GEO DataSets

Analysis of IL-10+CD8 and IL-10−CD8 T cells from C57Bl/6 Vert-X animals infected with the neurotropic coronavirus J2.2-V-1. IL-10 is a potent anti-inflammatory cytokine. Results provide insight into the role of IL-10+CD8 T cells in the immune response to coronavirus-induced encephalitis.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 cell type sets

Platform:

GPL6246

Series:

GSE25846

6 Samples

Download data: CEL

(Submitter supplied) IL-10 is an anti-inflammatory cytokine that has been shown to be produced by antigen-specific CD8 T cells at the peak of viral encephalitis. We found that IL-10+CD8 T cells are more activated and cytolytic than IL-10-CD8 T cells. We used microarrays to detect gene expression changes in directly ex vivo sorted CNS IL-10+ and IL-10- CD8 T cells from a neurotropic J2.2-V-1-infected mouse.

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4217

Platform:

GPL6246

6 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:

GPL16417 GPL17021

11 Samples

Download data: BIGWIG, TXT

(Submitter supplied) Cytotoxic T Lymphocytes (CTLs) are effector CD8+T cells that eradicate infected and malignant cells from organism. We analyze the role of the transcription factor NFATc1 in activation and cytotoxicity of murine CD8+ T lymphocytes

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL16417 GPL17021

9 Samples

Download data: TXT

(Submitter supplied) Cytotoxic T Lymphocytes (CTLs) are effector CD8+T cells that eradicate infected and malignant cells from organism. We analyze the role of the transcription factor NFATc1 in activation and cytotoxicity of murine CD8+ T lymphocytes

Organism:

Mus musculus

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL17021

2 Samples

Download data: BIGWIG

(Submitter supplied) The goal was to determine how IL-12 affects gene expression by murine CTL.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

4 Samples

Download data: CEL