GEO DataSets

Analysis of dysplastic lung cells and transgenic but morphologically unaltered lung cells, both harvested from SP-C/c-raf transgenics. Normal lung from non-transgenic littermates also examined. Results provide insight into molecular mechanisms underlying an early stage of lung cancer development.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 age, 3 disease state, 2 gender, 2 genotype/variation sets

Platform:

GPL1261

Series:

GSE13963

15 Samples

Download data: CEL, CHP

(Submitter supplied) Background: Lung cancer is a multistage process with poor prognosis and high morbidity. Importantly, the genetics of dysplasia, a facultative cancer, at the edge of malignant transformation is unknown. Results: We employed laser microdissection to harvest dysplastic as opposed to transgenic but otherwise morphologically unaltered epithelium and compared findings to non-transgenic lung. We then employed microarrays to search genome wide for gene regulatory networks. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3825

Platform:

GPL1261

15 Samples

Download data: CEL, CHP

(Submitter supplied) Lung cancer is a leading cause of deaths in the world. There is a need to improve an understanding of mechanisms of malignant transformation and to develop genetic markers of disease for better and targeted therapies. Here, we report findings with a transgenic disease model where targeted expression of c-raf to respiratory epithelium induced adenocarcinomas. Specifically, by use of laser microdissection we harvested either tumor or transgenic and non-transgenic but otherwise morphologically unaltered cells. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3826

Platform:

GPL1261

15 Samples

Download data: CEL, CHP

Analysis of lung tumor cells and transgenic but morphologically unaltered lung cells, both harvested from SP-C/c-raf transgenics. Normal lung from non-transgenic littermates also examined. Results provide insight into molecular mechanisms underlying the progression from lung dysplasia to cancer.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 7 age, 3 disease state, 2 gender, 2 genotype/variation sets

Platform:

GPL1261

Series:

GSE14277

15 Samples

Download data: CEL, CHP

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

synthetic construct; Mus musculus

Type:

Non-coding RNA profiling by array

Platforms:

GPL8786 GPL13493

42 Samples

Download data: CEL, TXT

(Submitter supplied) In this study we analyzed the expression of miRNAs in the lungs of SP-C/c-raf transgenic mice. The transgene is under the transcriptional control of the surfactant protein C (SP-C) promoter and consists of the oncogenically activated NH2-terminal deletion mutant c-Raf-1-BxB. Overall this study aims at identifying miRNAs regulated in precursor lesions of lung cancer.

Organism:

Mus musculus

Type:

Non-coding RNA profiling by array

Platform:

GPL13493

24 Samples

Download data: TXT

(Submitter supplied) In this study we analyzed the expression of miRNAs in the lungs of SP-C/c-raf transgenic mice. The transgene is under the transcriptional control of the surfactant protein C (SP-C) promoter and consists of the oncogenically activated NH2-terminal deletion mutant c-Raf-1-BxB. Overall this study aims at identifying miRNAs regulated in precursor lesions of lung cancer.

Organism:

synthetic construct; Mus musculus

Type:

Non-coding RNA profiling by array

Platform:

GPL8786

18 Samples

Download data: CEL

(Submitter supplied) To study a complex network of gene expression changes underlying c-Myc-triggered carcinogenesis in lung we performed oligonucleotide array analysis of solid lung adenocarcinomas which developed in transgenic mice due to constitutive expression of c- Myc in alveolar type II epithelial cells and compared them with the non-transgenic lung as a control. The microarray analysis yielded 162 up regulated and 301 down regulated genes. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL81

14 Samples

Download data: CEL, CHP

(Submitter supplied) To examine the possibility that biochemical or molecular signatures of endometrium may prove to be more useful, we have investigated whole genome molecular phenotyping (54,600 genes/ESTs) of this tissue sampled across the cycle in 28 normo-ovulatory women, using high-density oligonucleotide microarrays. The results demonstrate that endometrial samples obtained by two different sampling techniques (biopsy and curetting hysterectomy specimens) from subjects who are as normal as possible in a human study and 4 including those with unknown histology, can be classified by their molecular signatures and correspond to known phases of the menstrual cycle with identical results using two independent analytical methods. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS2052

Platform:

GPL570

27 Samples

Download data: CEL

Analysis of the normal endometrium at distinct phases of the menstrual cycle. Results provide insight into whether molecular profiles of the endometrium can distinguish the different phases of the menstrual cycle.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 5 other sets

Platform:

GPL570

Series:

GSE4888

27 Samples

Download data: CEL

(Submitter supplied) Background The in vivo properties of HR-HPV E6 and E7 oncoproteins have been previously evaluated through the generation and characterization of HPV transgenic mouse strains. Although K14E6 transgenic mice develop spontaneous tumors of the skin epithelium, no spontaneous reproductive tract malignancies arise, unless the transgenic mice were treated chronically with 17β-estradiol. Taken together, these findings suggest that E6 performs critical functions in normal adult cervix and skin, highlighting the need to define E6-controlled transcriptional programs in these tissues. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3530

Platform:

GPL8321

8 Samples

Download data: CEL, CHP

Analysis of cervix and skin from 6 week-old, virgin, transgenic females expressing HPV16 E6 oncoprotein. K14E6 transgenics present a more aggressive phenotype in the skin than in the cervix. Results provide insight into the molecular basis for this observed difference in E6 effect.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation, 2 tissue sets

Platform:

GPL8321

Series:

GSE10702

8 Samples

Download data: CEL, CHP

(Submitter supplied) Using a multiorgan metastasis model of human NSCLC cells (ACC-LC319/bone2) in NK cell-depleted SCID mice, we attempted to identify genes involved in the organ-selective nature of lung cancer-metastasis process, especially bone metastasis. Genome-wide gene expression profile of 15 metastatic lesions from three organs (bone, lung and liver) in this mouse model revealed lot of genes that seemed to reflect the organ specificity of metastatic cells. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6480

19 Samples

Download data: TXT

(Submitter supplied) We are investigating the molecular development of squamous cell lung carcinoma based upon analysis of global gene expression profiles representing progressive stages of cancer development, consisting of precancerous, carcinoma-in-situ, and invasive cancer. Keywords: global gene expression analysis, lung cancer development

Organism:

Homo sapiens

Type:

Expression profiling by SAGE

Platform:

GPL4

13 Samples

Download data

(Submitter supplied) A/J mice are genetically predisposed to spontaneous and/or chemically-induced lung tumors while C57BL/6J (B6) mice are resistant. This genetic disparity provides a unique scenario to identify molecular mechanisms associated with the lung response to welding fume at the transcriptome level.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6103

48 Samples

Download data: TXT

(Submitter supplied) Transcriptional profiling of mouse livers comparing control mice with miR-155 transgenic mice that overexpression of miR-155 in the liver

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL13509

6 Samples

Download data: LSR, XLS

(Submitter supplied) Fetal lung development is a complex biological process, which involves temporal and spatial regulations of many genes. To understand molecular mechanisms of this process, we investigated gene expression profiling of lungs at gestational day 18, 19, 20, 21, new born, and adult rats using in-house rat DNA microarray containing 6,000 known genes and 4,000 ESTs. 1,512 genes passed SAM test and 583 genes (402 known genes and 181 ESTs) had a 2-fold change at least at one time point. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1699

54 Samples

Download data

(Submitter supplied) This study characterizes the inflammatory processes in left-sided colitis, pancolitis, and UC-associated dysplasia at the transcriptional level in colonics biopsies in order to identify potential biomarkers and transcripts of importance for the carcinogenic behaviour of chronic inflammation

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

60 Samples

Download data: CEL

(Submitter supplied) To identify early events of erbB2-induced mammary tumorigenesis, we compared datasets from 14 genechip experiments including MMTV-neu tumors, preneoplastic neu mammary gland (adjacent neu), and age-matched, wild-type control mammary glands Keywords = transgenic mouse Keywords = MMTV-neu Keywords = erbB2 Keywords = HER2 Keywords = mammary tumor Keywords: ordered

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS1222

Platform:

GPL81

14 Samples

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Analysis of cancer progression by profiling of preneoplastic mammary glands and tumors of MMTV-neu animals. Activated neu allele placed under the control of mammary tumor virus promoter to enable mammary specific expression. Results provide insight into the early events of Neu induced tumorigenesis.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 disease state, 2 genotype/variation sets

Platform:

GPL81

Series:

GSE2528

14 Samples

Download data