Conserved Protein Domain Family
RF_mod_PrmC
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TIGR03534: RF_mod_PrmC 
protein-(glutamine-N5) methyltransferase, release factor-specific
Members of this protein family are HemK (PrmC), a protein once thought to be involved in heme biosynthesis but now recognized to be a protein-glutamine methyltransferase that modifies the peptide chain release factors. All members of the seed alignment are encoded next to the release factor 1 gene (prfA) and confirmed by phylogenetic analysis. SIMBAL analysis (manuscript in prep.) shows the motif [LIV]PRx[DE]TE (in Escherichia coli, IPRPDTE) confers specificity for the release factors rather than for ribosomal protein L3. [Protein fate, Protein modification and repair]
Links
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Statistics
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PSSM-Id: 274634
Aligned: 128 rows
Threshold Bit Score: 192.299
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
WP_014342246  33 DADLILSKLLAKPRAWILAHQQDEIASVA-HEFKRLVHLRCRGR-ALAYLTREKEFFGLRFRVTRATLIPKPDTELLVE- 109 Treponema pallidum
WP_011076892  36 ELILFNSKIIE-NSSDIFFEKDTEIDFEY-KKILKQLNKVLNKNiPVQYITKSFSFYGLSFFIKKGCFVPRQETEYMLD- 112 Mycoplasma pene...
WP_013456388   3 TISDLLLEKKRYGLKQEISDLELEKIEQGy---------------PIQYIMGYVEYANVRINLNHNVLIPRYETEELVFi 67  Mycoplasma bovis
WP_011264709   3 TIEDLLKEKRRYKLKEEISEKELKMLNLNf---------------PIQKIMGFIEMQNVIVHVNHFVLIPRYETEELIL- 66  Mycoplasma mobile
WP_011166353  23 DVYHILEHIINKDYQWIISNLDHKLTKKQiYKIDQILDLLKQNY-PLAYILKSKYFYSNIFFVNKDVLIPRNESELIID- 100 Mycoplasma myco...
WP_011283344   1 MINELKREKRKYGLSENLTQKELNLLSKNy---------------PIQKIIGHVEMLNVKIDLSYKVLIPRYETEEVIL- 64  Mycoplasma syno...
WP_010924910   3 SIDDLILEKRRYNLNNKISQKEKRLLKKNm---------------PVQKIIGYIEMANVKIDICHKVLIPRYETEELIF- 66  Mycoplasma pulm...
WP_011183529  37 DAIEIISFITKIEYSEVLFSQEKVLNKKQfKKIIKISKKLAKGK-PLAYILGYKIFRTHKILVNKNTLIPRMETELIVD- 114 Mesoplasma florum
WP_020835579   6 RKLELLKEKQRYNLPLKISKLENLKLELDy---------------PIQKIIGFIEMEGVKIFLDQKVFIPRYETQELIL- 69  Mycoplasma hyop...
WP_012498145   3 DKHILLREKERYNLPLEISNKELKLLKKDc---------------PVQKIIGYQEMQNVFIDLSYKVLIPRYETEELII- 66  Mycoplasma arth...

WP_014342246 110 SVLAHVasqmmkPRSVsvhkdtsalpvlKIFEACTGCGCIAIALMHMLrargtPPLYVIASDICMRALAVARYNARR-LL 188 Treponema pallidum
WP_011076892 113 WAVKQKk----lIDKK------------YILDLCSGSGVLANTISYIKk---nKDAIVIGVEKNRTPYKVGVKNQRN-LK 172 Mycoplasma pene...
WP_013456388  68 LLKEYL------KPGM------------KVLDLCTGSGFIGLALKKNL-----NSIRLTLSDIDSEAILQTKENAILnFG 124 Mycoplasma bovis
WP_011264709  67 EAYKYL------ENNNn----------lDVLDLCSGSGFIALAIKKHF-----PKINVMASDISEESIRQIQENVAI-NN 124 Mycoplasma mobile
WP_011166353 101 HVSEFV------KNNNd----------lLIVDLCTGSGCLGISCALLN-----DQNKVILTDISYKSLKVANKNIKK-FN 158 Mycoplasma myco...
WP_011283344  65 KAFEYI------KNDSs----------fKVLDLATGSGFIALAIKKKF-----SSAKIYASDISKIALRQASKNAQI-NK 122 Mycoplasma syno...
WP_010924910  67 LVKDFL------KDDM------------KVLDLCAGSGFIGIALSKM------KKIDLTLSDISLEAIKQIEKNVKI-NN 121 Mycoplasma pulm...
WP_011183529 115 YVNEFI------NSQNek---------iSVLDLCCGSGCIGISIAIENk---dKMENVTFSDISKKALNITSKNIEN-NN 175 Mesoplasma florum
WP_020835579  70 KIKKVI------KKGD------------LVLDLCSGSGFIGLALAKF------INAKITLADISDEAILQAKLNAKY-NN 124 Mycoplasma hyop...
WP_012498145  67 SSYQYL------NKNS------------KVLDLGCGSGFIGLAIKKN------IGCYVTLVDISKQAIKQSELNAKL-NN 121 Mycoplasma arth...

WP_014342246 189 DVSansrVRFVHADVrapipfF----SPSegtdvvqERGVcvpYDVICANPPYVPsAQARALLQDGR-GEPLGALDGGAD 263 Treponema pallidum
WP_011076892 173 LK-----TQFIKSDI------FkidrSHY---------EK---CDFIICNPPYID-KNDPNVDPSTK-CEPKQALFAPQN 227 Mycoplasma pene...
WP_013456388 125 NDEn---IEIVQSDC------F----KDI--------TGK---FDVIVSNPPYLT-YDDKDVDESVSkFEPAIALFSPDS 179 Mycoplasma bovis
WP_011264709 125 LD-----IFFLKSDL------F----EKI--------EKK---FDLIVSNPPYLS--HKNVLDESVSkYEPHLALFAKKE 176 Mycoplasma mobile
WP_011166353 159 LIN----TSCLNGNF------I----DVLi-----kNNLK---ANLIICNPPYID-INDQNIDKNVIdFEPSIALFAPNK 215 Mycoplasma myco...
WP_011283344 123 LD-----IGLIHSNW------F----SNV--------NQK---FNLIICNPPYIG--KYEELSESIKkYEPKKALYAKDD 174 Mycoplasma syno...
WP_010924910 122 VKN----YKIIQSDL------F----ENI--------QGD---FDIIVSNPPYLS--YEQKIDKSVKfFEPLKALYAPKN 174 Mycoplasma pulm...
WP_011183529 176 LVNw---TKVVKSDF------L----NSIi-----kQQNK---FNILVCNPPYID-FNDVDVDKMTKkYEPKLALFAKDN 233 Mesoplasma florum
WP_020835579 125 LE-----LNIIKSDL------F----ANI-------PEQK---FNIIVANPPYLK---EEKLANSVLnFEPKTALFAWPE 176 Mycoplasma hyop...
WP_012498145 122 LD-----VKIIKSNW------F----SNVk------NDER---FDVIVSNPPYLN---RKNHFAKSLsYEPKIALFAKKS 174 Mycoplasma arth...

WP_014342246 264 GLDLVRAFAHHSAAAL--KEGGCVFCEVGSNHAQRAARIFQA-AG-FA-TVKISKDLSGKERLIS 323 Treponema pallidum
WP_011076892 228 GYYFYFRFLSEIYPIL--ANGTEIIFEIGFNQKEEIEKFLIK-NN-IT-VFKFLKDLDDKDRVLY 287 Mycoplasma penetrans
WP_013456388 180 GWYFYEKILNEAKTYL--NEGGILAFEINPKHIFKWEKIP----G-----VRILKDMSKKDRFVF 233 Mycoplasma bovis
WP_011264709 177 GFEIIEKIIFSAKKFL--KSNGVLLLEIDTDKVKFINKID------FI-QVSYLKDINNKTRIAK 232 Mycoplasma mobile
WP_011166353 216 GLYFYEILIKNIDKIVdtNKNFLIVLEFGWLQKDSIEQLLIN-NC-LKyKWEFKKDYNDYwrnli 278 Mycoplasma mycoides
WP_011283344 175 GFYFYKKIISQAPKYL--QNEKLLIFELSALHLDKWNEIKNQkVKyNInSITFFNDIANLLRIAI 237 Mycoplasma synoviae
WP_010924910 175 GWYFYEKIIEKASSFL--KKDGMLFFEINPLHKEL---FLEK-------NFKVIKDINGKNRFAF 227 Mycoplasma pulmonis
WP_011183529 234 GLFFYKEAIKNIDKFMdiTKNILIVFEIGWKQEKELDVFLKQeLG-LKyKWKFEKDYFNNlryli 297 Mesoplasma florum
WP_020835579 177 PFSFYEKILEKIDNFL--ADDGWIFFEIDYNS----QDFFKKnYP----DFIIEKDINGKTRFAY 231 Mycoplasma hyopneumoniae
WP_012498145 175 GLFSYMQILKKAKNYL--NESGKLIFEIDQNSA----IFLKQnYP----KVIVKKDINGKDRIAI 229 Mycoplasma arthritidis
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