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FKGP L-fucokinase/GDP-L-fucose pyrophosphorylase [ Arabidopsis thaliana (thale cress) ]

Gene ID: 839420, updated on 18-Sep-2024

Summary

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Official Symbol
FKGP
Official Full Name
L-fucokinase/GDP-L-fucose pyrophosphorylase
Primary source
TAIR:AT1G01220
Locus tag
AT1G01220
See related
Araport:AT1G01220
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
Arabidopsis thaliana L-fucokinase/GDP-L-fucose pyrophosphorylase; AtFKGP; F6F3.3; F6F3_3; L-fucokinase/GDP-L-fucose pyrophosphorylase
Summary
Encodes a bifunctional enzyme that has both L-fucokinase and GDP-L-fucose pyrophosphorylase activities. It catalyzes the two steps of the L-fucose salvage pathway for the generation of activated GDP-L-fucose. This pathway seems to be of minor importance for cell wall polysaccharide biosynthesis compared to the de novo GDP-L-fucose biosynthesis pathway in Arabidopsis.
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Genomic context

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See FKGP in Genome Data Viewer
Location:
chromosome: 1
Exon count:
7
Sequence:
Chromosome: 1; NC_003070.9 (91342..95681)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene RAB GTPase homolog A3 Neighboring gene DNA-directed RNA polymerase, subunit M, archaeal Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene NC domain-containing protein-like protein Neighboring gene ORMDL family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A bifunctional enzyme with L-fucokinase and GDP-L-fucose pyrophosphorylase activities salvages free L-fucose in Arabidopsis. Kotake T, et al. J Biol Chem, 2008 Mar 28. PMID 18199744
  2. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. AtFKGP is a bifunctional enzyme with L-fucokinase and GDP-L-Fuc pyrophosphorylase activities, which salvages free L-Fuc in Arabidopsis
    Title: A bifunctional enzyme with L-fucokinase and GDP-L-fucose pyrophosphorylase activities salvages free L-fucose in Arabidopsis.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

NM_001331259.1
NM_001331260.1
NM_001331261.1
NM_001331262.1
NM_100004.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables fucokinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables fucose-1-phosphate guanylyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within GDP-L-fucose salvage IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
L-fucokinase/GDP-L-fucose pyrophosphorylase
NP_563620.1
  • L-fucokinase/GDP-L-fucose pyrophosphorylase (FKGP); FUNCTIONS IN: fucose-1-phosphate guanylyltransferase activity, fucokinase activity, ATP binding, galactokinase activity; INVOLVED IN: GDP-L-fucose salvage; LOCATED IN: cytoplasm; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Mevalonate/galactokinase (InterPro:IPR006206), Ribosomal protein S5 domain 2-type fold (InterPro:IPR020568), GHMP kinase (InterPro:IPR006204), L-fucokinase (InterPro:IPR012887), Ribosomal protein S5 domain 2-type fold, subgroup (InterPro:IPR014721), GHMP kinase, C-terminal (InterPro:IPR013750); Has 1878 Blast hits to 1819 proteins in 539 species: Archae - 59; Bacteria - 918; Metazoa - 155; Fungi - 3; Plants - 87; Viruses - 3; Other Eukaryotes - 653 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    91342..95681
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001331256.1 → NP_001320981.1  L-fucokinase/GDP-L-fucose pyrophosphorylase [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8APH1, A0A7G2DTB6

  2. NM_001331257.1 → NP_001320980.1  L-fucokinase/GDP-L-fucose pyrophosphorylase [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8API3, A0A654E739

  3. NM_001331258.1 → NP_001320985.1  L-fucokinase/GDP-L-fucose pyrophosphorylase [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178W6Y3, A0A1P8APH6, A0A384LK65, A0A654E739
    Conserved Domains (2) summary
    PRK13412
    Location:19 → 935
    fkp; bifunctional fucokinase/L-fucose-1-P-guanylyltransferase; Provisional
    pfam07959
    Location:24 → 422
    Fucokinase; L-fucokinase

  4. NM_100004.4 → NP_563620.1  L-fucokinase/GDP-L-fucose pyrophosphorylase [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_563620.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9LNJ9
    UniProtKB/TrEMBL
    A0A5S9S1M5, A0A654E739
    Conserved Domains (2) summary
    PRK13412
    Location:32 → 1042
    fkp; bifunctional fucokinase/L-fucose-1-P-guanylyltransferase; Provisional
    pfam07959
    Location:131 → 529
    Fucokinase; L-fucokinase

  5. NM_001331259.1 → NP_001320984.1  L-fucokinase/GDP-L-fucose pyrophosphorylase [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8APH1, A0A7G2DTB6

  6. NM_001331260.1 → NP_001320983.1  L-fucokinase/GDP-L-fucose pyrophosphorylase [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8APH1, A0A7G2DTB6

  7. NM_001331261.1 → NP_001320982.1  L-fucokinase/GDP-L-fucose pyrophosphorylase [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9LNJ9
    UniProtKB/TrEMBL
    A0A5S9S1M5, A0A654E739
    Conserved Domains (2) summary
    PRK13412
    Location:32 → 1042
    fkp; bifunctional fucokinase/L-fucose-1-P-guanylyltransferase; Provisional
    pfam07959
    Location:131 → 529
    Fucokinase; L-fucokinase

  8. NM_001331262.1 → NP_001320979.1  L-fucokinase/GDP-L-fucose pyrophosphorylase [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8API3, A0A654E739
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9LNJ9.2

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