GEO DataSets

Analysis of various skeletal muscles of trangenics expressing the human Met9Arg alpha-tropomyosin slow mutant gene, a model of nemaline myopathy (NM). NM, a non-dystrophic congenital myopathy, is a variably severe neuromuscular disorder. Results provide insight into the pathogenesis of NM.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 age, 2 disease state, 5 tissue sets

Platform:

GPL81

Series:

GSE3384

36 Samples

Download data: CEL, EXP

Analysis of livers of animals following bile duct ligation to induce extrahepatic cholestasis. Biliary tract obstruction is a common mechanism of hepatic injury. Results provide insight into molecular mechanisms that influence injury and repair in cholestatic liver disease.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 protocol sets

Platform:

GPL81

Series:

GSE29776

6 Samples

Download data: CEL

Analysis of cortex from SHARP1/2 double null mutants at ZT4 (wake phase) and ZT16 (sleep phase). bHLH transcription factors SHARP1 (DEC2, BHLHE41) and SHARP2 (DEC1, BHLHE40) are circadian modulators. Results provide insight into the molecular contributions of SHARP1/SHARP2 to the sleep-wake cycle.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation, 2 time sets

Platform:

GPL81

Series:

GSE59941

8 Samples

Download data: CEL

Analysis of LCM samples of the subgranular zone (SGZ) of the hippocampal dentate gyrus isolated from adults subjected to running for up to 30 days. The SGZ is a major site of neurogenesis in adult brain. Running enhances SGZ proliferation. Results provide insight into the SGZ molecular environment.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 cell type, 9 individual, 2 protocol, 3 time sets

Platform:

GPL81

Series:

GSE39697

18 Samples

Download data: CEL

Analysis of FACS-sorted, GFP-positive endothelial cells from retinas of postnatal day 8 (P8) homozygous Tie2-GFP transgenics. Deregulated retinal angiogenesis causes vision loss in many ocular diseases. Results provide insight into the molecular mechanisms underlying intraretinal angiogenesis.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 cell type sets

Platform:

GPL81

Series:

GSE27238

6 Samples

Download data: CEL

Analysis of cultured cortical neurons treated with 1uM lactacystin for up to 48 hr. Lactacystin induces neuronal apoptosis. Results provide insight into molecular mechanisms underlying proteasomal inhibition-induced neuronal death.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 agent, 2 time sets

Platform:

GPL81

Series:

GSE22465

6 Samples

Download data: CEL

Analysis of pancreatic lymph nodes of Early Insulin AutoAntibodies (E-IAA) positive 5 wk-old Non Obese Diabetic (NOD) mice. E-IAA mark the first measurable phenotypic checkpoint in T1D pathogenesis. Results provide insight into molecular mechanisms underlying initiation of T1D.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 genotype/variation sets

Platform:

GPL81

Series:

GSE15582

9 Samples

Download data: CEL

Analysis of therapeutic-GM4 and nontherapeutic-GM bone marrow-derived NOD dendritic cells (DC) up to 20 hrs after activation with LPS + IFN-gamma. The GM4 DC population is able to prevent diabetes in NOD mice. Results provide insight into the molecular basis of the therapeutic effect of GM4 DC.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 agent, 2 cell type, 3 time sets

Platform:

GPL81

Series:

GSE15320

15 Samples

Download data: CEL, CHP

Analysis of adrenal glands from 12-week old, chromogranin A knockouts (Chga KO). The Chga KO displays severe hypertension coupled with reduction in size, number, and density of regulated secretory granules. Results provide insight into the molecular basis of this monogenic hypertension model.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation sets

Platform:

GPL81

Series:

GSE18332

6 Samples

Download data: CEL, CHP

Analysis of adrenal glands from genetically/hereditary hypertensive (BPH/2) and genetically/hereditary low-blood pressure (BPL/1) 12-week old adults. Results provide insight into molecular mechanisms underlying the pathogenesis of genetic hypertension.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 strain sets

Platform:

GPL81

Series:

GSE19342

6 Samples

Download data: CEL, CHP

Analysis of brains of nicotine-induced seizure-sensitive (alpha7 +/T) and -resistant (beta4 -/-) nicotinic acetylcholine receptor (nAChR) mutants following nicotine treatment. Results provide insight into the molecular mechanisms underlying seizures.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 agent, 3 genotype/variation sets

Platform:

GPL81

Series:

GSE6614

28 Samples

Download data: CEL, CHP

Analysis of livers from hormone-sensitive lipase (HSL) null mutants fed a high fat diet. Decreased hepatic insulin sensitivity and elevation of plasma cholesterol are observed in this HSL-null animal model. Results provide insight into the mechanisms underlying these features.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation, 2 protocol sets

Platform:

GPL81

Series:

GSE10067

4 Samples

Download data: CEL, EXP

Analysis of ileum from human enterocyte-associated E-cadherin receptor-expressing, germ-free transgenic mice (Fabpi-hEcad) colonized with wildtype L. monocytogenes or mutant strains with inlA, inlB, hly deletions. Results provide insight into host response to invasive foodborne enteropathogens.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 9 infection sets

Platform:

GPL81

Series:

GSE7013

20 Samples

Download data: CEL, EXP

Analysis of retroperitoneal adipose tissue samples from gonadectomized males and females following treatment with dihydrotestosterone (DHT) for up to 24 hours. Results provide insight into the role of DHT in the adipogenesis that occurs in retroperitoneal adipose tissues.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 agent, 2 gender, 7 time sets

Platform:

GPL81

Series:

GSE9631

16 Samples

Download data: CEL

Analysis of cultured embryonic stem (ES) cells overexpressing the transcription factor STAT3. STAT3 is a downstream target of the LIF signaling cascade. LIF activation maintains ES cells in a pluripotent state. Results provide insight into the role of STAT3 in maintenance of ES cell pluripotency.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 protocol sets

Platform:

GPL81

Series:

GSE11398

6 Samples

Download data: CEL, CHP

Analysis of splenic CD11b+ cells from animals infected with wildtype Yersinia enterocolitica (Ye) or a YopH-deficient Ye mutant. YopH is a virulence factor that inhibits phagocytosis of Ye and promotes virulence of Ye. Results provide insight into the molecular basis of YopH-mediated immune evasion.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 dose, 3 infection sets

Platform:

GPL81

Series:

GSE11189

5 Samples

Download data: CEL, CHP

Analysis of visual cortices before the critical period for ocular dominance plasticity opens [postnatal day 14 (P14)], at the peak sensitivity of the critical period (P28), and after the critical period (P60). Results provide insight into the molecular mechanisms associated with the critical period.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 age sets

Platform:

GPL81

Series:

GSE11764

10 Samples

Download data: CEL, CHP

Analysis of kidneys from C57Bl transgenics expressing human fibroblast growth factor-23 (FGF23). FGF23 is a circulating protein that causes decreased renal inorganic phosphate (Pi) reabsorption. Results provide insight into molecular mechanisms underlying the regulation of Pi homeostasis by FGF23.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 strain sets

Platform:

GPL81

Series:

GSE6979

10 Samples

Download data: CEL, EXP

Analysis of STAT5A and STAT5B depleted proB Ba/F3-beta cells stimulated with IL-3 for 0.5 or 2 hours. STAT5A and STAT5B are members of the family of signal transducers and activators of transcription. Results identify IL-3 inducible STAT5 target genes.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 agent, 2 protocol, 3 time sets

Platform:

GPL81

Series:

GSE10389

5 Samples

Download data: CEL, CHP

Analysis of primary culture tracheal epithelial cells following infection with Sendai virus (SeV), a common paramyxovirus.Respiratory paramyxoviral infections are a leading cause of serious respiratory disease. Results provide insight into the role of epithelial cells in antiviral defense.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 infection sets

Platform:

GPL81

Series:

GSE10211

10 Samples

Download data: CEL