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    Mrm1 mitochondrial rRNA methyltransferase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363661, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Mrm1provided by RGD
    Official Full Name
    mitochondrial rRNA methyltransferase 1provided by RGD
    Primary source
    RGD:1566232
    See related
    EnsemblRapid:ENSRNOG00000027901 AllianceGenome:RGD:1566232
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1566232
    Summary
    Predicted to enable rRNA (guanosine-2'-O-)-methyltransferase activity. Predicted to be involved in rRNA modification. Predicted to be active in mitochondrial matrix. Orthologous to human MRM1 (mitochondrial rRNA methyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 51.9), Adrenal (RPKM 46.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mrm1 in Genome Data Viewer
    Location:
    10q26
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (70187842..70194785, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (69690406..69697326, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (72136241..72143075, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102553190 Neighboring gene uncharacterized LOC134480634 Neighboring gene ubiquitin-conjugating enzyme E2I, pseudogene 4 Neighboring gene dehydrogenase/reductase 11 Neighboring gene gametogenetin binding protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Assignment of 2'-O-methyltransferases to modification sites on the mammalian mitochondrial large subunit 16 S ribosomal RNA (rRNA). Lee KW, et al. J Biol Chem, 2014 Sep 5. PMID 25074936, Free PMC Article
    2. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
    3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables rRNA (guanine) methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables rRNA (guanosine-2'-O-)-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in rRNA 2'-O-methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA modification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    rRNA methyltransferase 1, mitochondrial
    Names
    mitochondrial rRNA methyltransferase 1 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108832.2 → NP_001102302.1  rRNA methyltransferase 1, mitochondrial

      See identical proteins and their annotated locations for NP_001102302.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A6HHL7, D3ZK81
      Related
      ENSRNOP00000034375.3, ENSRNOT00000030885.5
      Conserved Domains (3) summary
      COG0566
      Location:38 → 301
      SpoU; tRNA G18 (ribose-2'-O)-methylase SpoU [Translation, ribosomal structure and biogenesis]
      pfam00588
      Location:146 → 299
      SpoU_methylase; SpoU rRNA Methylase family
      pfam08032
      Location:50 → 125
      SpoU_sub_bind; RNA 2'-O ribose methyltransferase substrate binding

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      70187842..70194785 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039086490.2 → XP_038942418.1  rRNA methyltransferase 1, mitochondrial isoform X1

      Conserved Domains (1) summary
      cd18105
      Location:68 → 225
      SpoU-like_MRM1; SAM-dependent rRNA methylase related to MRM1

    2. XM_039086493.2 → XP_038942421.1  rRNA methyltransferase 1, mitochondrial isoform X4

      Conserved Domains (1) summary
      cl38912
      Location:21 → 142
      SPOUT_MTase; SPOUT superfamily of SAM-dependent RNA methyltransferases

    3. XM_039086491.2 → XP_038942419.1  rRNA methyltransferase 1, mitochondrial isoform X2

      Conserved Domains (2) summary
      TIGR00186
      Location:47 → 213
      rRNA_methyl_3; rRNA methylase, putative, group 3
      cl38912
      Location:144 → 214
      SPOUT_MTase; SPOUT superfamily of SAM-dependent RNA methyltransferases

    4. XM_039086492.2 → XP_038942420.1  rRNA methyltransferase 1, mitochondrial isoform X3

      UniProtKB/TrEMBL
      A6HHL8
      Conserved Domains (2) summary
      TIGR00186
      Location:47 → 209
      rRNA_methyl_3; rRNA methylase, putative, group 3
      cl38912
      Location:144 → 210
      SPOUT_MTase; SPOUT superfamily of SAM-dependent RNA methyltransferases
    Nucleotide Protein Strain
    Heading Accession and Version

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