5FTF,5FHH,5FTB,5FHD


Conserved Protein Domain Family
DEXSc_Pif1_like
?
cd18037: DEXSc_Pif1_like 
Click on image for an interactive view with Cn3D
DEAD-box helicase domain of Pif1
Pif1 and other members of this family are RecD-like helicases involved in maintaining genome stability through unwinding double-stranded DNAs (dsDNAs), DNA/RNA hybrids, and G quadruplex (G4) structures. The members of Pif1 helicase subfamily studied so far all appear to contribute to telomere maintenance. Pif1 is a member of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Links
?
Statistics
?
PSSM-Id: 350795
Aligned: 31 rows
Threshold Bit Score: 181.293
Created: 26-Jul-2017
Updated: 17-Oct-2022
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
 
ATP bindingDEAD box
Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:
  • Structure:5FHH: Human Pif1 helicase binds Mg.ADP, contacts at 4A
  • Structure:5FTB: Bacteroides sp. Pif1 helicase binds Mg.AMP-PNP, contacts at 4A
  • Comment:Walker A motif or motif I
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1      #                  ########                                                    
5FTF_A      9 EMQKIMNLiqddENNVFVTGKAGSGKTTFLKYLIEksg----knCIVAAPTGIAAINAGGVTLHSLFGipfgpitpydrl 84   Bacteroides sp. 3...
5FHH_A     11 EQAAVLRAvl-kGQSIFFTGSAGTGKSYLLKRILGslp---ptgTVATASTGVAACHIGGTTLHAFAGigsgqaplaqcv 86   human
5FTB_A      9 EMQKIMNLiqddENNVFVTGKAGSGKTTFLKYLIEksg----knCIVAAPTGIAAINAGGVTLHSLFGipfgpitpydrl 84   Bacteroides
5FHD_A      9 EMQKIMNLiqddENNVFVTGKAGSGKTTFLKYLIEksg----knCIVAAPTGIAAINAGGVTLHSLFGipfgpitpydrl 84   Bacteroides sp. 2...
BAJ68857    8 DAKALAMLse-pQGVSFLTGKAGTGKSTLVNHWRStla---prnTLTLAPTGIAALNVNGTTIHRFIHakpgvtpaeaar 83   Bifidobacterium l...
Q6MHJ5     36 EQASALDLlr-sGENVFLTGGAGSGKSFLIRQFMReld---pkeMPILASTGAAAVLLGGRTFHSFFGlgimeggadaty 111  Bdellovibrio bact...
CBH17662  284 EQEKVINLal-kGHLMYIGGSAGTGKTVLLRALCRrmqa-eglrVAMTATTGVAGCHIGGSTFHHAMGvsaqgdfv---- 357  Trypanosoma bruce...
Q381V6    108 EKRRALTLvl-dGAPLFIGGGAGVGKSYMIQSIVTalra-kdldVVVTASTGIAALNIGGSTFHSTFGvrvtsvgnsetn 185  Trypanosoma bruce...
Q38CE9    237 DQIVATRLvc-tGSNVFITGSAGTGKTEWLLHLVRnvlp-rddrTVVTASTGMSARLLGGCTIHSFAGigrgeggfnrvy 314  Trypanosoma bruce...
CBH13377  246 EQQRALRLal-kGRNLFITGGAGSGKSLLIREIVYqlrhnkrrcVYVTATTGVAALNVRGSTVNSFAGvkfgdgdarqll 324  Trypanosoma bruce...

Feature 1                            #                                         #              
5FTF_A     85 en---kfseykvecllkmELLIIDEISMVRpDILDTIDRKlrwvyes--depfggVQVIMFGDLFQLPPVtkkqereils 159  Bacteroides sp. 3...
5FHH_A     87 al---aqrpgvrqgwlncQRLVIDEISMVEaDLFDKLEAVaravrqq--nkpfggIQLIICGDFLQLPPVtkgsqpprfc 161  human
5FTB_A     85 en---kfseykvelllkmELLIIDEISMVRpDILDTIDRKlrwvyes--depfggVQVIMFGDLFQLPPVtkkqereils 159  Bacteroides
5FHD_A     85 en---kfseykvelllkmELLIIDEISMVRpDILDTIDRKlrwvyes--depfggVQVVMFGDLFQLPPVtkkqereils 159  Bacteroides sp. 2...
BAJ68857   84 k----grenardplyrmlGAIVIDEVSMVRaDLMDCLDRFlqgargd--grpfggLRTILVGDLAQLPPVvderredaaf 157  Bifidobacterium l...
Q6MHJ5    112 er--askdkrlmsrlrkvEGVIIDEISMIP-GQALMIAEAlsqrare-sklpwggMRVIAVGDFAQLPPVthtgqrdwcf 187  Bdellovibrio bact...
CBH17662  358 ----------rknhllsyDAIIIDEVSMLPkKMFEEFDRVlreeaga-pdvpfggVQIILCGDFLQLGVIneppiihs-- 424  Trypanosoma bruce...
Q381V6    186 escavsilrysksllakvDVIVVDEVSLLHaRHLEGLDIAargapgriphlpfggIQVILCGDFMQLMHStenctsqdgg 265  Trypanosoma bruce...
Q38CE9    315 nr--vkskpevvrawrqcQTLIIDEIGNISpDTFSMIDEIarslrga-pekpfggIQVILLGDFLQLPPVdspkarnewt 391  Trypanosoma bruce...
CBH13377  325 kw--vrrsrraagrwrycQTLIIDEISMMDpLLLDKLDVIarairrr--nepfggIQVILCGDFLQLPPIpprnkpqqkt 400  Trypanosoma bruce...

Feature 1                                                                                   
5FTF_A    160 dfydg-------------------------------------------------ffffnalvfkrtgfHIVELTKIFR 188  Bacteroides sp. 3_1_23
5FHH_A    162 f---------------------------------------------------------qskswkrcvpVTLELTKVWR 182  human
5FTB_A    160 dfydg-------------------------------------------------ffffnalvfkrtgfHIVELTKIFR 188  Bacteroides
5FHD_A    160 dfydg-------------------------------------------------ffffnalvfkrtgfHIVELTKIFR 188  Bacteroides sp. 2_1_16
BAJ68857  158 rpggqwdg------------------------------------------pwffqshaiarlldkgllAGVALARVHR 193  Bifidobacterium lon...
Q6MHJ5    188 ----------------------------------------------------------lngvwevsgfQTVMLSHNQR 207  Bdellovibrio bacter...
CBH17662  425 -------------------------------------------------------------ttfrekfVKIRLETQVR 441  Trypanosoma brucei ...
Q381V6    266 gdagnkigyrgdettentagqnrsdvsstaavtdqghimsavknicvgerqrtssglifesplfltclLHLQLCEVKR 343  Trypanosoma brucei ...
Q38CE9    392 ngndtdtdsn--------------------------------------pipgklkwcfetatweslklALVGFRKSYR 431  Trypanosoma brucei ...
CBH13377  401 eenaeaqeggdpt--------------------------------dgtpapsklqycfetstwtslnlITVILHKKFR 446  Trypanosoma brucei ...

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap