GEO DataSets

(Submitter supplied) Comparative expression analysis of RNA isolated from microvesicles from serum from glioblastoma multiforme (GBM) patients and normal healthy individuals.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL8755

16 Samples

Download data: TXT

(Submitter supplied) We used microarrays to perform systematic profiling of human microRNAs in serum from glioblastoma multiforme (GBM) patients to find potential biomarkers. By comparing the serum microRNA profiles of the GBM patients and healthy volunteers, potential biomarkers for GBM were investigated. Using a custom microarray platforms containing 1843 species of miRNAs, we previously identified 19 serum miRNAs with differential expression in GBM patients.

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL22948

30 Samples

Download data: GPR

(Submitter supplied) Neurosurgical aspirate fluids captured during tumour resections are a rich source of glioma extracellular vesicles (EVs) isolated directly from tumour microenvironments. The sncRNA contents of EVs derived from 17 neurosurgical aspirates were profiled using the Illumina® NextSeqTM 500 NGS System.

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by high throughput sequencing

Platform:

GPL18573

17 Samples

Download data: XLSX

(Submitter supplied) Background: Safe and sensitive methods for glioblastoma diagnosis and disease monitoring are urgently needed. Exosomes are nano-sized extracellular vesicles that contain molecules characteristic of their cell-of-origin, including microRNA. Exosomes released by glioblastoma tumors cross the blood-brain-barrier ino the peripheral circulation. Methods: Serum exosomal-microRNA isolated from IDH-wildtype glioblastoma (n=12) and IDH-mutant glioma grades II-III (n=10) were analyzed using small-RNA next generation sequencing and compared to age- and gender-matched healthy controls. more...

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by high throughput sequencing

Platform:

GPL11154

38 Samples

Download data: TXT

(Submitter supplied) Glioblastoma multiforme (GBM) is the most common and aggressive primary human brain tumor. Although comprehensive therapies combining radiotherapy and chemotherapy after surgery can prolong survival, the prognosis is still poor with a median survival of only 14.6 months. Chemoresistance is one of the major causes of relapse as well as poor survival in glioma patients. Therefore, novel strategies to overcome chemoresistance are desperately needed for improved treatment of human GBM. more...

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL27713

6 Samples

Download data: TXT

(Submitter supplied) Congenital glioblastoma multiforme (cGBM) historically has been considered an aggressive tumor of infancy requiring extensive chemotherapy to achieve cure. We report on 4 patients at our institution with cGBMs who were treated with surgery and chemotherapy (carboplatin and etoposide every 21 days for 2-6 cycles). Four of four patients are progression free at a median time of 27.5 months (22-103 months). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

21 Samples

Download data: CEL

(Submitter supplied) Gene expression profiling of circulating plasma RNA is a valuable tool to detect cancer and a potential clinical instrument to study tumor progression and therapy responsiveness. In this study, differential gene expression analysis was used to identify genes specifically increased in cancer patients. Keywords: Disease state analysis

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS2918

Platform:

GPL3014

20 Samples

Download data: GPR

Analysis of blood plasma from patients with colorectal cancer. Results used to identify gene markers for colorectal cancer.

Organism:

Homo sapiens

Type:

Expression profiling by array, log ratio, 2 disease state sets

Platform:

GPL3014

Series:

GSE4988

20 Samples

Download data: GPR

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

synthetic construct; Homo sapiens

Type:

Expression profiling by array; Non-coding RNA profiling by array

Platforms:

GPL17692 GPL21572

50 Samples

Download data: CEL, CHP

(Submitter supplied) Although glioblastoma multiforme is a common brain tumor, there is a need to elucidate underlying mechanisms behind its initiation and progression and identifying key molecular pathways for improving treatment. Here, we used combined miRNA-mRNA transcriptome analysis to discover novel genes and networks in GBM

Organism:

Homo sapiens; synthetic construct

Type:

Non-coding RNA profiling by array

Platform:

GPL21572

25 Samples

Download data: CEL, CHP

(Submitter supplied) Although glioblastoma multiforme is a common brain tumor, there is a need to elucidate underlying mechanisms behind its initiation and progression and identifying key molecular pathways for improving treatment. Here, we used combined miRNA-mRNA transcriptome analysis to discover novel genes and networks in GBM

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL17692

25 Samples

Download data: CEL, CHP

(Submitter supplied) Background: Gliomas are the most common type of primary brain tumours, and in this group glioblastomas (GBMs) are the higher-grade gliomas with fast progression and unfortunate prognosis. Two major aspects of glioma biology that contributes to its awful prognosis are the formation of new blood vessels through the process of angiogenesis and the invasion of glioma cells. Despite of advances, two-year survival for GBM patients with optimal therapy is less than 30%. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

16 Samples

Download data: CEL, CHP, TXT

(Submitter supplied) Overexpression of miR-31 inhibits the migration and invasion ability of glioma cell. We sought to obtain the genes regulated by mir-31 in glioma cell line.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

2 Samples

Download data: CEL

(Submitter supplied) Glioblastoma tumour cells release microvesicles (exosomes) containing mRNA, miRNA and angiogenic proteins. These microvesicles are taken up by normal host cells, such as brain microvascular endothelial cells. By incorporating an mRNA for a reporter protein into these microvesicles, we demonstrate that messages delivered by microvesicles are translated by recipient cells. These microvesicles are also enriched in angiogenic proteins and stimulate tubule formation by endothelial cells. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL4133

2 Samples

Download data: TXT

(Submitter supplied) Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract affecting over 3 million adults in the United States. Despite being widespread, reliable early diagnostic tests are not available. In order to remedy this, we examined exosomal small RNA (smRNA), specifically targeting microRNA (miRNA) and piRNA from the stool samples of IBD model mice, interleukin 10 knockout mice (IL-10 KO), as a potential diagnostic marker. more...

Organism:

Mus musculus

Type:

Non-coding RNA profiling by high throughput sequencing

Platform:

GPL24247

17 Samples

Download data: CSV