RGD:1303226
    See related
    EnsemblRapid:ENSRNOG00000017781 AllianceGenome:RGD:1303226
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    CCRP
    Summary
    Predicted to enable heat shock protein binding activity. Predicted to be involved in chaperone cofactor-dependent protein refolding. Predicted to be located in cytosol and nucleoplasm. Orthologous to human DNAJC7 (DnaJ heat shock protein family (Hsp40) member C7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 321.6), Muscle (RPKM 292.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dnajc7 in Genome Data Viewer
    Location:
    10q31
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (86018977..86055419, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (85518637..85555079, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (88498271..88533730, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene outer dynein arm docking complex subunit 4 Neighboring gene 2',3'-cyclic nucleotide 3' phosphodiesterase Neighboring gene NFKB inhibitor interacting Ras-like 2 Neighboring gene small nucleolar RNA SNORA44 Neighboring gene chromosome 10 C17orf113 homolog pseudogene Neighboring gene zinc finger protein 385C Neighboring gene uncharacterized LOC120095293

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Role of the cochaperone Tpr2 in Hsp90 chaperoning. Moffatt NS, et al. Biochemistry, 2008 Aug 5. PMID 18620420
    2. Cofactor Tpr2 combines two TPR domains and a J domain to regulate the Hsp70/Hsp90 chaperone system. Brychzy A, et al. EMBO J, 2003 Jul 15. PMID 12853476, Free PMC Article
    3. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
    4. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC105609

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables heat shock protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in chaperone cofactor-dependent protein refolding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    dnaJ homolog subfamily C member 7
    Names
    DnaJ (Hsp40) homolog, subfamily C, member 7
    cytoplasmic CAR retention protein
    cytoplasmic constitutive active/androstane receptor retention protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213625.2 → NP_998790.2  dnaJ homolog subfamily C member 7

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A6HJ46, Q75N36
      Related
      ENSRNOP00000103216.1, ENSRNOT00000134339.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      86018977..86055419 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006247311.5 → XP_006247373.1  dnaJ homolog subfamily C member 7 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K435, Q75N36
      Related
      ENSRNOP00000072889.1, ENSRNOT00000080521.3
      Conserved Domains (8) summary
      smart00028
      Location:113 → 146
      TPR; Tetratricopeptide repeats
      COG0484
      Location:465 → 554
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      sd00006
      Location:342 → 369
      TPR; TPR repeat [structural motif]
      pfam00226
      Location:466 → 533
      DnaJ; DnaJ domain
      pfam00515
      Location:379 → 412
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:112 → 177
      TPR_11; TPR repeat
      pfam13431
      Location:135 → 167
      TPR_17; Tetratricopeptide repeat
      cl00292
      Location:19 → 91
      AANH_like; Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide.

    2. XM_006247313.4 → XP_006247375.1  dnaJ homolog subfamily C member 7 isoform X4

      See identical proteins and their annotated locations for XP_006247375.1

      UniProtKB/TrEMBL
      A0A8J8XPI1, Q75N36
      Conserved Domains (4) summary
      PLN03088
      Location:197 → 297
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
      COG0484
      Location:324 → 413
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      TIGR02917
      Location:3 → 328
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:201 → 228
      TPR; TPR repeat [structural motif]

    3. XM_006247312.5 → XP_006247374.1  dnaJ homolog subfamily C member 7 isoform X2

      UniProtKB/TrEMBL
      G3V8B8, Q566E2, Q75N36
      Related
      ENSRNOP00000024321.6, ENSRNOT00000024321.8
      Conserved Domains (7) summary
      smart00028
      Location:12 → 45
      TPR; Tetratricopeptide repeats
      COG0484
      Location:364 → 453
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      sd00006
      Location:241 → 268
      TPR; TPR repeat [structural motif]
      pfam00226
      Location:365 → 432
      DnaJ; DnaJ domain
      pfam00515
      Location:278 → 311
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:11 → 76
      TPR_11; TPR repeat
      pfam13431
      Location:34 → 66
      TPR_17; Tetratricopeptide repeat

    4. XM_039086092.2 → XP_038942020.1  dnaJ homolog subfamily C member 7 isoform X4

      UniProtKB/TrEMBL
      A0A8J8XPI1, Q75N36
      Conserved Domains (4) summary
      PLN03088
      Location:197 → 297
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
      COG0484
      Location:324 → 413
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      TIGR02917
      Location:3 → 328
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:201 → 228
      TPR; TPR repeat [structural motif]

    5. XM_063269125.1 → XP_063125195.1  dnaJ homolog subfamily C member 7 isoform X3

    RNA

    1. XR_594788.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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