Similar studies for GEO DataSets (Select 200126070) - GEO DataSets

Select item 2001260701.

CRISPR screening reveals targets to reprogram long-lived effector CD8+ T cells for cancer therapy. [ATAC-Seq]

(Submitter supplied) CD8+ T cells can be reprogrammed for better persistence and robust effector function in TME. By performing an in vivo pooled CRISPR-Cas9 mutagenesis screening of metabolism-associated factors, we identify Regnase-1 as a major negative regulator of antitumor responses, whose deficiency results in drastically increased CD8+ T cell accumulation in tumors

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL21103
8 Samples

Download data: BW

Series

Accession:: GSE126070

ID:: 200126070

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001370162.

CRISPR screening reveals targets to reprogram long-lived effector CD8+ T cells for cancer therapy [microarray]

(Submitter supplied) CD8+ T cells can be reprogrammed for better persistence and robust effector function in TME. By performing an in vivo pooled CRISPR-Cas9 mutagenesis screening of metabolism-associated factors, we identify Regnase-1 as a major negative regulator of antitumor responses, whose deficiency results in drastically increased CD8+ T cell accumulation in tumors We used microarrays to compare the global transcription profiles of Regnase1-null, Ptpn2/Regnase1-null and Socs1/Regnase1-null tumor infiltrating CD8+ T cell populations

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL23038
6 Samples

Download data: CEL

Series

Accession:: GSE137016

ID:: 200137016

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Select item 2001370153.

CRISPR screening reveals targets to reprogram long-lived effector CD8+ T cells for cancer therapy [scRNA-seq]

(Submitter supplied) CD8+ T cells can be reprogrammed for better persistence and robust effector function in TME. By performing an in vivo pooled CRISPR-Cas9 mutagenesis screening of metabolism-associated factors, we identify Regnase-1 as a major negative regulator of antitumor responses, whose deficiency results in drastically increased CD8+ T cell accumulation in tumors

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21103
4 Samples

Download data: TAR

Series

Accession:: GSE137015

ID:: 200137015

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Select item 2001370144.

CRISPR screening reveals targets to reprogram long-lived effector CD8+ T cells for cancer therapy [ATAC-seq]

(Submitter supplied) CD8+ T cells can be reprogrammed for better persistence and robust effector function in TME. By performing an in vivo pooled CRISPR-Cas9 mutagenesis screening of metabolism-associated factors, we identify Regnase-1 as a major negative regulator of antitumor responses, whose deficiency results in drastically increased CD8+ T cell accumulation in tumors

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL21103
14 Samples

Download data: TXT

Series

Accession:: GSE137014

ID:: 200137014

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001260725.

CRISPR screening reveals targets to reprogram long-lived effector CD8+ T cells for cancer therapy.

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array; Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL23038 GPL21103
50 Samples

Download data: BW, CEL, TAR, TXT

Series

Accession:: GSE126072

ID:: 200126072

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001260716.

CRISPR screening reveals targets to reprogram long-lived effector CD8+ T cells for cancer therapy. [RNA-Seq]

(Submitter supplied) CD8+ T cells can be reprogrammed for better persistence and robust effector function in TME. By performing an in vivo pooled CRISPR-Cas9 mutagenesis screening of metabolism-associated factors, we identify Regnase-1 as a major negative regulator of antitumor responses, whose deficiency results in drastically increased CD8+ T cell accumulation in tumors

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21103
18 Samples

Download data: TXT

Series

Accession:: GSE126071

ID:: 200126071

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Select item 2001714427.

Regnase-1 suppresses TCF-1+ precursor exhausted T cell formation to limit CAR T cell responses against ALL [WGBS]

(Submitter supplied) Defciency of Regnase-1 enhances CAR-T cell persistence and anti-tumor ability

Organism:: Mus musculus

Type:: Methylation profiling by high throughput sequencing

Platform:: GPL24247
5 Samples

Download data: BED

Series

Accession:: GSE171442

ID:: 200171442

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Select item 2001550218.

Regnase-1 suppresses TCF-1+ precursor exhausted T cell formation to limit CAR T cell responses against ALL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array; Methylation profiling by high throughput sequencing

Platforms:: GPL24247 GPL23038
40 Samples

Download data: BED, CEL

Series

Accession:: GSE155021

ID:: 200155021

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Select item 2001550209.

Improved persistence and expanded TPEX formation in Regnase-1 KO CAR T cells is TCF-1-dependent

(Submitter supplied) transcriptional profiling was performed on Regnase-1 KO CAR and Regnase-1 TCF-1 DKO CAR T cells isolated 7days after co-transfer into tumor bearing mice. TCF-1 deficiency in Regnase-1 KO CAR T cells led to reduced long-term persistence and memory-like phenotype.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL23038
10 Samples

Download data: CEL

Series

Accession:: GSE155020

ID:: 200155020

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Select item 20015494210.

Regnase-1 KO CAR T cell reprogramed to memory-like cells

(Submitter supplied) transcriptional profiling was performed on WT and KO CAR T cells isolated 21 days after co-transfer into tumor bearing mice. Regnase-1 KO CAR T cell reprogramed to memory-like cells long-term after tumor priming in vivo compared to WT CAR T cells

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL23038
6 Samples

Download data: CEL

Series

Accession:: GSE154942

ID:: 200154942

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Select item 20015485911.

Regnase-1 suppresses TCF-1+ precursor exhausted T cell formation to limit CAR T cell responses against ALL [Microarray Expression]

(Submitter supplied) transcriptional profiling was performed on WT and KO CAR T cells isolated 7 days after co-transfer into mice with or without tumors. Regnase-1 KO CAR T cells undergoing a tumor-dependent shift from an effector to memory-like phenotype

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL23038
19 Samples

Download data: CEL

Series

Accession:: GSE154859

ID:: 200154859

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Select item 20006562712.

Expression data from human melanoma specific CD8+ T cell clones

(Submitter supplied) The optimal T cell attributes for the adoptive immunotherapy of cancer and viral diseases are currently unclear. Recent adoptive transfer clinical trials using ex vivo expanded tumor infiltrating lymphocytes has provided evidence that differentiated effector T cells can mediate durable responses in selected cancer patients. The capacity of these transferred cells to persist in the host was found to strongly correlate with their clinical activity. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
10 Samples

Download data: CEL

Series

Accession:: GSE65627

ID:: 200065627

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Select item 20010809213.

ATAC-Seq of CD8+ T cell terminal effector and memory precursor subsets during LCMV infection

(Submitter supplied) Tissue-resident memory CD8+ T cells (Trm) are positioned at common sites of pathogen exposure where they elicit rapid and robust protective immune responses. However, the molecular signals controlling Trm differentiation and homeostasis are not fully understood. Here we show that mouse Trm precursor cells represent a unique CD8+ T cell subset that is distinct from the precursors of circulating memory populations at the levels of gene expression and chromatin accessibility. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL17021
4 Samples

Download data: BEDGRAPH

Series

Accession:: GSE108092

ID:: 200108092

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Select item 20010739514.

Runx3 programs CD8+ T cell residency in non-lymphoid tissues and tumours

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL6246 GPL17021
44 Samples

Download data: BEDGRAPH, CEL

Series

Accession:: GSE107395

ID:: 200107395

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Select item 20010737315.

ATAC-Seq of CD8+ T cell subsets during LCMV infection

(Submitter supplied) Tissue-resident memory CD8+ T cells (Trm) are positioned at common sites of pathogen exposure where they elicit rapid and robust protective immune responses. However, the molecular signals controlling Trm differentiation and homeostasis are not fully understood. Here we show that mouse Trm precursor cells represent a unique CD8+ T cell subset that is distinct from the precursors of circulating memory populations at the levels of gene expression and chromatin accessibility. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL17021
6 Samples

Download data: BEDGRAPH

Series

Accession:: GSE107373

ID:: 200107373

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Select item 20010728916.

RNA-seq of tumor residing CD8+ T cells overexpressing Runx3

(Submitter supplied) Tissue-resident memory CD8+ T cells (Trm) are positioned at common sites of pathogen exposure where they elicit rapid and robust protective immune responses1,2. However, the molecular signals controlling Trm differentiation and homeostasis are not fully understood. Here we show that mouse Trm precursor cells represent a unique CD8+ T cell subset that is distinct from the precursors of circulating memory populations at the levels of gene expression and chromatin accessibility. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
6 Samples

Download data: TXT

Series

Accession:: GSE107289

ID:: 200107289

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Select item 20010728117.

RNA-Seq of CD8+ T cell subsets during LCMV infection

(Submitter supplied) Tissue-resident memory CD8+ T cells (Trm) are positioned at common sites of pathogen exposure where they elicit rapid and robust protective immune responses1,2. However, the molecular signals controlling Trm differentiation and homeostasis are not fully understood. Here we show that mouse Trm precursor cells represent a unique CD8+ T cell subset that is distinct from the precursors of circulating memory populations at the levels of gene expression and chromatin accessibility. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
8 Samples

Download data: TXT

Series

Accession:: GSE107281

ID:: 200107281

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20010727818.

Microarray analysis of CD8+ T cell subsets during LCMV infection

(Submitter supplied) Tissue-resident memory CD8+ T cells (Trm) are positioned at common sites of pathogen exposure where they elicit rapid and robust protective immune responses1,2. However, the molecular signals controlling Trm differentiation and homeostasis are not fully understood. Here we show that mouse Trm precursor cells represent a unique CD8+ T cell subset that is distinct from the precursors of circulating memory populations at the levels of gene expression and chromatin accessibility. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6246
20 Samples

Download data: CEL

Series

Accession:: GSE107278

ID:: 200107278

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20010610719.

RNA-Seq of CD8+ T cells expressing different levels of Runx3 in a cell culture model of CTL differentiation

(Submitter supplied) Tissue-resident memory CD8+ T cells (Trm) are positioned at common sites of pathogen exposure where they elicit rapid and robust protective immune responses. However, the molecular signals controlling Trm differentiation and homeostasis are not fully understood. Here we show that mouse Trm precursor cells represent a unique CD8+ T cell subset that is distinct from the precursors of circulating memory populations at the levels of gene expression and chromatin accessibility. more...