GEO DataSets

(Submitter supplied) T cell dysfunction is an important feature of many chronic viral infections. In particular, it was shown that PD-1 regulates T cell dysfunction during chronic LCMV infection in mice and PD-1 high cells exhibit an intense exhausted gene signature. These findings were extended to human chronic infections such as HIV, HCV and HBV. However, it is not known if PD-1 high cells of healthy humans have the traits of exhausted cells. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4226

Platform:

GPL570

16 Samples

Download data: CEL, CHP

Analysis of PD-1hi, PD-1lo, and naive CD8+CD3+ T cells FACS-sorted from peripheral blood of healthy adults. PD-1, a member of the CD28 family of immune modulators, is highly expressed on chronic virus-specific CD8 T cells. Results provide insight into PD-1-expressing CD8 T cells in healthy adults.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 3 cell type sets

Platform:

GPL570

Series:

GSE26495

16 Samples

Download data: CEL, CHP

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 06, 2012: annotation table updated with netaffx build 32 June 23, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site Complete coverage of the Human Genome U133 Set plus 6,500 additional genes for analysis of over 47,000 transcripts All probe sets represented on the GeneChip Human Genome U133 Set are identically replicated on the GeneChip Human Genome U133 Plus 2.0 Array. more...

Organism:

Homo sapiens

602 DataSets

5671 Series

61 Related Platforms

175585 Samples

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