Similar studies for GEO DataSets (Select 200024446) - GEO DataSets

(Submitter supplied) GBM is a heterogenous tumor. Based on membrane protein expression, the GBM single cell dissociates were seperated into different subfractions by FACS assay. The genomic aberration among each populations were compared by analysis of CGH data.

Organism:: Homo sapiens

Type:: Genome variation profiling by array

Platform:: GPL5477
14 Samples

Download data: TXT

Series

Accession:: GSE24452

ID:: 200024452

Select item 2000242445.

Gene expression profiling of four subpopulations in GBM

(Submitter supplied) GBM is a heterogenous brain tumor with hyperproliferation of endothelial cells. In order to understand the cellular mechanism of vasculogenesis in GBM, four fractions of cells are seperated. Microarray assays was performed to examine the potential lineage relationship and the signal pathways involved in determining the cell identity and function.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
8 Samples

Download data: CEL, CHP

Series

Accession:: GSE24244

ID:: 200024244

Select item 2000180156.

Molecular analysis of ex-vivo CD133+ GBM cells revealed a common invasive and angiogenic profile but different proliferative signatures among high grade gliomas.

(Submitter supplied) Background: Gliomas are the most common type of primary brain tumours, and in this group glioblastomas (GBMs) are the higher-grade gliomas with fast progression and unfortunate prognosis. Two major aspects of glioma biology that contributes to its awful prognosis are the formation of new blood vessels through the process of angiogenesis and the invasion of glioma cells. Despite of advances, two-year survival for GBM patients with optimal therapy is less than 30%. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
16 Samples

Download data: CEL, CHP, TXT

Series

Accession:: GSE18015

ID:: 200018015

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000439317.

Prominin 1/CD133 Endothelium Sustains Growth of Proneural Glioma

(Submitter supplied) As many other tumors, a subset of gliobastoma is thought to be maintained by a restricted population of cancer cells, stem-like cells that express CD133 transmembrane protein. Expression levels of CD133 gene has been linked to a poor prognostic molecular subgroup and is not overexpressed by the PDGF-driven proneural group. Thus, the significance of CD133+ cells for gliomagenesis of the proneural group is undetermined. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
2 Samples

Download data: CEL, CHP

Series

Accession:: GSE43931

ID:: 200043931

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000445618.

Effect of Notch1 pathway activation on high-grade glioma cells

(Submitter supplied) In this study, we explored the transcriptomic consequences of strong activation of the Notch pathway in embryonic human neural stem cells and in gliomas. For this we used a forced expression of the Notch intracellular domain (NICD). Glioblastoma multiforms (GBMs) are highly vascularized brain tumors containing a subpopulation of multipotent cancer stem cells. These cells closely interact with endothelial cells in neurovascular niches. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS5671
Platform:: GPL11532
8 Samples

Download data: CEL, CHP

Series

Accession:: GSE44561

ID:: 200044561

Select item 56719.

Notch1 stimulation effect on glioblastoma stem cell cultures

Analysis of Gb4 and Gb7 glioma cancer stem cells following forced expression of the Notch1 intracellular domain (NICD) to activate the Notch1 signaling pathway. Results provide insight into a role for the Notch1 pathway in glioblastoma stem cell plasticity and angiogenic properties.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 4 cell type, 2 genotype/variation sets

Platform:: GPL11532
Series:: GSE44561
8 Samples

Download data: CEL, CHP

DataSet

Accession:: GDS5671

ID:: 5671

Select item 20000718110.

CD133+ and CD133- CSC lines in primary human GBM

(Submitter supplied) We cultured tumor cells from 22 GBM under medium conditions favoring the growth of neural stem cells. 11 out of 15 primary GBM contained a significant CD133+ subpopulation that comprised cells showing all hallmarks of neural stem cells. Cell lines derived from these CD133+ GBM showed a neurosphere-like, non-adherent growth pattern. In contrast, 4 out of 15 cell lines derived from primary GBM grew adherent in vitro and were driven by CD133- tumor cells that fulfilled stem cell criteria. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS2728
Platform:: GPL570
6 Samples

Download data: CEL, CHP

Series

Accession:: GSE7181

ID:: 200007181

Select item 272811.

CD133+ and CD133- glioblastoma-derived cancer stem cell lines

Comparison of CD133+ and CD133- glioblastoma-derived cancer stem cells (CSC). Both CSC subpopulations were derived from primary glioblastomas. Results provide insight into the role of CD133+ and CD133- CSCs in the pathogenesis of glioblastoma.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 2 cell line sets

Platform:: GPL570
Series:: GSE7181
6 Samples

Download data: CEL, CHP

DataSet

Accession:: GDS2728

ID:: 2728

Select item 20001021012.

Gene expression analysis of embryonic stem cells expressing VE-cadherin (CD144) during endothelial differentiation

(Submitter supplied) Endothelial differentiation occurs during normal vascular development in the developing embryo. Mouse embryonic stem (ES) cells were used to further define the molecular mechanisms of endothelial differentiation. By flow cytometry a population of VEGF-R2 positive cells was identified as early as 2.5 days after differentiation of ES cells, and a subset of VEGF-R2 + cells, that were CD41+ positive at 3.5 days. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
16 Samples

Download data: CEL

Series

Accession:: GSE10210

ID:: 200010210

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20004067613.

CD133/CD140a-Based Isolation of Distinct Human Multipotent Neural Progenitor Cells and Oligodendrocyte Progenitor Cells

(Submitter supplied) The mechanisms underlying the specification of oligodendrocyte fate from multipotent neural progenitor cells (NPCs) in developing human brain are unknown. In this study, we sought to identify antigens sufficient to distinguish NPCs free from oligodendrocyte progenitor cells (OPCs). We investigated the potential overlap of NPC and OPC antigens using multicolor fluorescence-activated cell sorting (FACS) for CD133/PROM1, A2B5, and CD140a/PDGFaR antigens. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
12 Samples

Download data: TXT

Series

Accession:: GSE40676

ID:: 200040676

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20024313214.

METTL7B is an essential epigenetic regulator of lineage specification in glioblastoma

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Methylation profiling by genome tiling array

Platforms:: GPL24676 GPL21145
73 Samples

Download data: BEDGRAPH, BW, IDAT, MTX, TSV

Series

Accession:: GSE243132

ID:: 200243132

PubMed Full text in PMC Similar studies

Select item 20024313015.

METTL7B is an essential epigenetic regulator of lineage specification in glioblastoma [DNAme]

(Submitter supplied) Glioblastomas are the most common malignant brain tumours in adults; they are highly aggressive, heterogeneous and plastic. We have identified METTL7B as an essential regulator of lineage specification in glioblastoma, with impact on both tumour size and invasiveness in in vivo models. Single cell transcriptomic analysis of these tumours and of cerebral organoids derived from expanded potential stem cells overexpressing METTL7B identified a regulatory role for the gene in the neural stem cells to astrocyte differentiation trajectory. more...

Organism:: Homo sapiens

Type:: Methylation profiling by genome tiling array

Platform:: GPL21145
16 Samples

Download data: IDAT, TXT

Series

Accession:: GSE243130

ID:: 200243130

PubMed Full text in PMC Similar studies

Select item 20024296616.

METTL7B is an essential epigenetic regulator of lineage specification in glioblastoma [scRNAseq]

(Submitter supplied) Glioblastomas are the most common malignant brain tumours in adults; they are highly aggressive, heterogeneous and plastic. We have identified METTL7B as an essential regulator of lineage specification in glioblastoma, with impact on both tumour size and invasiveness in in vivo models. Single cell transcriptomic analysis of these tumours and of cerebral organoids derived from expanded potential stem cells overexpressing METTL7B identified a regulatory role for the gene in the neural stem cells to astrocyte differentiation trajectory. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
9 Samples

Download data: MTX, TSV

Series

Accession:: GSE242966

ID:: 200242966

PubMed Full text in PMC Similar studies

Select item 20024232817.

METTL7B is an essential epigenetic regulator of lineage specification in glioblastoma [RNAseq]

(Submitter supplied) Glioblastomas are the most common malignant brain tumours in adults; they are highly aggressive, heterogeneous and plastic. We have identified METTL7B as an essential regulator of lineage specification in glioblastoma, with impact on both tumour size and invasiveness in in vivo models. Single cell transcriptomic analysis of these tumours and of cerebral organoids derived from expanded potential stem cells overexpressing METTL7B identified a regulatory role for the gene in the neural stem cells to astrocyte differentiation trajectory. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
16 Samples

Download data: CSV

Series

Accession:: GSE242328

ID:: 200242328

PubMed Full text in PMC Similar studies

Select item 20024232618.

METTL7B is an essential epigenetic regulator of lineage specification in glioblastoma [ChIPseq]

(Submitter supplied) Glioblastomas are the most common malignant brain tumours in adults; they are highly aggressive, heterogeneous and plastic. We have identified METTL7B as an essential regulator of lineage specification in glioblastoma, with impact on both tumour size and invasiveness in in vivo models. Single cell transcriptomic analysis of these tumours and of cerebral organoids derived from expanded potential stem cells overexpressing METTL7B identified a regulatory role for the gene in the neural stem cells to astrocyte differentiation trajectory. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL24676
32 Samples

Download data: BEDGRAPH, BW

Series

Accession:: GSE242326

ID:: 200242326

PubMed Full text in PMC Similar studies

Select item 20005125319.

Discovery of PDE7B as a novel effector of GBM growth by computational deconvolution of an in vitro physical coculture system

(Submitter supplied) Cell-to-cell interactions between tumor cells and their microenvironment are critical determinants of tumor tissue biology and therapeutic responses. Interactions between glioblastoma (GBM) cells and endothelial cells (ECs) establish a purported stem cell niche. We hypothesized that genes that mediate these interactions would be important, particularly as therapeutic targets. Using a novel computational approach to deconvoluting expression data from mixed physical coculture of GBM cells and ECs, we identified upregulation of the cAMP specific phosphodiesterase PDE7B in GBM cells in response to ECs. more...