Similar studies for GEO DataSets (Select 200100808) - GEO DataSets

Select item 2001008081.

Distinct cellular mechanisms underlie anti-CTLA-4 and anti-PD-1 checkpoint blockade [WES]

(Submitter supplied) Immune checkpoint blockade is able to achieve durable responses in a subset of patients, however we lack a satisfying comprehension of the underlying mechanisms of anti-CTLA-4 and anti-PD-1 induced tumor rejection. To address these issues we utilized mass cytometry to comprehensively profile the effects of checkpoint blockade on tumor immune infiltrates in human melanoma and murine tumor models. These analyses reveal a spectrum of tumor infiltrating T cell populations that are highly similar between tumor models and indicate that checkpoint blockade targets only specific subsets of tumor infiltrating T cell populations. more...

Organism:: Mus musculus

Type:: Genome variation profiling by high throughput sequencing

Platform:: GPL13112
2 Samples

Download data: TXT

Series

Accession:: GSE100808

ID:: 200100808

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001008092.

Distinct cellular mechanisms underlie anti-CTLA-4 and anti-PD-1 checkpoint blockade

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome variation profiling by high throughput sequencing

Platforms:: GPL13112 GPL21103
11 Samples

Download data: TXT

Series

Accession:: GSE100809

ID:: 200100809

PubMed Full text in PMC Similar studies

Select item 2001008073.

Distinct cellular mechanisms underlie anti-CTLA-4 and anti-PD-1 checkpoint blockade [RNA-seq]

(Submitter supplied) Immune checkpoint blockade is able to achieve durable responses in a subset of patients, however we lack a satisfying comprehension of the underlying mechanisms of anti-CTLA-4 and anti-PD-1 induced tumor rejection. To address these issues we utilized mass cytometry to comprehensively profile the effects of checkpoint blockade on tumor immune infiltrates in human melanoma and murine tumor models. These analyses reveal a spectrum of tumor infiltrating T cell populations that are highly similar between tumor models and indicate that checkpoint blockade targets only specific subsets of tumor infiltrating T cell populations. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21103
9 Samples

Download data: CSV

Series

Accession:: GSE100807

ID:: 200100807

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001146314.

Tumor-resident memory-like CD8 T cells represent an essential cellular target for cancer immunotherapy

(Submitter supplied) Persistent exposure to high levels of antigen results in the progressive exhaustion of T cells and has been thought to preclude the formation of memory. In contrast to the latter assumption, we show here that tumor-specific CD8 T cells residing in the tumor microenvironment include a Tcf1 expressing sub population that has key characteristics of central memory cells, lack an effector cell signature but display hallmarks of exhausted T cells, including the expression co-inhibitory receptors such as PD1. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
11 Samples

Download data: TXT

Series

Accession:: GSE114631

ID:: 200114631

PubMed Similar studies SRA Run Selector

Select item 2001229695.

Checkpoint blockade immunotherapy induces dynamic changes in PD-1-CD8+ tumor-infiltrating T cells

(Submitter supplied) An improved understanding of the anti-tumor CD8+ T cell response after checkpoint blockade would enable more informed and effective therapeutic strategies. Here we examined the dynamics of the effector response of CD8+ tumor-infiltrating lymphocytes (TILs) after checkpoint blockade therapy. Bulk and single-cell RNA profiles of CD8+ TILs after combined Tim-3+PD-1 blockade in preclinical models revealed significant changes in the transcriptional profile of PD-1? TILs. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL19057 GPL17021
28 Samples

Download data: TXT

Series

Accession:: GSE122969

ID:: 200122969

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2002737186.

Combination anti-PD-1 and anti-CTLA-4 therapy generates waves of clonal responses that include progenitor-exhausted CD8 T cells [dataset 4]

(Submitter supplied) Combination checkpoint blockade with anti-PD-1 and anti-CTLA-4 antibodies has shown promising efficacy in melanoma. However, the underlying mechanism in humans remains unclear. We performed RNA+TCR single-cell analysis across time in 36 stage IV melanoma patients treated with anti-PD-1, anti-CTLA-4, or combination therapy. We developed the algorithm Cyclone to track temporal clonal dynamics and underlying cell states. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
6 Samples

Download data: MTX, TSV

Series

Accession:: GSE273718

ID:: 200273718

PubMed

Select item 2002729937.

Combination anti-PD-1 and anti-CTLA-4 therapy generates waves of clonal responses that include progenitor-exhausted CD8 T cells [dataset 1]

(Submitter supplied) Combination checkpoint blockade with anti-PD-1 and anti-CTLA-4 antibodies has shown promising efficacy in melanoma. However, the underlying mechanism in humans remains unclear. We performed RNA+TCR single-cell analysis across time in 36 stage IV melanoma patients treated with anti-PD-1, anti-CTLA-4, or combination therapy. We developed the algorithm Cyclone to track temporal clonal dynamics and underlying cell states. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Other

Platform:: GPL24676
360 Samples

Download data: CSV, FASTA, MTX, RDS, TSV

Series

Accession:: GSE272993

ID:: 200272993

PubMed

Select item 2002727358.

Combination anti-PD-1 and anti-CTLA-4 therapy generates waves of clonal responses that include progenitor-exhausted CD8 T cells [dataset 3]

(Submitter supplied) Combination checkpoint blockade with anti-PD-1 and anti-CTLA-4 antibodies has shown promising efficacy in melanoma. However, the underlying mechanism in humans remains unclear. We performed RNA+TCR single-cell analysis across time in 36 stage IV melanoma patients treated with anti-PD-1, anti-CTLA-4, or combination therapy. We developed the algorithm Cyclone to track temporal clonal dynamics and underlying cell states. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
8 Samples

Download data: CSV, FASTA, MTX, TSV

Series

Accession:: GSE272735

ID:: 200272735

PubMed

Select item 2002727349.

Combination anti-PD-1 and anti-CTLA-4 therapy generates waves of clonal responses that include progenitor-exhausted CD8 T cells [dataset 2]

(Submitter supplied) Combination checkpoint blockade with anti-PD-1 and anti-CTLA-4 antibodies has shown promising efficacy in melanoma. However, the underlying mechanism in humans remains unclear. We performed RNA+TCR single-cell analysis across time in 36 stage IV melanoma patients treated with anti-PD-1, anti-CTLA-4, or combination therapy. We developed the algorithm Cyclone to track temporal clonal dynamics and underlying cell states. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
40 Samples

Download data: CSV, FASTA, MTX, TSV

Series

Accession:: GSE272734

ID:: 200272734

PubMed

Select item 20007792410.

Gene Expression Profiling of human monocytes: Combination Therapy with Anti–CTLA-4 and Anti–PD-1 Leads to Distinct Immunologic Changes In Vivo

(Submitter supplied) Transcriptome analysis of human peripheral blood monocytes Combination therapy concurrently targeting PD-1 and CTLA-4 immune checkpoints leads to remarkable antitumor effects. Although both PD-1 and CTLA-4 dampen the T cell activation, the in vivo effects of these drugs in humans remain to be clearly defined. To better understand biologic effects of therapy, we analyzed blood/tumor tissue from patients undergoing single or combination immune checkpoint blockade. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL17585
39 Samples

Download data: CEL

Series

Accession:: GSE77924

ID:: 200077924

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20007771411.

Gene Expression Profiling of human T cells: Combination Therapy with Anti–CTLA-4 and Anti–PD-1 Leads to Distinct Immunologic Changes In Vivo

(Submitter supplied) Transcriptome analysis of human peripheral blood T cells Combination therapy concurrently targeting PD-1 and CTLA-4 immune checkpoints leads to remarkable antitumor effects. Although both PD-1 and CTLA-4 dampen the T cell activation, the in vivo effects of these drugs in humans remain to be clearly defined. To better understand biologic effects of therapy, we analyzed blood/tumor tissue from patients undergoing single or combination immune checkpoint blockade. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL17585
40 Samples

Download data: CEL, CHP

Series

Accession:: GSE77714

ID:: 200077714

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20010169012.

Sequencing of tumor associated (B16f10-OVA) mir-155 Wt or deficient CD4+ and CD8+ T cells

(Submitter supplied) Tumor associated CD4+ and CD8+ T cells were sorted from B16f10 OVA expressing tumors in miR-155 flox, miR-155 flox CD4Cre+, and miR-155 flox CD4Cre+ mice treated with immune checkpoint blocking (ICB) antibodies by flow sorting on CD45+CD3+CD4+ cells and CD45+ CD3+CD8+ cells. RNA was collected from these cells to perform RNA sequencing of total RNA.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
18 Samples

Download data: TXT

Series

Accession:: GSE101690

ID:: 200101690

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20010948513.

Anti-PD-1/anti-CTLA-4 efficacy in melanoma brain metastases depends on extracranial disease and augmentation of CD8+ T cell trafficking

(Submitter supplied) Intracranial B16 melanoma tumors isolated from C57Bl6 mice were analyzed by mRNAseq. Four experimental groups were analyzed: (1) Mice with intracranial tumors receiving IgG; (2) Mice with intracranial tumors receiving anti-PD-1 plus anti-CTLA-4 therapy; (3) Mice with intracranial plus extracranial tumors receiving IgG; (4) Mice with intracranial plus extracranial tumors receiving anti-PD-1 plus anti-CTLA-4 therapy. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
12 Samples

Download data: TXT

Series

Accession:: GSE109485

ID:: 200109485

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20015489814.

Single cell RNA-sequencing of Tumor-Associated High Endothelial Cells (TA-HECs) and comparison to their counterparts in homeostatic and inflamed mouse lymph nodes

(Submitter supplied) High endothelial venules (HEVs) are specialized postcapillary venules that mediate lymphocyte trafficking from the blood into lymph nodes. HEV-like blood vessels are found in solid tumors in association with CD8+ T cell infiltration.This study uses single cell RNA-sequencing using the Fluidigm C1 system as a method to evaluate the transcriptome in lymph node and tumor-associated HEV endothelial cells (LN-HECs and TA-HECs). more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21493
257 Samples

Download data: TXT

Series

Accession:: GSE154898

ID:: 200154898

PubMed Similar studies SRA Run Selector

Select item 20013229715.

Intratumoral TFR cells curtail anti-PD-1 treatment efficacy

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens; Mus musculus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL24247 GPL16791 GPL24676
62 Samples

Download data

Series

Accession:: GSE132297

ID:: 200132297

PubMed Full text in PMC Similar studies

Select item 20013229616.

Intratumoral TFR cells curtail anti-PD-1 treatment efficacy [mouse]

(Submitter supplied) Follicular regulatory T cells (TFR cells) and their functional role in cancer have been completely disregarded so far. Our data identify that as a critical oversight, as these cells account for a substantial proportion of tumor-infiltrating CD4+ T cells

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
42 Samples

Download data: TXT

Series

Accession:: GSE132296

ID:: 200132296

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20013229517.

Intratumoral TFR cells curtail anti-PD-1 treatment efficacy [human]

(Submitter supplied) Follicular regulatory T cells (TFR cells) and their functional role in cancer have been completely disregarded so far. Our data identify that as a critical oversight, as these cells account for a substantial proportion of tumor-infiltrating CD4+ T cells

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL16791 GPL24676
20 Samples

Download data: TXT

Series

Accession:: GSE132295

ID:: 200132295

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20006550318.

Radiation and Dual Checkpoint Blockade Activates Non-Redundant Mechanisms in Cancer

(Submitter supplied) Response to immune checkpoint inhibitors may be improved through combinations with each other and other therapies, raising questions about non-redundancy and resistance. We report results from parallel studies of melanoma patients and mice treated with anti-CTLA4 and radiation (RT). Although combined treatment improved responses, resistance was common. Computational analyses of immune and transcriptomic profiles (provided here) revealed that resistance in mice was due to upregulation of tumor PD-L1 that drives T cell exhaustion. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platforms:: GPL6246 GPL16570
14 Samples

Download data: CEL

Series

Accession:: GSE65503

ID:: 200065503

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20018556619.

Combinatorial Immunotherapy Induces Tumor Infiltrating CD8+ T Cells with Distinct Functional, Migratory, and Stem-Like Properties III

(Submitter supplied) This study reveals supeior efficiacy of triple combination treatment (TCT) based on anti-PD-(L)1 and anti-4-1BB/OX40 and describes immunological mechanisms underlying synergism between the treatment components