wdr48b WD repeat domain 48b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: wdr48bprovided by ZNC
Official Full Name: WD repeat domain 48bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-6622
See related: Ensembl:ENSDARG00000038543 AllianceGenome:ZFIN:ZDB-GENE-030131-6622
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wd48; wdr48; fk50c12; zgc:66229; wu:fd19a04; wu:fk50c12
Summary: Predicted to enable DNA binding activity; deubiquitinase activator activity; and ubiquitin binding activity. Predicted to be involved in double-strand break repair via homologous recombination and positive regulation of double-strand break repair via homologous recombination. Predicted to act upstream of or within DNA repair. Predicted to be located in nucleus. Orthologous to human WDR48 (WD repeat domain 48). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 2

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (49805886..49834052)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (50071665..50099826)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fk50c12.x1 (e-PCR)
- UniSTS:201088

fd19a04.x1 (e-PCR)
- UniSTS:204234

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables deubiquitinase activator activity	ISS Inferred from Sequence or Structural Similarity more info
enables double-stranded DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables single-stranded DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables ubiquitin binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	IEA Inferred from Electronic Annotation more info
involved_in DNA damage response	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within DNA repair	IEA Inferred from Electronic Annotation more info
involved_in double-strand break repair via homologous recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of double-strand break repair via homologous recombination	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in late endosome	IEA Inferred from Electronic Annotation more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: WD repeat-containing protein 48

Names: USP1-associated factor 1; WD repeat domain 48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_214709.1 → NP_999874.1 WD repeat-containing protein 48

See identical proteins and their annotated locations for NP_999874.1

Status: PROVISIONAL

Source sequence(s)

BC057489

UniProtKB/Swiss-Prot

B0S5N8, Q6PFM9

Related

ENSDARP00000056247.4, ENSDART00000056248.5

Conserved Domains (4) summary

COG2319
Location:31 → 391

WD40; WD40 repeat [General function prediction only]

cd00200
Location:30 → 300

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam11816
Location:509 → 673

DUF3337; Domain of unknown function (DUF3337)

sd00039
Location:35 → 73

7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007113.7 Reference GRCz11 Primary Assembly

Range

49805886..49834052

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005168422.5 → XP_005168479.1 WD repeat-containing protein 48 isoform X1

UniProtKB/Swiss-Prot

B0S5N8, Q6PFM9

UniProtKB/TrEMBL

A0A8M2BFQ8

Conserved Domains (4) summary

COG2319
Location:31 → 390

WD40; WD40 repeat [General function prediction only]

cd00200
Location:30 → 299

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam11816
Location:508 → 672

DUF3337; Domain of unknown function (DUF3337)

sd00039
Location:35 → 72

7WD40; WD40 repeat [structural motif]
XM_005168423.5 → XP_005168480.1 WD repeat-containing protein 48 isoform X2

UniProtKB/Swiss-Prot

B0S5N8, Q6PFM9

UniProtKB/TrEMBL

A0A8M2BFR4

Conserved Domains (4) summary

COG2319
Location:27 → 325

WD40; WD40 repeat [General function prediction only]

cd00200
Location:28 → 298

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam11816
Location:507 → 671

DUF3337; Domain of unknown function (DUF3337)

sd00039
Location:33 → 71

7WD40; WD40 repeat [structural motif]