GEO DataSets

(Submitter supplied) Using a systems biology approach, we discovered and dissected a three-way interaction between the immune system, the intestinal epithelium, and the microbiota. We found that mice lacking B lymphocytes, or lacking IgA, have low intestinal expression of lipid metabolism genes regulated by the transcription factor GATA4, and a consequent decrease in fat absorption in the intestine. The defect disappeared in germ free mice, suggesting that it is dependent on the microbiota; and sequencing analysis of the bacteria showed subtle differences between normal and B-cell deficient mice. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL14915

12 Samples

Download data: TXT

(Submitter supplied) Using a systems biology approach, we discovered and dissected a three-way interaction between the immune system, the intestinal epithelium, and the microbiota. We found that mice lacking B lymphocytes, or lacking IgA, have low intestinal expression of lipid metabolism genes regulated by the transcription factor GATA4, and a consequent decrease in fat absorption in the intestine. The defect disappeared in germ free mice, suggesting that it is dependent on the microbiota; and sequencing analysis of the bacteria showed subtle differences between normal and B-cell deficient mice. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL14915

20 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens; Mus musculus

Type:

Expression profiling by array

Platforms:

GPL6480 GPL14915 GPL6806

138 Samples

Download data: TXT

(Submitter supplied) NIAID Mmeb 44k (37.5k reporters) derived from Operon Mouse V4 oligo set. Length 60 bp probe sequences were generated by extracting base 10 through base 69 from the original 70 bp Operon probe. Agilent design number is 017138. For direct access, please contact [email protected]. Protocol: See manufacturer's web site at http://www.agilent.com/

Organism:

Mus musculus

3 Series

32 Samples

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