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PSF1 DNA replication protein PSF1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851576, updated on 9-Dec-2024

Summary

Official Symbol
PSF1
Official Full Name
DNA replication protein PSF1
Primary source
SGD:S000002420
Locus tag
YDR013W
See related
AllianceGenome:SGD:S000002420; FungiDB:YDR013W; VEuPathDB:YDR013W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CDC101
Summary
Involved in DNA-templated DNA replication and double-strand break repair via break-induced replication. Part of CMG complex; GINS complex; and replication fork protection complex. Human ortholog(s) of this gene implicated in immunodeficiency 55. Orthologous to human GINS1 (GINS complex subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

See PSF1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (473157..473783)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene ATP-binding cassette transporter SNQ2 Neighboring gene ribosomal 60S subunit protein L4B Neighboring gene Rad61p Neighboring gene Hed1p

Bibliography

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by SGD

Component Evidence Code Pubs
part_of CMG complex PubMed 
part_of DNA replication preinitiation complex PubMed 
part_of DNA replication preinitiation complex PubMed 
part_of GINS complex  
part_of GINS complex  
part_of GINS complex PubMed 
located_in nucleus  
part_of replication fork protection complex PubMed 

General protein information

Preferred Names
DNA replication protein PSF1
NP_010296.3
  • Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p); complex is localized to DNA replication origins and implicated in assembly of the DNA replication machinery

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    473157..473783
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180321.3 → NP_010296.3  TPA: DNA replication protein PSF1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010296.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VRZ9, Q12488
    UniProtKB/TrEMBL
    A6ZXX8, B3LGP8, B5VFS1, C7GLY3, C8Z4T2, G2WAC0, N1P7Y6
    Conserved Domains (1) summary
    COG5230
    Location:1 → 208
    COG5230; Uncharacterized conserved protein [Function unknown]
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