ds dachsous [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: dsprovided by FlyBase
Official Full Name: dachsousprovided by FlyBase
Primary source: FLYBASE:FBgn0284247
Locus tag: Dmel_CG17941
See related: AllianceGenome:FB:FBgn0284247
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: cad2; CG17941; CT39575; Dachsous; Dmel\CG17941; Ds; DS; EP-822; l(2)01855; l(2)05142
Summary: Enables cadherin binding activity and calcium ion binding activity. Involved in several processes, including calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; establishment of planar polarity; and regulation of hippo signaling. Located in apicolateral plasma membrane. Is expressed in several structures, including embryonic/larval head sense organ; epithelium; gut section; imaginal disc; and organism subdivision. Used to study obesity. Human ortholog(s) of this gene implicated in Van Maldergem syndrome 1 and mitral valve prolapse. Orthologous to several human genes including DCHS1 (dachsous cadherin-related 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 21E2-21E2; 2-1.5 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (640013..714983, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (640013..714983, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deciphering the roles of cell shape and Fat and Dachsous planar polarity in arranging the Drosophila apical microtubule network through quantitative image analysis.
Title: Deciphering the roles of cell shape and Fat and Dachsous planar polarity in arranging the Drosophila apical microtubule network through quantitative image analysis.
Heterophilic cell-cell adhesion of atypical cadherins Fat and Dachsous regulate epithelial cell size dynamics during Drosophila thorax morphogenesis.
Title: Heterophilic cell-cell adhesion of atypical cadherins Fat and Dachsous regulate epithelial cell size dynamics during Drosophila thorax morphogenesis.
Dlish (CG10933) tethers Dachs to the subapical cell cortex, an effect partly mediated by the palmitoyltransferase Approximated under the control of Fat. Conversely, Dlish promotes the Fat-mediated degradation of Dachs
Title: The novel SH3 domain protein Dlish/CG10933 mediates fat signaling in Drosophila by binding and regulating Dachs.
Ds imbalance within the migrating tissue provides the directional cue.
Title: Difference in Dachsous Levels between Migrating Cells Coordinates the Direction of Collective Cell Migration.
Cell Death Changes the Orientation of Cell Division in the Developing Drosophila Wing Imaginal Disc Without Using Fat or Dachsous as Orienting Signals
Title: Local Cell Death Changes the Orientation of Cell Division in the Developing Drosophila Wing Imaginal Disc Without Using Fat or Dachsous as Orienting Signals.
novel isoforms of dachsous genes expressed during development in Drosophila
Title: Transcriptional analysis of the dachsous gene uncovers novel isoforms expressed during development in Drosophila.
propose a mechanism by which the left-right asymmetry (LR) determinant Myosin ID (MyoID) transfers LR information to neighboring cells through the planar cell polarity atypical cadherin Dachsous
Title: The Atypical Cadherin Dachsous Controls Left-Right Asymmetry in Drosophila.
Fbxl7 binds to the Ft protein and regulates Dachs localization and Hippo signaling.
Title: The Drosophila F-box protein Fbxl7 binds to the protocadherin fat and regulates Dachs localization and Hippo signaling.
The gradient of Fj expression, phosphorylation of Ft by Fj and sub-cellular distal accumulation of Ds are three critical elements required for generating sub-cellular asymmetry of Ft-Ds heterodimer.
Title: Mathematical modeling of sub-cellular asymmetry of fat-dachsous heterodimer for generation of planar cell polarity.
Data proposes that Ft recruits FbxL7 to the proximal side of the cell to help restrict Ds and Dachs to the distal side of the cell.
Title: The ubiquitin ligase FbxL7 regulates the Dachsous-Fat-Dachs system in Drosophila.

Submit: New GeneRIF Correction See all GeneRIFs (34)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0344 (e-PCR)
- UniSTS:68246

Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: c695955-686974 mobile_element_type = transposon:roo{}281

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables cadherin binding	IPI Inferred from Physical Interaction more info	PubMed
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	IDA Inferred from Direct Assay more info	PubMed
involved_in cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell-cell adhesion mediated by cadherin	IDA Inferred from Direct Assay more info	PubMed
involved_in equator specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of cell polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of imaginal disc-derived wing hair orientation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of ommatidial planar polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of planar polarity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in establishment of planar polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IPI Inferred from Physical Interaction more info	PubMed
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IEA Inferred from Electronic Annotation more info
involved_in imaginal disc morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived leg morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule cytoskeleton organization involved in establishment of planar polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of hippo signaling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in ommatidial rotation	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of hippo signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization involved in establishment of planar polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of establishment of planar polarity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of establishment of planar polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of tube length, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wing disc pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in apicolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: dachsous

Names: CG17941-PA; CG17941-PB; cadherin-2; daschous; ds-PA; ds-PB; lethal (2) 01855

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

640013..714983 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_078722.3 → NP_523446.2 dachsous, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523446.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24292, Q9VPS4

UniProtKB/TrEMBL

X2J8E9

Related

FBpp0077708

Conserved Domains (2) summary

cd11304
Location:1158 → 1252

Cadherin_repeat; Cadherin tandem repeat domain

smart00112
Location:111 → 172

CA; Cadherin repeats
NM_001298622.1 → NP_001285551.1 dachsous, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001285551.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24292, Q9VPS4

UniProtKB/TrEMBL

X2J8E9

Conserved Domains (2) summary

cd11304
Location:1158 → 1252

Cadherin_repeat; Cadherin tandem repeat domain

smart00112
Location:111 → 172

CA; Cadherin repeats