Similar studies for GEO DataSets (Select 200209994) - GEO DataSets

Select item 2002099941.

Transcriptional and epigenetic reprogramming mediated by chronic IL1β exposure drives self-renewal ability and myeloid priming in TET2 deficient stem and progenitor cells [10x_scRNAseq]

(Submitter supplied) Clonal hematopoiesis (CH) increases risk for the development of hematological malignancy and cardiovascular disease. IL1β is elevated in patients with CH and its inhibition mitigates cardiovascular risk in murine models with Tet2 loss-of-function. How IL1β alters population dynamics of hematopoietic cells upon Tet2 deletion (Tet2-KO) is not well understood. We demonstrated IL1β expands Tet2-KO neutrophils, monocytes/macrophages, and long-term hematopoietic stem cells with reduced lymphopoiesis. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
16 Samples

Download data: MTX, TSV, TXT

Series

Accession:: GSE209994

ID:: 200209994

PubMed Full text in PMC Similar studies

Select item 2002100262.

Transcriptional and epigenetic reprogramming mediated by chronic IL1β exposure drives self-renewal ability and myeloid priming in TET2 deficient stem and progenitor cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing

Platform:: GPL24247
64 Samples

Download data: COV

Series

Accession:: GSE210026

ID:: 200210026

PubMed Full text in PMC Similar studies

Select item 2002100253.

Transcriptional and epigenetic reprogramming mediated by chronic IL1β exposure drives self-renewal ability and myeloid priming in TET2 deficient stem and progenitor cells [Bisulfite-Seq]

(Submitter supplied) Clonal hematopoiesis (CH) increases risk for the development of hematological malignancy and cardiovascular disease. IL1β is elevated in patients with CH and its inhibition mitigates cardiovascular risk in murine models with Tet2 loss-of-function. How IL1β alters population dynamics of hematopoietic cells upon Tet2 deletion (Tet2-KO) is not well understood. We demonstrated IL1β expands Tet2-KO neutrophils, monocytes/macrophages, and long-term hematopoietic stem cells with reduced lymphopoiesis. more...

Organism:: Mus musculus

Type:: Methylation profiling by high throughput sequencing

Platform:: GPL24247
48 Samples

Download data: COV

Series

Accession:: GSE210025

ID:: 200210025

PubMed Full text in PMC Similar studies

Select item 2001481324.

RNA-Seq of TET2 uniallelic mutated and wild type CFU colonies from rhesus macaque HSPCs

(Submitter supplied) Gene expression profile of individual CFU-GM colonies identified as uniallelic TET2 mutant versus TET2 wild type was analyzed via RNA-Seq to verify the impact of TET2 editing on gene expression in the rhesus macaque clonal hematopoiesis model.

Organism:: Macaca mulatta

Type:: Expression profiling by high throughput sequencing

Platform:: GPL23804
6 Samples

Download data: TXT

Series

Accession:: GSE148132

ID:: 200148132

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001468125.

Tet2-mediated clonal hematopoiesis in nonconditioned mice accelerates age-associated cardiac dysfunction

(Submitter supplied) Clonal hematopoiesis of indeterminate potential is prevalent in elderly individuals and associated with increased risks of all-cause mortality and cardiovascular disease. However, mouse models to study the dynamics of clonal hematopoiesis and its consequences on the cardiovascular system under homeostatic conditions are lacking. We used a model of clonal hematopoiesis using adoptive transfer of unfractionated ten-eleven translocation 2-mutant (Tet2-mutant) bone marrow cells into nonirradiated mice. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21103
6 Samples

Download data: TSV

Series

Accession:: GSE146812

ID:: 200146812

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2002323846.

Identify the key signaling pathway involved in the Tet2 deficiency-induced clonal hematopoiesis

(Submitter supplied) To investigate the signaling pathway required for the Tet2 mutant associated clonal hematopoiesis, we identified the activated signaling pathway in Tet2-deficient hematopoietic stem/progenitor cells compared to WT cells and using transgentic mouse model to validate our findings. In short, the cGAS-STING pathway is activated in Tet2-deficient HSPCs and promotes the development of CH associated with Tet2 deficiency.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
55 Samples

Download data: CSV, TXT

Series

Accession:: GSE232384

ID:: 200232384

PubMed Full text in PMC Similar studies

Select item 2001371267.

Genome-wide maping of chromatin state and gene exoression in hematopoietic stem and progenitor cells.

(Submitter supplied) We report the application of H3K27me3 ChI-seq assays in hematopoietic stem and progenitors cells (HSPCs) from p53+/+ and p53R248W/+ mutant mice. We also performed RNA-seq assays to examine the impact of p53 on gene expression in hematopoietic stem and progenitor cells.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platforms:: GPL19057 GPL21103
11 Samples

Download data: BW, TXT

Series

Accession:: GSE137126

ID:: 200137126

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001989088.

Restoration of genome-wide 5-hydroxymethylation by azacitidine and ascorbate in TET2-deficient human pre-leukemic HSPCs

(Submitter supplied) The conversion of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) is a key step in DNA demethylation that is mediated by ten-eleven-translocation (TET) enzymes, which require ascorbate/vitamin C. Here, we report the 5hmC landscape of normal hematopoiesis and identify cell type-specific 5hmC profiles associated with active transcription and chromatin accessibility of key hematopoietic regulators. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Other

Platforms:: GPL21697 GPL24676
326 Samples

Download data: TSV

Series

Accession:: GSE198908

ID:: 200198908

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001544939.

p300 suppresses the transition of myelodysplastic syndrome to acute myeloid leukemia [ChIP-seq II]

(Submitter supplied) The p300 lysine acetyltransferase (KAT) can function as an oncogene or a tumor suppressor in hematologic malignancies. We have identified a tumor suppressor role for p300 in myelodysplastic syndrome (MDS) driven by Tet2 deficiency. Compared to Tet2-null hematopoietic stem and progenitor cells (HSPCs), HSPCs lacking both p300 and Tet2 (double knock out, DKO) displayed enhanced proliferation and impaired differentiation. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL19057
2 Samples

Download data: BIGWIG, NARROWPEAK

Series

Accession:: GSE154493

ID:: 200154493

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20014587810.

p300 suppresses the transition of myelodysplastic syndrome to acute myeloid leukemia

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Methylation profiling by high throughput sequencing

4 related Platforms
74 Samples

Download data: BIGWIG, BW, NARROWPEAK

Series

Accession:: GSE145878

ID:: 200145878

PubMed Full text in PMC Similar studies

Select item 20014587711.

p300 suppresses the transition of myelodysplastic syndrome to acute myeloid leukemia [DIP-seq]

(Submitter supplied) The p300 lysine acetyltransferase (KAT) can function as an oncogene or a tumor suppressor in hematologic malignancies. We have identified a tumor suppressor role for p300 in myelodysplastic syndrome (MDS) driven by Tet2 deficiency. Compared to Tet2-null hematopoietic stem and progenitor cells (HSPCs), HSPCs lacking both p300 and Tet2 (double knock out, DKO) displayed enhanced proliferation and impaired differentiation. more...

Organism:: Mus musculus

Type:: Methylation profiling by high throughput sequencing

Platform:: GPL13112
24 Samples

Download data: BW

Series

Accession:: GSE145877

ID:: 200145877

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20014587612.

p300 suppresses the transition of myelodysplastic syndrome to acute myeloid leukemia [ChIP-seq]

(Submitter supplied) The p300 lysine acetyltransferase (KAT) can function as an oncogene or a tumor suppressor in hematologic malignancies. We have identified a tumor suppressor role for p300 in myelodysplastic syndrome (MDS) driven by Tet2 deficiency. Compared to Tet2-null hematopoietic stem and progenitor cells (HSPCs), HSPCs lacking both p300 and Tet2 (double knock out, DKO) displayed enhanced proliferation and impaired differentiation. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL19057
20 Samples

Download data: BW, NARROWPEAK

Series

Accession:: GSE145876

ID:: 200145876

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20014587513.

p300 suppresses the transition of myelodysplastic syndrome to acute myeloid leukemia [ATAC-Seq]

(Submitter supplied) The p300 lysine acetyltransferase (KAT) can function as an oncogene or a tumor suppressor in hematologic malignancies. We have identified a tumor suppressor role for p300 in myelodysplastic syndrome (MDS) driven by Tet2 deficiency. Compared to Tet2-null hematopoietic stem and progenitor cells (HSPCs), HSPCs lacking both p300 and Tet2 (double knock out, DKO) displayed enhanced proliferation and impaired differentiation. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL24247
16 Samples

Download data: NARROWPEAK

Series

Accession:: GSE145875

ID:: 200145875

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20014581914.

p300 suppresses the transition of myelodysplastic syndrome to acute myeloid leukemia [RNA-Seq]

(Submitter supplied) The p300 lysine acetyltransferase (KAT) can function as an oncogene or a tumor suppressor in hematologic malignancies. We have identified a tumor suppressor role for p300 in myelodysplastic syndrome (MDS) driven by Tet2 deficiency. Compared to Tet2-null hematopoietic stem and progenitor cells (HSPCs), HSPCs lacking both p300 and Tet2 (double knock out, DKO) displayed enhanced proliferation and impaired differentiation. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
12 Samples

Download data: XLSX

Series

Accession:: GSE145819

ID:: 200145819

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20009764015.

Gene expression profiling in pre-leukemic hematopoietic stem cells carrying both NrasG12D/+ and Tet2+/- mutations

(Submitter supplied) By using a genetically accurate mouse model, we demonstrate that endogenous expression of oncogenic N-RasG12D and Tet2 haploinsufficiency collaborate to accelerate CMML development in mice. Gene expression was compared across all genotypes (WT, Tet2+/-, NrasG12D/+ and double mutants) in bone marrow-derived hematopoietic stem cells (CD150+CD48-Lin-Sca1+cKit+) using RNA-seq. N-RasG12D and Tet2 haploinsufficiency cooperate to induce both unique and overlapping effects on HSC gene expression programs.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
12 Samples

Download data: TXT

Series

Accession:: GSE97640

ID:: 200097640

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20011597216.

TET2 binding to enhancers facilitates transcription factor recruitment in hematopoietic cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL21626
66 Samples

Download data: BIGWIG, NARROWPEAK

Series

Accession:: GSE115972

ID:: 200115972

PubMed Full text in PMC Similar studies

Select item 20011596717.

TET2 binding to enhancers facilitates transcription factor recruitment in hematopoietic cells [RNA-Seq]

(Submitter supplied) The epigenetic regulator TET2 is frequently mutated in hematological diseases. Mutations have been shown to arise in hematopoietic stem cells early in disease development, lead to altered DNA methylation landscapes and to an increased risk of hematopoietic malignancy. Here, we show by genome-wide mapping of TET2 binding sites in different cell types that TET2 localizes to regions of open chromatin and cell-type specific enhancers. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21626
16 Samples

Download data: TXT

Series

Accession:: GSE115967

ID:: 200115967

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20011596518.

TET2 binding to enhancers facilitates transcription factor recruitment in hematopoietic cells [TET2 ChIP-seq hematopoietic cells]

(Submitter supplied) The epigenetic regulator TET2 is frequently mutated in hematological diseases. Mutations have been shown to arise in hematopoietic stem cells early in disease development, lead to altered DNA methylation landscapes and to an increased risk of hematopoietic malignancy. Here, we show by genome-wide mapping of TET2 binding sites in different cell types that TET2 localizes to regions of open chromatin and cell-type specific enhancers. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL21626
12 Samples

Download data: TXT

Series

Accession:: GSE115965

ID:: 200115965

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20011596419.

TET2 binding to enhancers facilitates transcription factor recruitment in hematopoietic cells [TET2 ChIP-seq ES cells]

(Submitter supplied) The epigenetic regulator TET2 is frequently mutated in hematological diseases. Mutations have been shown to arise in hematopoietic stem cells early in disease development, lead to altered DNA methylation landscapes and to an increased risk of hematopoietic malignancy. Here, we show by genome-wide mapping of TET2 binding sites in different cell types that TET2 localizes to regions of open chromatin and cell-type specific enhancers. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL21626
10 Samples

Download data: BIGWIG, NARROWPEAK

Series

Accession:: GSE115964

ID:: 200115964

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20011596220.

TET2 binding to enhancers facilitates transcription factor recruitment in hematopoietic cells [ATAC-Seq]

(Submitter supplied) The epigenetic regulator TET2 is frequently mutated in hematological diseases. Mutations have been shown to arise in hematopoietic stem cells early in disease development, lead to altered DNA methylation landscapes and to an increased risk of hematopoietic malignancy. Here, we show by genome-wide mapping of TET2 binding sites in different cell types that TET2 localizes to regions of open chromatin and cell-type specific enhancers. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL21626
28 Samples

Download data: BIGWIG

Series

Accession:: GSE115962

ID:: 200115962

PubMed Full text in PMC Similar studies SRA Run Selector

GEO DataSets

Functional Genomics Studies

Result Filters

Entry type

Organism

Study type

Author

Attribute name

Publication dates

Custom date range

Additional filters

Send to:

Links from GEO DataSets

Items: 20

Send to:

Supplemental Content

Find related data

Important Links

Recent activity