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    C5l1 complement C5 like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362120, updated on 9-Dec-2024

    Summary

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    Official Symbol
    C5l1provided by RGD
    Official Full Name
    complement C5 like 1provided by RGD
    Primary source
    RGD:1308742
    See related
    EnsemblRapid:ENSRNOG00000022033 AllianceGenome:RGD:1308742
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1308742
    Summary
    Predicted to enable endopeptidase inhibitor activity. Predicted to be involved in complement activation, alternative pathway; complement activation, classical pathway; and inflammatory response. Predicted to be located in extracellular space. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 173.5) See more
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    Genomic context

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    See C5l1 in Genome Data Viewer
    Location:
    3p11
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (38799165..38818443, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (18401716..18420064, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (14273552..14291401, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene complement C5 Neighboring gene uncharacterized LOC134486354 Neighboring gene centriolin Neighboring gene RAB14, member RAS oncogene family

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in complement activation, alternative pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in complement activation, classical pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    complement C5; complement C5-like; hemolytic complement-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001430477.1 → NP_001417406.1  hemolytic complement-like precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      38799165..38818443 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039106218.2 → XP_038962146.1  complement C5-like isoform X2

      Conserved Domains (3) summary
      cd00017
      Location:190 → 243
      ANATO; Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to ...
      pfam17790
      Location:28 → 99
      MG1; Macroglobulin domain MG1
      cl19929
      Location:90 → 149
      A2M_N; MG2 domain

    2. XM_017592127.3 → XP_017447616.1  complement C5-like isoform X1

    3. XM_017592129.3 → XP_017447618.2  complement C5-like isoform X9

      UniProtKB/TrEMBL
      A6JUE4
      Related
      ENSRNOP00000082846.2, ENSRNOT00000035829.7
      Conserved Domains (3) summary
      cd00017
      Location:269 → 322
      ANATO; Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to ...
      pfam01835
      Location:134 → 228
      A2M_N; MG2 domain
      pfam17790
      Location:32 → 128
      MG1; Macroglobulin domain MG1

    4. XM_063285242.1 → XP_063141312.1  complement C5-like isoform X6

    5. XM_039106222.1 → XP_038962150.1  complement C5-like isoform X5

      Conserved Domains (2) summary
      pfam17790
      Location:32 → 100
      MG1; Macroglobulin domain MG1
      cl19929
      Location:91 → 150
      A2M_N; MG2 domain

    6. XM_039106220.1 → XP_038962148.1  complement C5-like isoform X3

      Conserved Domains (2) summary
      pfam17790
      Location:32 → 100
      MG1; Macroglobulin domain MG1
      cl19929
      Location:91 → 150
      A2M_N; MG2 domain

    7. XM_039106225.1 → XP_038962153.1  complement C5 isoform X7

      Conserved Domains (1) summary
      pfam17790
      Location:32 → 128
      MG1; Macroglobulin domain MG1

    8. XM_063285243.1 → XP_063141313.1  complement C5 isoform X8

    9. XM_039106221.1 → XP_038962149.1  complement C5 isoform X4

      UniProtKB/TrEMBL
      A6JUE5
      Conserved Domains (2) summary
      pfam17790
      Location:32 → 128
      MG1; Macroglobulin domain MG1
      cl19929
      Location:134 → 169
      A2M_N; MG2 domain

    RNA

    1. XR_005502099.1 RNA Sequence

    2. XR_010065163.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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