GPL13667[Accession] - GEO DataSets

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Select item 2002818111.

Combined inhibition of histone methyltransferases EZH2 and DOT1L is an effective therapy for neuroblastoma

(Submitter supplied) The child cancer, neuroblastoma (NB), is characterised by a low incidence of mutations and strong oncogenic embryonal driver signals. Many new targeted epigenetic modifier drugs have failed in human trials as monotherapy. We performed a high‐throughput, combination chromatin‐modifier drug screen against NB cells. We screened 13 drug candidates in 78 unique combinations. We found that the combination of two histone methyltransferase (HMT) inhibitors: GSK343, targeting EZH2, and SGC0946, targeting DOT1L, demonstrated the strongest synergy across 8 NB cell lines, with low normal fibroblast toxicity. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL13667
16 Samples

Download data: CEL, TXT

Series

Accession:: GSE281811

ID:: 200281811

PubMed

Select item 2002751262.

Subthreshold rejection activity in many kidney transplants currently classified as having no rejection.

(Submitter supplied) Most kidney transplant patients who undergo biopsies are classified as having no rejection based on consensus thresholds. However, we hypothesized that because these patients have normal adaptive immune systems, T cell-mediated rejection (TCMR) and antibody-mediated rejection (ABMR) may exist as subthreshold activity in some transplants currently classified as no rejection. Subthreshold molecular TCMR and/or ABMR activity molecular activity was detectable as elevated classifier scores in many biopsies classified as no rejection, with ABMR activity in many TCMR biopsies and TCMR activity in many ABMR biopsies. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL13667
5086 Samples

Download data: CEL, TXT

Series

Accession:: GSE275126

ID:: 200275126

PubMed Similar studies

Select item 2002300013.

Estrogen receptor β affects hypoxia response in colorectal cancer cells

(Submitter supplied) Our study identifies pathwyas related to tumour suppressor fuunction of estrogen receptor beta in colon cancer cells under hypoxic conditions.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL13667
24 Samples

Download data: CEL

Series

Accession:: GSE230001

ID:: 200230001

Analyze with GEO2R

Select item 2002501224.

The impact of endurance exercise on human skeletal muscle transcriptome

(Submitter supplied) The aim of this study was to elucidate the transcriptional signatures that distinguish the endurance-trained and the untrained muscle in healthy adult young males, both at baseline as well as in response to an acute bout of exercise.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL13667
48 Samples

Download data: CEL

Series

Accession:: GSE250122

ID:: 200250122

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2002287835.

Inter-patient heterogeneity in the hepatic ischemia-reperfusion injury transcriptome: implications for research and diagnostics

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL13667
152 Samples

Download data: CEL

Series

Accession:: GSE228783

ID:: 200228783

Select item 2002287826.

Inter-patient heterogeneity in the hepatic ischemia-reperfusion injury transcriptome: implications for research and diagnostics [MUG data]

(Submitter supplied) Background & Aims: Cellular responses induced by surgical procedure or ischemia-reperfusion injury (IRI) may severely alter transcriptome profiles. We have investigated this effect to obtain insight into molecular ischemia responses during surgical procedures and characterize pre-analytical effects impacting on molecular analyses. Methods: 143 non-malignant liver samples were obtained from 30 patients at different time points of ischemia during surgery from two individual cohorts, treated either with the Pringle maneuver or total vascular exclusion. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL13667
83 Samples

Download data: CEL, XLSX

Series

Accession:: GSE228782

ID:: 200228782

Select item 2002287817.

Inter-patient heterogeneity in the hepatic ischemia-reperfusion injury transcriptome: implications for research and diagnostics [EMC data]

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL13667
69 Samples

Download data: CEL, XLSX

Series

Accession:: GSE228781

ID:: 200228781

Select item 2002545258.

Quantification of totalRNA expression in oral squamous cell carcinoma(OSCC)

(Submitter supplied) Microarrays were used to compare the expression of oral squamous cell carcinoma in the high and low serum IL-6 groups. The results of the analysis may also be used to understand the disease, such as whether patients with high serum IL-6 levels have a poor prognosis or nutritional and metabolic activity status.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL13667
18 Samples

Download data: CEL

Series

Accession:: GSE254525

ID:: 200254525

Analyze with GEO2R

Select item 2002267819.

Stanniocalcin-1 mediates aortic valve calcification via promoting osteochondrogenic differentiation from valve interstitial cells

(Submitter supplied) Although calcific aortic valve stenosis (CAVS) is the most prevalent valvular heart disease, the molecular mechanisms underlying aortic valve calcification remain unknown. Here, we found a significant elevation in stanniocalcin-1 (STC1) expression in the valve interstitial cells (VICs) of calcific aortic valves by combined analysis of our comprehensive gene expression data and microarray datasets reported previously. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL13667
6 Samples

Download data: CEL

Series

Accession:: GSE226781

ID:: 200226781

Analyze with GEO2R

Select item 20024038910.

Functional analysis of miR-375 in oral squamous cell carcinoma cells

(Submitter supplied) We attempted to identify the miR-375-3p target genes using a microarray analysis to evaluate the function and transfection efficiency of miR-375-3p mimic.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL13667
8 Samples

Download data: CEL

Series

Accession:: GSE240389

ID:: 200240389

Analyze with GEO2R

Select item 20023061811.

Gene expression data from diabetic human adipose-derived stem cells (d-hASC) treated with 1uM oleacein

(Submitter supplied) Gene expression profiling reveals multiple biological functions of oleacein in diabetic model. We evaluated the effects of oleacein on diabetic human adipose-derived stem cells. We performed an untargeted whole-genome transcriptome analysis to explore functionality of oleacein in a diabetic adipose stem cell-based tool.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL13667
2 Samples

Download data: CEL, CHP, XLSX

Series

Accession:: GSE230618

ID:: 200230618

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20023583512.

Gene expression data from human neural stem cells (hNSCs) treated with 10 uM TCQA for 24 hours

(Submitter supplied) TCQA promoted differentiation of hNSCs at least toward the neuronal lineage and suggests the possibility of using TCQA to promote neurogenesis. When differentiation is induced by growth factor withdrawal, decreased expression of stemness gene and increased expression of NSC fate-promoting genes can be observed. Therefore, we evaluated the effect of TCQA on global gene expression in hNSCs during differentiation at 24h to elucidate the neurogenesis-promoting effects of TCQA.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL13667
4 Samples

Download data: CEL, CHP

Series

Accession:: GSE235835

ID:: 200235835

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20022701013.

MicroRNA-1289 functions as a novel tumor suppressor in oral squamous cell carcinoma

(Submitter supplied) Recently, a number of tumor suppressive microRNAs (TS-miRs) have been found in human ma-lignancies. In this study, we have attempted to identify a novel TS-miR in oral squamous cell carcinoma (OSCC) using function-based screening. First, we transfected human OSCC cells with 968 synthetic mimicking human mature miRs individually, and then the growth of these cells was evaluated. Five miRs significantly reduced the cell growth rate by less than 30%, and miR-1289 had the most potent growth inhibitory effect among these miRs. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL13667
6 Samples

Download data: CEL

Series

Accession:: GSE227010

ID:: 200227010

Analyze with GEO2R

Select item 20009758114.

Gene Expression Profile (GEP) of Cytokine-Induced Killer (CIK) cells

(Submitter supplied) Cytokine Induced Killer (CIK) cells are heterogeneous ex vivo expanded T lymphocytes with mixed T-NK phenotype and endowed with a wide MHC-unrestricted antitumor activity against both solid and hematologic malignancies. CIK cells can be easily ex vivo expanded up to clinical relevant rates from circulating peripheral blood mononuclear cells (PBMC), according to a standard protocol involving timed stimulation with IFN- γ (day 0), Ab-antiCD3 OKT3 (day 1) and IL-2 (from day 1 to the end). more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL13667
6 Samples

Download data: CEL

Series

Accession:: GSE97581

ID:: 200097581

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20021183915.

Expression data from SQ, TRI-SQ and Tetra-SQ-treated HFDPCs

(Submitter supplied) Gene expression profiling reveals a potential role of SQ, Tri-SQ, and Tetra-SQ in stimulating hair growth in dermal papilla cells. Squalene (SQ) was found to exhibit a strong antioxidant and anti-inflammatory activity; however, its biological effects is underestimated because of its insolubility. To overcome this problem, new amphiphilic SQ derivatives were synthesized and were used in this study to check their potential effect in vitro and in vivo on inducing hair growth while exhibiting an anti-aging property.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL13667
8 Samples

Download data: CEL, CHP, TXT

Series

Accession:: GSE211839

ID:: 200211839

Analyze with GEO2R

Select item 20004799416.

Tumor-infiltrating lymphocytes, prognosis and trastuzumab benefit in early-stage breast cancer patients from the FinHER trial

(Submitter supplied) The clinical relevance of tumor infiltrating lymphocytes (TILs) in breast cancer (BC) is not firmly established. We aimed to validate previous prognostic findings in triple negative breast cancer (TNBC) and investigate predictive associations with trastuzumab benefit in HER2 overexpressing disease (HER2+).

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL13667
337 Samples

Download data: CEL, TXT, ZIP

Series

Accession:: GSE47994

ID:: 200047994

Select item 20017457017.

Cabozantinib enhances anti-PD1 efficacy and elicits a neutrophil-based immune response in murine models: implications for human HCC

(Submitter supplied) Background & Aims: Immune checkpoint inhibitors combined with anti-angiogenic agents produces benefits in the treatment of advanced hepatocellular carcinoma (HCC). We investigated the efficacy and immunomodulatory activity of cabozantinib alone and combined with anti-PD1 in experimental models of HCC, and explored the potential target population that might benefit from this combination. Approach & Results: C57BL/6J mice bearing subcutaneous Hepa1-6 or Hep53.4 tumours received cabozantinib, anti-PD1, their combination or placebo. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL13667
114 Samples

Download data: CEL

Series

Accession:: GSE174570

ID:: 200174570

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20013790218.

Expression data from isolated endothelial cells from glioblastoma and normal brain cultured as monolayer on gelatin and on Matrigel

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL13667
15 Samples

Download data: CEL

Series

Accession:: GSE137902

ID:: 200137902

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20013790119.

Expression data from isolated endothelial cells from glioblastoma and normal brain cultured on Matrigel

(Submitter supplied) We compared gene expressions between CD31-positive cells from glioblastoma (TECs) and endothelial cells from normal brain (NECs) In this dataset, expression data obtained from Affymetrix Human Genome U219 Array (HG-U219) are presented.