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Cntln centlein, centrosomal protein [ Mus musculus (house mouse) ]

Gene ID: 338349, updated on 27-Nov-2024

Summary

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Official Symbol
Cntlnprovided by MGI
Official Full Name
centlein, centrosomal proteinprovided by MGI
Primary source
MGI:MGI:2443104
See related
Ensembl:ENSMUSG00000038070 AllianceGenome:MGI:2443104
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
B430108F07Rik; D530005L17Rik
Summary
Predicted to enable protein domain specific binding activity; protein kinase binding activity; and protein-macromolecule adaptor activity. Acts upstream of or within several processes, including regulation of protein localization; single fertilization; and spermatogenesis. Is active in sperm head-tail coupling apparatus. Orthologous to human CNTLN (centlein). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in CNS E11.5 (RPKM 3.3), limb E14.5 (RPKM 2.9) and 22 other tissues See more
Orthologs
human all
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Genomic context

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See Cntln in Genome Data Viewer
Location:
4 C4; 4 40.2 cM
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (84800024..85050160)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (84881787..85131923)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene 12415 Neighboring gene STARR-seq mESC enhancer starr_10670 Neighboring gene STARR-seq mESC enhancer starr_10671 Neighboring gene predicted gene, 27579 Neighboring gene STARR-seq mESC enhancer starr_10672 Neighboring gene STARR-seq mESC enhancer starr_10673 Neighboring gene dimethyladenosine transferase pseudogene Neighboring gene predicted gene 12419 Neighboring gene STARR-seq mESC enhancer starr_10675 Neighboring gene STARR-seq mESC enhancer starr_10676 Neighboring gene RAN, member RAS oncogene family pseudogene Neighboring gene SH3-domain GRB2-like 2 Neighboring gene phosphoglycerate mutase 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Centlein, a novel microtubule-associated protein stabilizing microtubules and involved in neurite formation. Jing Z, et al. Biochem Biophys Res Commun, 2016 Apr 1. PMID 26915804
  2. The missing linker between SUN5 and PMFBP1 in sperm head-tail coupling apparatus. Zhang Y, et al. Nat Commun, 2021 Aug 13. PMID 34389728, Free PMC Article
  3. Identification and characterization of the novel centrosomal protein centlein. Makino K, et al. Biochem Biophys Res Commun, 2008 Feb 22. PMID 18086554
  4. A direct interaction between CENTLEIN and RABIN8 is required for primary cilium formation. Li L, et al. Acta Biochim Biophys Sin (Shanghai), 2023 Jul 20. PMID 37475549, Free PMC Article
  5. A global genomic transcriptional code associated with CNS-expressed genes. Bailey PJ, et al. Exp Cell Res, 2006 Oct 1. PMID 16919269

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A direct interaction between CENTLEIN and RABIN8 is required for primary cilium formation.
    Title: A direct interaction between CENTLEIN and RABIN8 is required for primary cilium formation.
  2. Taken together, we propose that centlein is involved in MT stability and neuritogenesis in vivo.
    Title: Centlein, a novel microtubule-associated protein stabilizing microtubules and involved in neurite formation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein domain specific binding IEA
Inferred from Electronic Annotation
more info
  
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-macromolecule adaptor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-macromolecule adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in centriole-centriole cohesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in centriole-centriole cohesion IEA
Inferred from Electronic Annotation
more info
  
involved_in centriole-centriole cohesion ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to organelle IEA
Inferred from Electronic Annotation
more info
  
involved_in protein localization to organelle ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein-containing complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within single fertilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in centriole IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centriole IEA
Inferred from Electronic Annotation
more info
  
located_in centriole ISO
Inferred from Sequence Orthology
more info
  
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in sperm head-tail coupling apparatus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
centlein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001405430.1 → NP_001392359.1  centlein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL805906, AL806524, BX470174
    UniProtKB/Swiss-Prot
    A0PJC6, A2AM05, Q3TNP8, Q5EBN8, Q8C748, Q8C9U3, Q8CD25, Q8CE32, Q8R2F0, Q8R2P3
    Related
    ENSMUSP00000044138.7, ENSMUST00000047023.13

  2. NM_001405431.1 → NP_001392360.1  centlein isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL805906, BX470174

  3. NM_175275.5 → NP_780484.2  centlein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL805906, AL806524, BX470174
    Consensus CDS
    CCDS51216.1
    UniProtKB/Swiss-Prot
    A2AM05
    Related
    ENSMUSP00000130491.3, ENSMUST00000169371.9
    Conserved Domains (1) summary
    TIGR02168
    Location:523 → 1297
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  4. NM_177385.5 → NP_796359.1  centlein isoform 2

    See identical proteins and their annotated locations for NP_796359.1

    Status: VALIDATED

    Source sequence(s)
    AL805906, BX470174
    Consensus CDS
    CCDS18302.1
    UniProtKB/Swiss-Prot
    A2AM05
    Related
    ENSMUSP00000099883.4, ENSMUST00000102819.10
    Conserved Domains (1) summary
    pfam08537
    Location:155 → 248
    NBP1; Fungal Nap binding protein NBP1

RNA

  1. NR_175938.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL805906, AL806524, BX470174

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    84800024..85050160
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006538028.5 → XP_006538091.1  centlein isoform X4

    Conserved Domains (1) summary
    COG1196
    Location:130 → 774
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  2. XM_006538027.4 → XP_006538090.1  centlein isoform X2

    Conserved Domains (2) summary
    COG1196
    Location:24 → 622
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:369 → 1144
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  3. XM_036164203.1 → XP_036020096.1  centlein isoform X5

    Conserved Domains (1) summary
    TIGR02168
    Location:66 → 841
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  4. XM_006538029.4 → XP_006538092.1  centlein isoform X5

    Conserved Domains (1) summary
    TIGR02168
    Location:66 → 841
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  5. XM_011250056.4 → XP_011248358.1  centlein isoform X6

    Conserved Domains (2) summary
    COG1196
    Location:1 → 707
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:407 → 738
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  6. XM_036164204.1 → XP_036020097.1  centlein isoform X7

    Conserved Domains (2) summary
    COG1196
    Location:52 → 700
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:394 → 725
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

RNA

  1. XR_004941927.1 RNA Sequence

  2. XR_881069.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2AM05.1 GenPept UniProtKB/Swiss-Prot:A2AM05

Gene LinkOut

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