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| Status |
Public on Oct 02, 2009 |
| Title |
Over expression of mRNA for multiple genes including insulin in the PLN of NOD is associated with Islet Autoimmunity |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
The aim of this study is to identify genes implicated in the early steps of the autoimmune process, prior to inflammation in type 1 diabetes. Early Insulin AutoAntibodies (E-IAA) have been used as subphenotypic marker to select individual animals as type 1 diabetes prone and to compare gene expression patterns with insulin autoantibody negative NOD.
Variation of gene expression patterns in the pancreatic lymph nodes (PLN) issued from E-IAA positive and negative mice have been analyzed by DNA microarrays
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| Overall design |
PLN were used from 5 weeks old NOD mice positive for Insulin Autoantibodies and compared with animals negative for Insulin AutoAntibodies
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| Contributor(s) |
Regnault B, Osorio y Fortea J, Miao D, Eisenbarth G, Melanitou E |
| Citation(s) |
19799787, 26629415 |
| |
| Submission date |
Apr 07, 2009 |
| Last update date |
Jul 31, 2019 |
| Contact name |
Evie Melanitou |
| E-mail(s) |
[email protected]
|
| Phone |
+33 1 40 61 3299
|
| Fax |
+33 1 45 68 8332
|
| Organization name |
Institut Pasteur
|
| Department |
Parasitology & Mycology
|
| Lab |
Immunophysiology and intracellular parasitism
|
| Street address |
25 rue du Dr Roux
|
| City |
Paris |
| ZIP/Postal code |
75015 |
| Country |
France |
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| Platforms (1) |
| GPL81 |
[MG_U74Av2] Affymetrix Murine Genome U74A Version 2 Array |
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| Samples (9)
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| Relations |
| BioProject |
PRJNA115587 |
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