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St6galnac6 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 407765, updated on 27-Nov-2024

Summary

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Official Symbol
St6galnac6provided by RGD
Official Full Name
ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6provided by RGD
Primary source
RGD:1303196
See related
EnsemblRapid:ENSRNOG00000046984 AllianceGenome:RGD:1303196
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Siat7F
Summary
Predicted to enable alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity. Predicted to be involved in ceramide metabolic process; glycoprotein metabolic process; and oligosaccharide biosynthetic process. Predicted to be located in cytoplasm. Orthologous to human ST6GALNAC6 (ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 118.8), Muscle (RPKM 92.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See St6galnac6 in Genome Data Viewer
Location:
3p11
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (36283573..36305217)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (15894275..15907502)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (11620050..11641460)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol-4-phosphate 5-kinase-like 1 Neighboring gene ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 Neighboring gene adenylate kinase 1 Neighboring gene endoglin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification and expression of a sialyltransferase responsible for the synthesis of disialylgalactosylgloboside in normal and malignant kidney cells: downregulation of ST6GalNAc VI in renal cancers. Senda M, et al. Biochem J, 2007 Mar 15. PMID 17123352, Free PMC Article
  2. Molecular cloning and expression of mouse GD1alpha/GT1aalpha/GQ1balpha synthase (ST6GalNAc VI) gene. Okajima T, et al. J Biol Chem, 2000 Mar 10. PMID 10702226
  3. Synthesis of disialyl Lewis a (Le(a)) structure in colon cancer cell lines by a sialyltransferase, ST6GalNAc VI, responsible for the synthesis of alpha-series gangliosides. Tsuchida A, et al. J Biol Chem, 2003 Jun 20. PMID 12668675
  4. The animal sialyltransferases and sialyltransferase-related genes: a phylogenetic approach. Harduin-Lepers A, et al. Glycobiology, 2005 Aug. PMID 15843597
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC109387

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables sialyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in ganglioside biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within ganglioside biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glycoprotein metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glycosphingolipid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glycosylceramide metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in oligosaccharide biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in oligosaccharide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
Names
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
ST6 GalNAc alpha-2,6-sialyltransferase 6
alpha-2,6-sialyltransferase ST6GalNAc VI
sialyltransferase 7F
NP_001385873.1
XP_038961570.1
XP_063140387.1
XP_063140388.1
XP_063140389.1
XP_063140390.1
XP_063140391.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001398944.1 → NP_001385873.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A6JU71, M0R3S4
    Conserved Domains (1) summary
    pfam00777
    Location:102 → 287
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    36283573..36305217
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063284319.1 → XP_063140389.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 isoform X3

    Related
    ENSRNOP00000088563.1, ENSRNOT00000094850.2

  2. XM_063284318.1 → XP_063140388.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 isoform X2

  3. XM_039105642.2 → XP_038961570.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 isoform X5

    Conserved Domains (1) summary
    pfam00777
    Location:1 → 133
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  4. XM_063284317.1 → XP_063140387.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 isoform X1

    Related
    ENSRNOP00000108263.1, ENSRNOT00000158168.1

  5. XM_063284321.1 → XP_063140391.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 isoform X6

    UniProtKB/TrEMBL
    Q5BJS3

  6. XM_063284320.1 → XP_063140390.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 isoform X4

    UniProtKB/TrEMBL
    Q6ZXY0
    Related
    ENSRNOP00000063995.4, ENSRNOT00000074401.4

RNA

  1. XR_005501955.2 RNA Sequence

  2. XR_005501954.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001015036.1: Suppressed sequence

    Description
    NM_001015036.1: This RefSeq was removed because currently there is insufficient support for the transcript.
Nucleotide Protein Strain
Heading Accession and Version

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