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coro Coronin [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35596, updated on 9-Dec-2024

Summary

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Official Symbol
coroprovided by FlyBase
Official Full Name
Coroninprovided by FlyBase
Primary source
FLYBASE:FBgn0265935
Locus tag
Dmel_CG9446
See related
AllianceGenome:FB:FBgn0265935
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG9446; Dmel\CG9446; l(2)k08011
Summary
Predicted to enable actin filament binding activity. Involved in adult somatic muscle development and defense response to fungus. Is expressed in several structures, including adult head; adult heart; anterior endoderm anlage; dorsal pharyngeal muscle cell; and mesoderm. Human ortholog(s) of this gene implicated in coronin-1A deficiency. Orthologous to several human genes including CORO1A (coronin 1A); CORO1B (coronin 1B); and CORO1C (coronin 1C). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See coro in Genome Data Viewer
Location:
42D6-42D6; 2-55 cM
Exon count:
11
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (6862001..6872718, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (2749506..2760223, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44166 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44169 Neighboring gene uncharacterized protein Neighboring gene Serpin 42Da

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Coronin-1 promotes directional cell rearrangement in Drosophila wing epithelium. Ikawa K, et al. Cell Struct Funct, 2023 Dec 20. PMID 38030242, Free PMC Article
  2. Sponge/DOCK-dependent regulation of F-actin networks directing cortical cap behaviors and syncytial furrow ingression. Henry SM, et al. Dev Biol, 2022 Nov. PMID 36067836
  3. Dissecting the complexity of CNV pathogenicity: insights from Drosophila and zebrafish models. Yusuff T, et al. Curr Opin Genet Dev, 2021 Jun. PMID 33812298, Free PMC Article
  4. Combinatorial deployment of F-actin regulators to build complex 3D actin structures in vivo. Xie Y, et al. Elife, 2021 May 5. PMID 33949307, Free PMC Article
  5. Genetic characterization of the Drosophila homologue of coronin. Bharathi V, et al. J Cell Sci, 2004 Apr 15. PMID 15090595

See all (60) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adult somatic muscle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in defense response to fungus IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
coronin
Names
CG9446-PA
CG9446-PB
CG9446-PC
CG9446-PD
CG9446-PE
CG9446-PF
CG9446-PG
coro-PA
coro-PB
coro-PC
coro-PD
coro-PE
coro-PF
coro-PG
lethal (2) k08011

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    6862001..6872718 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136398.4 → NP_610242.1  coronin, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610242.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JVY0
    Related
    FBpp0085526
    Conserved Domains (5) summary
    PTZ00421
    Location:9 → 485
    PTZ00421; coronin; Provisional
    pfam08953
    Location:7 → 64
    DUF1899; Domain of unknown function (DUF1899)
    pfam16300
    Location:343 → 385
    WD40_4; Type of WD40 repeat
    sd00039
    Location:37 → 78
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:79 → 294
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. NM_001273816.1 → NP_001260745.1  coronin, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260745.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KEJ7
    Conserved Domains (4) summary
    pfam08953
    Location:7 → 64
    DUF1899; Domain of unknown function (DUF1899)
    pfam16300
    Location:343 → 385
    WD40_4; Type of WD40 repeat
    sd00039
    Location:37 → 78
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:79 → 294
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  3. NM_001273815.1 → NP_001260744.1  coronin, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260744.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KEJ7
    Conserved Domains (4) summary
    pfam08953
    Location:7 → 64
    DUF1899; Domain of unknown function (DUF1899)
    pfam16300
    Location:343 → 385
    WD40_4; Type of WD40 repeat
    sd00039
    Location:37 → 78
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:79 → 294
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  4. NM_165494.2 → NP_724509.1  coronin, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724509.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JVY0
    Related
    FBpp0085527
    Conserved Domains (5) summary
    PTZ00421
    Location:9 → 485
    PTZ00421; coronin; Provisional
    pfam08953
    Location:7 → 64
    DUF1899; Domain of unknown function (DUF1899)
    pfam16300
    Location:343 → 385
    WD40_4; Type of WD40 repeat
    sd00039
    Location:37 → 78
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:79 → 294
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  5. NM_206031.2 → NP_995753.1  coronin, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995753.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JVY0
    Conserved Domains (5) summary
    PTZ00421
    Location:9 → 485
    PTZ00421; coronin; Provisional
    pfam08953
    Location:7 → 64
    DUF1899; Domain of unknown function (DUF1899)
    pfam16300
    Location:343 → 385
    WD40_4; Type of WD40 repeat
    sd00039
    Location:37 → 78
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:79 → 294
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  6. NM_001273813.1 → NP_001260742.1  coronin, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260742.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KEU5
    Conserved Domains (5) summary
    PTZ00421
    Location:9 → 491
    PTZ00421; coronin; Provisional
    pfam08953
    Location:7 → 64
    DUF1899; Domain of unknown function (DUF1899)
    pfam16300
    Location:349 → 391
    WD40_4; Type of WD40 repeat
    sd00039
    Location:37 → 85
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:85 → 300
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  7. NM_001273814.1 → NP_001260743.1  coronin, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260743.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KEJ7
    Conserved Domains (4) summary
    pfam08953
    Location:7 → 64
    DUF1899; Domain of unknown function (DUF1899)
    pfam16300
    Location:343 → 385
    WD40_4; Type of WD40 repeat
    sd00039
    Location:37 → 78
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:79 → 294
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KEJ7 A0A0B4KEJ7
A0A0B4KEU5 A0A0B4KEU5
Q7JVY0 Q7JVY0

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