1TMX


Conserved Protein Domain Family
1,2-HQD
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cd03461: 1,2-HQD 
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Hydroxyquinol 1,2-dioxygenase (1,2-HQD) catalyzes the ring cleavage of hydroxyquinol (1,2,4-trihydroxybenzene), a intermediate in the degradation of a large variety of aromatic compounds including some polychloro- and nitroaromatic pollutants, to form 3-hydroxy-cis,cis-muconates. 1,2-HQD blongs to the aromatic dioxygenase family, a family of mononuclear non-heme intradiol-cleaving enzymes.
Links
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Statistics
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PSSM-Id: 239544
Aligned: 26 rows
Threshold Bit Score: 411.243
Created: 23-Jan-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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active sitedimer interface
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1TMX; Pimelobacter Hydroxyquinol 1,2-Dioxygenase
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                             #       
1TMX_B     14 QDLVERVLRSFDatadPRLKQVMQALTRHLHAFLREVRLTEAEWETGIGFLTDAGHvtn---erRQEFILLSDVLGASMQ 90  Pimelobacter simplex
XP_955806  38 QSLIDQVIAATGpkahPRLAQIMPSLVRHLHDFAREVNLTVPEWKAAVDMLNECGQisn---drRNETQLLCDILGLESL 114 Neurospora crassa ...
XP_722784   3 QAFTESVKTSLGpnatPRAKKLIASLVQHVHDFARENHLTTEDWLWGVDFINRIGQmsd---srRNEGILVCDIIGLETL 79  Candida albicans S...
EAL87388    8 PNFTDNVINAMGpktnPRFRKVMASLIRHVHDFARENELTVDEWMAGVKLLNWAGQmsd---dkRNEGQLVCDVIGLESL 84  Aspergillus fumiga...
XP_761733  20 TKLCQDVSGPNAn---PRAKFVLDSLMKHLHLFAREVQLTNEEWLGACDLLIRSGQmsd---drRNELILISDVLGLESL 93  Ustilago maydis 521
XP_957687   8 PNFTQNVIDGMGpnttPRNRQVLGALIRHIHDFAREVELTMDEWMAGVKYINEVGRvysesgqtRNEAHRLSDILGLETL 87  Neurospora crassa ...
AAQ87516    7 SDLTAAVLAVMNrteePRLREILVAMVKHLHAFVREVRLTEVEFREATAMLNEIGKlht---dqHNEFVLMAGSLGVSSL 83  Rhizobium sp. NGR234
CAG86407    3 QGFTDYVITSMGpkttPKARRILSSLIQHIHDFTRENNITVDEWMYGVELVNSIGQisd---akRNEGILVSDVIGLEAL 79  Debaryomyces hanse...
EAA73231   23 QAFTQQVIDSFGpktdPRLRELMSSFIQHMHDFARETQLTCDEWMTAVNMINWAGQmst---dkRNEGQLMCDVIGLESL 99  Gibberella zeae PH-1
EAA71175   19 PNFTDHVIGLMSpetePRQREILTSLIRHMHDFCREVELKQEEWIIGVNYINSLGQayk---knRNETWRVCDILGIESL 95  Gibberella zeae PH-1

Feature 1                                     ##                                              
1TMX_B     91 TIAMNneah-------------gdaTEATVFGPFFVEGSPRIEsGGDIAg----------GAAGEPCWVEGTVTDTDGNP 147 Pimelobacter simplex
XP_955806 115 VDEITsnlla----------ssnagTPSAVLGPFYRYNAPLLPnGSSIVknltpetpwfsQAIADSAYITGRVLSTGGRP 184 Neurospora crassa ...
XP_722784  80 VDALTnese------------qsnhTSSAILGPFYLPDSPVYPnGGSIVqk--------aIPTDVKCFVRGKVTDTEGKP 139 Candida albicans S...
EAL87388   85 VDEITfklade---------aadapTATAILGPFFRADTPYRNnGDNIVk---------dVPDGEMVFMHGRVIDFQTKK 146 Aspergillus fumiga...
XP_761733  94 VDSMAyeraqssscsaqkveggveaTQSAILGPFYRTGAPEYAnGSDIVldhni--ksseGKVGETCYMHGRVTDAATGQ 171 Ustilago maydis 521
XP_957687  88 VDEIAhkivve---------eglepTSSSILGPFWSPNAPFREnGGSIIqd-------gvPPKGRVTKMHGVIRDITTGK 151 Neurospora crassa ...
AAQ87516   84 VCLLNngdr------------gqteTSQSLLGPFWRLNSPRVEnGGSIIr---------sETPGTPLFVHGKVVDRDGKP 142 Rhizobium sp. NGR234
CAG86407   80 VDTLThssd------------tvdhTSSAIIGPFYREDSPEYPkGGSVIq---------kDVGGEKTFVSGRITDTVGNP 138 Debaryomyces hanse...
EAA73231  100 VDDIThrqavk---------ngfsgTETAILGPFWRQDTPIREnGTTITfd-------tpSDGKVAYLYGTVTSATTGKP 163 Gibberella zeae PH-1
EAA71175   96 VDEINhkvvte---------ggkapTSSSILGPFWSPETPFRDlGGSVVqd--------mPKDGQLTFFHGVIRDVDTGK 158 Gibberella zeae PH-1

Feature 1                      #                                  #                    #  # # 
1TMX_B    148 VPD-ARIEVWEADDDGFYDVQYddd--rtAARAHLLSGPDGGYAFWAITPTPYPIPHDGPVGRMLAATGRSPMRASHLHF 224 Pimelobacter simplex
XP_955806 185 IPG-AIVDTWLAAPNGLYEQQDesq-tdmNLRGRFKTDQDGRFAFYALRPTSYPIPFDGPAGRFLTLLDRNPNRPGHIHF 262 Neurospora crassa ...
XP_722784 140 LGG-AQLEVWQCNSAGFYSQQAdhdgpefNLRGTFITDDEGNYSFECLRPTSYPIPYDGPAGDLLKIMDRHPNRPSHIHW 218 Candida albicans S...
EAL87388  147 PLVgATVEVWQASTNGLYEQQDpnq-eefNLRGKFKTDADGRYYFYCLRPTPYPVPNDGPAGKLLELMDRHPFRPAHIHI 225 Aspergillus fumiga...
XP_761733 172 PVVgAKIDVWHTGPNGLYEQQDpaq-pdfNYRGKFTTDANGEYALRCLRPTAYPIPYDGGAGDILKLLDRSPMRPAHIHL 250 Ustilago maydis 521
XP_957687 152 PIPnAVFDIWQASANGKYDFQDpqnqtpnNLRGKFKANEKGEYWFYCLHPTAYSLPTDGPSYALLQLMDRHPMRPAHIHI 231 Neurospora crassa ...
AAQ87516  143 IAG-AEVDVWHASPVGLYENQDpdq-aemNLRGKFRTDEQGRFWFRTVKMVGYPIPVDGVVGRLLKAQGRHPYRPAHLHA 220 Rhizobium sp. NGR234
CAG86407  139 LPG-VKVEVWHCAPNGLYEQQDpdq-peyNLRGTFYSDEDGYYAFVGLRPTAYPIPYDGPAGKLLQVMDRHPMRPGHIHW 216 Debaryomyces hanse...
EAA73231  164 IPN-ASVDVWQASTNGLYEQQDdkq-vehNLRGKFITDDQGRYSFYCLRPTPYPVPQDGPAGKLLQKLDRHVFRPAHLHF 241 Gibberella zeae PH-1
EAA71175  159 GIPnAVFDMWQASTNGKYDAHDpenqsrhNLRGKFRTDQDGKFWFYCLKPTEYAIDTSGPSAELLRIMGRHPYRPAHIHI 238 Gibberella zeae PH-1

Feature 1                                                                        
1TMX_B    225 MVTAPGRRTLVTHIFVEGDELLDRDSVFGVKDSLVKSFERqpagaptpggreidgpWSRVRFDIVLA 291 Pimelobacter simplex
XP_955806 263 VVSAPRHRPLTTQIFDSRDKYLTEDAVFAVKDELVVKFLPhkgd---------skaRWYLEYDFVLS 320 Neurospora crassa N150
XP_722784 219 RVSHPGYHTLITQIYDAECPYTNNDSVYAVKDDIIVHFEKvdnkdk----dlvgkvEYKLDYDISLA 281 Candida albicans SC5314
EAL87388  226 IATHDGYKPLTTQIFDRQDKYLTNDSVFAVKDSLIVDFVPrkdd---------pqaGLELEYDVKLV 283 Aspergillus fumigatus Af293
XP_761733 251 LIEANGYKQLVTQIFDSKCDYIGADAVFADKSALTVDFAQptseq------akksgSQTEVTYDIRL 311 Ustilago maydis 521
XP_957687 232 MVTHPEYQGCTTQLYPSDDPWITNDTVFAVKDDLVVTFKPiegd---------ekaVLELEYNVNLA 289 Neurospora crassa N150
AAQ87516  221 LIFKHGYKTLISQVFDPSDPNIDSDVQFGVTAALTGDFIRhedphpt--eadipgpWFSLDYTYVME 285 Rhizobium sp. NGR234
CAG86407  217 RVTHPEYHSLITQIYDRECKYTADDSVFAVKDDIIVDFIPakkel------kekgiQNELHYDIALT 277 Debaryomyces hansenii CBS767
EAA73231  242 MVIAKGYNSVVTQIFDSDSGYLDNDSVFAVKDNLTVTFVPrkgd---------pqaEWELEYNMTLA 299 Gibberella zeae PH-1
EAA71175  239 MVTHDDYLGVTAQLYPSDDPYLETDTACAVKDDLVLDFKPakdd--------pkgaTLDVEYNINLA 297 Gibberella zeae PH-1

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