mxt mextli [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: mxtprovided by FlyBase
Official Full Name: mextliprovided by FlyBase
Primary source: FLYBASE:FBgn0031637
Locus tag: Dmel_CG2950
See related: AllianceGenome:FB:FBgn0031637
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BcDNA:GH06479; cg2950; CG2950; Dmel\CG2950; Mxt
Summary: Enables eukaryotic initiation factor 4E binding activity and translation initiation factor activity. Involved in female germ-line stem cell population maintenance; positive regulation of translation; and regulation of formation of translation initiation ternary complex. Located in cytoplasm. Part of RNA cap binding activity complex. Is expressed in several structures, including anterior-posterior subdivision of organism; follicle cell; and germline cell. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 25A8-25B1; 2-14 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (4841482..4847295, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (4841482..4847295, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Gene CG2950 encodes a 653-amino-acid protein with a molecular mass of 70.149 kDa. It is termed "Mextli"and it is a novel type of eIF4E-binding protein.
Title: Mextli is a novel eukaryotic translation initiation factor 4E-binding protein that promotes translation in Drosophila melanogaster.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables eukaryotic initiation factor 4E binding	IBA Inferred from Biological aspect of Ancestor more info
enables eukaryotic initiation factor 4E binding	IEA Inferred from Electronic Annotation more info
enables eukaryotic initiation factor 4E binding	IPI Inferred from Physical Interaction more info	PubMed
enables translation initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables translation initiation factor activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in female germ-line stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of translation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of translation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of formation of translation initiation ternary complex	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of formation of translation initiation ternary complex	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of RNA cap binding complex	IBA Inferred from Biological aspect of Ancestor more info
part_of RNA cap binding complex	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: mextli

Names: CG2950-PA; CG2950-PB; CG2950-PC; CG2950-PD; CG2950-PE; CG2950-PF; CG2950-PG; mxt-PA; mxt-PB; mxt-PC; mxt-PD; mxt-PE; mxt-PF; mxt-PG

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

4841482..4847295 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001273126.1 → NP_001260055.1 mextli, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260055.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PC59

Conserved Domains (1) summary

cd00105
Location:231 → 293

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
NM_135022.3 → NP_608866.1 mextli, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_608866.1

Status: REVIEWED

UniProtKB/Swiss-Prot

E1JHT5, Q9VR35

Related

FBpp0077101

Conserved Domains (1) summary

cd00105
Location:231 → 293

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
NM_001273125.1 → NP_001260054.1 mextli, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260054.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PCK5
NM_164598.2 → NP_723015.1 mextli, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_723015.1

Status: REVIEWED

UniProtKB/Swiss-Prot

E1JHT5, Q9VR35

Related

FBpp0077100

Conserved Domains (1) summary

cd00105
Location:231 → 293

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
NM_164599.2 → NP_723016.1 mextli, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_723016.1

Status: REVIEWED

UniProtKB/Swiss-Prot

E1JHT5, Q9VR35

Related

FBpp0077102

Conserved Domains (1) summary

cd00105
Location:231 → 293

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
NM_001273124.1 → NP_001260053.1 mextli, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260053.1

Status: REVIEWED

UniProtKB/Swiss-Prot

E1JHT5, Q9VR35

Conserved Domains (1) summary

cd00105
Location:231 → 293

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
NM_001169403.2 → NP_001162874.1 mextli, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001162874.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9VR35

Conserved Domains (1) summary

cd00105
Location:231 → 293

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...