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hyd hyperplastic discs [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41181, updated on 9-Dec-2024

Summary

Official Symbol
hydprovided by FlyBase
Official Full Name
hyperplastic discsprovided by FlyBase
Primary source
FLYBASE:FBgn0002431
Locus tag
Dmel_CG9484
See related
AllianceGenome:FB:FBgn0002431
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
c43; CG9484; Dmel\CG9484; Hyd; HYD; l(3)85Ea; l(3)c43; l(3)C43; l(3)C43-3; l(3)SG33; l[[3]]c43; NP_524296.2; UBE 3A; Ubr5; UBR5
Summary
Enables ubiquitin protein ligase activity. Involved in several processes, including imaginal disc growth; male meiosis cytokinesis; and positive regulation of signal transduction. Located in cytoplasm and nucleus. Is expressed in organism. Human ortholog(s) of this gene implicated in breast cancer (multiple) and carcinoma (multiple). Orthologous to human UBR5 (ubiquitin protein ligase E3 component n-recognin 5). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See hyd in Genome Data Viewer
Location:
85E5-85E5; 3-49 cM
Exon count:
19
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9714623..9725615, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5540345..5551337, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene trabid Neighboring gene small Cajal body-specific RNA : PsiU1-6 Neighboring gene dalmatian Neighboring gene Forkhead box P Neighboring gene alpha-Tubulin at 85E

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding  
enables ubiquitin binding  
enables ubiquitin protein ligase activity PubMed 
enables ubiquitin protein ligase activity  
enables ubiquitin-protein transferase activity  
enables ubiquitin-ubiquitin ligase activity  
enables ubiquitin-ubiquitin ligase activity PubMed 
enables zinc ion binding  
Process Evidence Code Pubs
involved_in eye-antennal disc morphogenesis PubMed 
involved_in female gonad development PubMed 
involved_in imaginal disc development PubMed 
involved_in imaginal disc growth PubMed 
involved_in male meiosis cytokinesis PubMed 
involved_in positive regulation of canonical Wnt signaling pathway  
involved_in positive regulation of canonical Wnt signaling pathway PubMed 
involved_in positive regulation of peptidoglycan recognition protein signaling pathway PubMed 
involved_in protein K48-linked ubiquitination  
involved_in protein K63-linked ubiquitination PubMed 
involved_in protein polyubiquitination  
involved_in protein polyubiquitination PubMed 
involved_in spermatid nucleus differentiation PubMed 
involved_in spermatogenesis PubMed 
involved_in wing disc development PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm  
located_in cytoplasm PubMed 
is_active_in nucleus  
located_in nucleus PubMed 

General protein information

Preferred Names
hyperplastic discs
Names
CG9484-PA
CG9484-PB
hyd-PA
hyd-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    9714623..9725615 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079572.4 → NP_524296.2  hyperplastic discs, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524296.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P51592, Q9VH88
    UniProtKB/TrEMBL
    A0A0H4Y1G5
    Related
    FBpp0081568
    Conserved Domains (5) summary
    smart00396
    Location:1217 → 1284
    ZnF_UBR1; Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway
    smart00517
    Location:2496 → 2559
    PolyA; C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein
    smart00119
    Location:2587 → 2882
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    pfam11547
    Location:150 → 196
    E3_UbLigase_EDD; E3 ubiquitin ligase EDD
    NF033845
    Location:1570 → 1742
    MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
  2. NM_001300333.1 → NP_001287262.1  hyperplastic discs, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287262.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LGZ6
    Conserved Domains (6) summary
    smart00396
    Location:1217 → 1284
    ZnF_UBR1; Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway
    smart00517
    Location:2498 → 2561
    PolyA; C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein
    smart00119
    Location:2589 → 2884
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:2589 → 2885
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam11547
    Location:150 → 196
    E3_UbLigase_EDD; E3 ubiquitin ligase EDD
    cl22451
    Location:1535 → 1733
    ASF1_hist_chap; ASF1 like histone chaperone
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