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type II restriction endonuclease subunit R of ThaI and similar endonucleases The PD-(D/E)XK type II restriction endonuclease ThaI cuts the target sequence CG/CG with blunt ends. It belongs to a superfamily of PDDEXK nucleases that includes diverse members such as very short patch repair (Vsr) endonucleases, archaeal Holliday junction resolvases, MutH methyl-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and FokI.
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Jiyao W et al.(2023). "The conserved domain database in 2023.",