GEO DataSets

Analysis of post-mortem hippocampus of chronic alcoholics (CAs). Chronic high-level alcohol consumption leads to decreased white matter and inhibition of neurogenesis. Results provide insight into molecular mechanisms that may play a role in the risk for alcoholism.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 disease state, 2 gender sets

Platform:

GPL6244

Series:

GSE44456

39 Samples

Download data: CEL

(Submitter supplied) Comparison of gene expression in post-mortem hippocampus from 20 alcoholics and 19 controls. The chronic high-level alcohol consumption seen in alcoholism leads to dramatic effects on the hippocampus, including decreased white matter, loss of oligodendrocytes and other glial cells, and inhibition of neurogenesis. Examining gene expression in post mortem hippocampal tissue from 20 alcoholics and 19 controls allowed us to detect differentially expressed genes that may play a role in the risk for alcoholism or whose expression is modified by chronic consumption of alcohol. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4879

Platform:

GPL6244

39 Samples

Download data: CEL

(Submitter supplied) 4 samples from 9 brain regions Brain tissue from the New South Wales Tissue Resource Centre, 9 brain regions, 4 samples each: 1 male alcoholic, 1 female alcoholic, 1 male control, 1 female control. Brain regions: pre-frontal cortex, cerebral cortex, visual cortex, thalamus, hippocampus, amygdala, caudate nucleus, putamen, cerebellum

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6244

36 Samples

Download data: CEL

(Submitter supplied) Compared gene expression in lymphoblasoid cell lines from alcholics and controls and 24 hr treatment with ethanol. To elucidate the effects of a controlled exposure to ethanol on gene expression, we studied lymphoblastoid cell lines (LCLs) from 21 alcoholics and 21 controls. We cultured each cell line for 24 h with and without 75 mM ethanol and measured gene expression using microarrays. Differences in expression between LCL from alcoholics and controls were modest, but included 13 genes previously identified as associated with alcoholism or related traits in one or more GWAS, including KCNA3, DICER1, ZNF415, Catalase and PPARGC1B. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS5430

Platform:

GPL570

84 Samples

Download data: CEL, CHP

Analysis of lymphoblastoid cell lines (LCLs), obtained from alcoholics, after treatment with ethanol in vitro. Results provide insight into the feasibility of using LCLs to study the molecular consequences of exposure to alcohol.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 agent, 2 disease state, 2 gender, 42 individual sets

Platform:

GPL570

Series:

GSE52553

84 Samples

Download data: CEL, CHP

(Submitter supplied) Genome wide DNA methylation profiling of depressed (n=324) and control subjects (n=209) that were recruited at the Max Planck Institute of Psychiatry (MPIP). The Illumina Infinium 450k Human DNA methylation Beadchip was used to obtain DNA methylation profiles based whole blood samples.

Organism:

Homo sapiens

Type:

Methylation profiling by array

Platform:

GPL13534

537 Samples

Download data: IDAT, TXT

(Submitter supplied) Childhood and cumulative exposure to trauma increases an individual's lifetime risk for psychiatric and stress-related disorders. This study evaluates DNA methylation in whole blood from African American participants, with the goal of identifying associaitons between peripheral DNA methylation and psychiatric symptoms.

Organism:

Homo sapiens

Type:

Methylation profiling by genome tiling array

Platform:

GPL13534

422 Samples

Download data: TXT

(Submitter supplied) The short term effects of alcohol on gene expression in brain tissue cannot directly be studied in humans. Because neuroimmune signaling is altered by alcohol, immune cells are a logical, accessible choice to study and might provide biomarkers. RNAseq was used to study the effects of 48 h exposure to ethanol on lymphoblastoid cell lines (LCLs) from 20 alcoholics and 20 controls. Ethanol exposure resulted in differential expression of 4,577 of the 12,526 genes detectably expressed in the LCLs (FDR ≤ 0.05); 55% of these showed increased expression. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL16558

80 Samples

Download data: TXT

(Submitter supplied) Chronic alcohol consumption can lead to alchohol-related brain damage (ARBD). Despite the well known acute effects of alcohol the mechanism responsible for chronic brain damage is largely unknown. Pathologically the major change is the loss of white matter while neuronal loss is mild and restricted to a few areas such as the prefrontal cortex. In order to improve our understanding of ARBD pathogenesis we used microarrays to explore the white matter transcriptome of alcoholics and controls. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL13667

32 Samples

Download data: CEL

(Submitter supplied) Analysis of transcriptiomic alternations related with alcohol use disorders (AUDs). The hypothesis is that chronic alcohol consumption might alter genome-wide gene expression patterns. The results suggest that differential gene expression in the prefrontal cortex is implicated in neuroadaptations to alcohol.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10904

48 Samples

Download data: TXT

(Submitter supplied) In this study, we investigated the prenatal effects of bisphenol-A (BPA) exposure on transcriptome profiles in the hippocampus of the rat offspring. Transcriptome profiling by RNA-seq analysis of hippocampi isolated from neonatal pups prenatally exposed to BPA was conducted and revealed a list of differentially expressed genes (DEGs) associated with ASD. Among the DEGs, several ASD candidate genes, including Auts2 and Foxp2, were dysregulated and showed sex differences in response to BPA exposure. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL22396

4 Samples

Download data: TXT