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Links from GEO DataSets

Items: 20

1.
Full record GDS1261

GH/IGF-1 signaling disruption and caloric restriction additive effect

Analysis of livers from growth hormone/insulin-like growth factor-1 signaling defective Ames dwarfs (DF) subjected to caloric restriction (CR). DF and CR in combination additively extend life span. Results provide insight into the mechanisms underlying this additive effect.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 genotype/variation, 2 protocol sets
Platform:
GPL81
Series:
GSE1093
31 Samples
Download data
DataSet
Accession:
GDS1261
ID:
1261
2.

caloric restriction

(Submitter supplied) Mice were killed between 24 to 26 months of age, tissues removed, rapidly frozen on dry ice, and stored in liquid nitrogen. Total liver RNA was isolated from frozen tissue as described (T. Tsuchiya, J.M. Dhahbi, X. Cui, P.L. Mote, A. Bartke, S.R. Spindler, Physiological Genomics, Submitted). mRNA levels were measured using the Affymetrix mouse U74Av2 array according to standard protocols. After hybridization, arrays were scanned using a Hewlett-Packard GeneArray Scanner. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS1261
Platform:
GPL81
31 Samples
Download data
Series
Accession:
GSE1093
ID:
200001093
3.

Normal Calorie Restricted

(Submitter supplied) Normal female Ames mouse (+/+ or +/df) with ad libitum access to water and fed 30% less of the standard pelleted diet with respect to the amount consumed by normal female ad libitum fed +/+ and +/df mice (LabDiet, PMI Feeds, Inc., St Louis, MO) caged with microisolator filter tops. Mice were killed between 24 to 26 months of age, tissues removed, rapidly frozen on dry ice, and stored in liquid nitrogen. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL81
8 Samples
Download data
Series
Accession:
GSE1089
ID:
200001089
4.

Normal Ad Libitum

(Submitter supplied) Female Ames dwarf mouse (+/+ or +/df) with ad libitum access to water and standard pelleted food (LabDiet, PMI Feeds, Inc., St Louis, MO) caged with microisolator filter tops. Mice were killed between 24 to 26 months of age, tissues removed, rapidly frozen on dry ice, and stored in liquid nitrogen. Total liver RNA was isolated from frozen tissue as described (T. Tsuchiya, J.M. Dhahbi, X. Cui, P.L. Mote, A. Bartke, S.R. Spindler, Physiological Genomics, Submitted). mRNA levels were measured using the Affymetrix mouse U74Av2 array according to standard protocols. After hybridization, arrays were scanned using a Hewlett-Packard GeneArray Scanner. Image analysis was performed as described (Cao SX, Dhahbi JM, Mote PL, and Spindler SR. Genomic profiling of short- and long-term caloric restriction effects in the liver of aging mice. Proc Natl Acad Sci U S A 98: 10630-10635, 2001). A more detailed description of the methods can be found in (T. Tsuchiya, J.M. Dhahbi, X. Cui, P.L. Mote, A. Bartke, S.R. Spindler, Physiological Genomics, Submitted). Keywords = Ames dwarf Keywords = mouse Keywords = Affymetrix Keywords = caloric restriction Keywords: parallel sample
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL81
7 Samples
Download data
Series
Accession:
GSE1088
ID:
200001088
5.

Dwarf Calorie Restricted

(Submitter supplied) Female Ames dwarf mouse (df/df) with ad libitum access to water and fed 30% less of the standard pelleted diet with respect to the amount consumed by female ad libitum fed df/df mice (LabDiet, PMI Feeds, Inc., St Louis, MO) caged with microisolator filter tops. Mice were killed between 24 to 26 months of age, tissues removed, rapidly frozen on dry ice, and stored in liquid nitrogen. Total liver RNA was isolated from frozen tissue as described (T. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL81
8 Samples
Download data
Series
Accession:
GSE1087
ID:
200001087
6.

Dwarf Ad libitum

(Submitter supplied) Female Ames dwarf mouse (df/df) with ad libitum access to water and standard pelleted food (LabDiet, PMI Feeds, Inc., St Louis, MO) caged with microisolator filter tops. Mice were killed between 24 to 26 months of age, tissues removed, rapidly frozen on dry ice, and stored in liquid nitrogen. Total liver RNA was isolated from frozen tissue as described (T. Tsuchiya, J.M. Dhahbi, X. Cui, P.L. Mote, A. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL81
8 Samples
Download data
Series
Accession:
GSE1086
ID:
200001086
7.

Plane of nutrition prepartum and bovine hepatic gene expression profiles

(Submitter supplied) Cows were selected from two groups of 12 cows enrolled in a large experiment to assess the effects of ad libitum or restricted intake of moderate-energy diets during the entire dry period on pre-partum metabolism and post-partum metabolism and performance. A corn silage-based diet (26% of diet dry matter) providing 1.59 Mcal/kg during the far-off dry period (first 5 wk of an 8-wk dry period) or providing 1.61 Mcal/kg during the close-up dry period (last 3 wk of the dry period) was fed for ad libitum or restricted intake. more...
Organism:
Bos taurus
Type:
Expression profiling by array
Platform:
GPL2864
106 Samples
Download data
Series
Accession:
GSE3331
ID:
200003331
8.

microarray profiling of potential calorie restriction mimetics

(Submitter supplied) Mice and diets. One-month-old male mice of the long-lived B6C3F1 strain were purchased from Harlan (Indianapolis, IN) and maintained as described after weaning (15). Mice were housed in groups of 4 per cage and fed a non-purified diet, PMI Nutrition International Product #5001 (Purina Mills, Richmond, IN). At 5 months of age, the mice were individually housed, and randomly assigned to one of two groups, control (CON) or long-term CR (LTCR). more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS1808
Platform:
GPL81
32 Samples
Download data
Series
Accession:
GSE2431
ID:
200002431
9.
Full record GDS1808

Candidate calorie restriction mimetic drugs effect on the liver

Analysis of livers of long-lived B6C3F1 animals fed a diet containing metformin, glipizide, rosiglitazone, or soy isoflavone extract. Results compared to hepatic gene expression profile produced by long-term caloric restriction. Caloric restriction extends the life span of laboratory animals.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 6 agent, 3 protocol sets
Platform:
GPL81
Series:
GSE2431
32 Samples
Download data
DataSet
Accession:
GDS1808
ID:
1808
10.

Short-term growth hormone treatment on the liver and muscle transcriptome in rainbow trout (Oncorhynchus mykiss)

(Submitter supplied) Although studies have established that exogenous growth hormone (GH) treatment stimulates growth in fish, its effects on target tissue gene expression are not well characterized. We assessed the effects Posilac® (Monsanto Co., St. Louis, MO), a recombinant bovine somatotropin, on tissue transcript levels. Transcript abundance was measure in liver and muscle using the GRASP 16 K cDNA microarray. A selection of the genes identified as altered with the microarray, and also transcripts for insulin-like growth factors, growth hormone receptors (GHR) and myostatins were measured by realtime PCR in the liver, muscle, brain, kidney, intestine, stomach, gill and heart. more...
Organism:
Oncorhynchus mykiss; Salmo salar
Type:
Expression profiling by array
Platform:
GPL3976
16 Samples
Download data: TXT
Series
Accession:
GSE8285
ID:
200008285
11.

Comparison of WT Vs NaS1-/- livers

(Submitter supplied) Pairwise comparison of gene expression in pools (n=14) of wildtype 4 week old male Vs NaS1-/- knockout mice. Keywords: normal Vs mutant
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1867
4 Samples
Download data
Series
Accession:
GSE3745
ID:
200003745
12.

Mild food restriction and gene expression profile (liver)

(Submitter supplied) The aim of this study is to obtain the gene expression profiles of the liver of young growing rats after mild restriction of food intake for one week or one month.
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL341
20 Samples
Download data: CEL
Series
Accession:
GSE18297
ID:
200018297
13.

Calorie Restriction Feminizes Liver Gene Expression and Alters Key Regulators of Conserved Aging Regulatory Pathways

(Submitter supplied) Background: Calorie restriction (CR) is the only intervention known to extend lifespan in a wide range of organisms, including mammals. However, the mechanisms by which it regulates mammalian aging remain largely unknown and the involvement of the TOR and Sirtuin pathways (which regulate aging in lower organisms) remain controversial. Femaleness is a second phenotype generally associated with longevity but the relationship between sex-biased and CR-induced gene expression remains undetermined. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6761
23 Samples
Download data: GPR
Series
Accession:
GSE11244
ID:
200011244
14.

Gene expression profile from short-term caloric restriction in mouse adipose tissue

(Submitter supplied) To provide a robust understanding of a transcriptomic change by short-term CR at body fat of mice, we applied three serial strengths of CR to mice including 15%, 30%, and 45% reduction of carbon source. Using Affymetrix mouse 1.0 ST array platform, we obtained and analyzed the transcriptome data for significantly changed genes in expression. Here, we identified 446 genes and categorized the genes based on their biological roles. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
12 Samples
Download data: CEL
Series
Accession:
GSE60596
ID:
200060596
15.

Circadian alignment of early onset caloric restriction promotes longevity in male C57BL/6J mice

(Submitter supplied) Caloric restriction (CR) prolongs lifespan, yet the mechanisms by which it does so remain poorly understood. Under CR, mice self-impose chronic cycles of 2-hour-feeding and 22-hour-fasting, raising the question whether calories, fasting, or time of day are causal. We show that 30%-CR is sufficient to extend lifespan 10%; however, a daily fasting interval and circadian-alignment of feeding act together to extend lifespan 35% in male C57BL/6J mice. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19057
288 Samples
Download data: XLSX
Series
Accession:
GSE190939
ID:
200190939
16.

Gene expression in liver tissue from Ghrh-KO and normal (wild-type) mice

(Submitter supplied) The hypothalamus has recently emerged as a key regulator of metabolism and aging in mammals. We have examined the impact of targeted disruption of hypothalamic hypophysiotropic peptide: Growth Hormone-releasing Hormone (GHRH) in mice on longevity, and the putative mechanisms of delayed aging. GHRH knockout (KO) mice are remarkably long-lived and in comparison to genetically normal (wild type) animals exhibiting major shifts in the expression of genes related to xenobiotic detoxification, stress resistance, and insulin signaling. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
6 Samples
Download data: CEL
Series
Accession:
GSE51108
ID:
200051108
17.

Ovarian transcriptome associated with reproductive senescence in the long-living Ames dwarf mice

(Submitter supplied) The aim of the current work was to evaluate the ovarian transcriptome in Ames dwarf (df/df) mice. df/df mice have a delayed ovarian aging compared to normal (N) mice. Although a high number of genes were differentially expressed during aging of N mice, only a small fraction of these changed with aging in df/df mice. These alterations involved more than 500 categorized biological processes. The majority of these biological processes, including inflammatory/immune responses, were up-regulated with aging in N mice, while old df/df mice were characterized by down-regulation of these same processes in comparison to age matched N mice. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13112
20 Samples
Download data: GTF, TXT
Series
Accession:
GSE84078
ID:
200084078
18.

Mouse feeding experiment

(Submitter supplied) Mice used in this study were 129/sv males, 8-15 weeks of age, which were housed individually and received water ad libitum. Normal fed animals were fed before and during the 48h experiment with standard food ad libitum. Sugar fed animals were fed before the experiment with standard food ad libitum and during the 48h experiment with 50% (w/v) sugar solution (40% glucose, 10% sucrose). Mice were killed by CO2 asphyxiation. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL765
60 Samples
Download data
Series
Accession:
GSE858
ID:
200000858
19.

liver, 24h starved

(Submitter supplied) Mice used in this study were 129/sv males, 8-15 weeks of age, which were housed individually and received water ad libitum. Normal fed animals were fed before and during the 48h experiment with standard food ad libitum. Starved animals were fed before the experiment with standard food ad libitum and were starved during the 24h experiment. Mice were killed by CO2 asphyxiation. The livers were snap-frozen in liquid nitrogen and stored at -80 degrees C. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL765
24 Samples
Download data
Series
Accession:
GSE853
ID:
200000853
20.

liver, 48h starved

(Submitter supplied) Mice used in this study were 129/sv males, 8-15 weeks of age, which were housed individually and received water ad libitum. Normal fed animals were fed before and during the 48h experiment with standard food ad libitum. Starved animals were fed before the experiment with standard food ad libitum and were starved during the 48h experiment. Mice were killed by CO2 asphyxiation. The livers were snap-frozen in liquid nitrogen and stored at -80 degrees C. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL765
24 Samples
Download data
Series
Accession:
GSE852
ID:
200000852
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