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GCD2 translation initiation factor eIF2B subunit delta [ Saccharomyces cerevisiae S288C ]

Gene ID: 852974, updated on 9-Dec-2024

Summary

Official Symbol
GCD2
Official Full Name
translation initiation factor eIF2B subunit delta
Primary source
SGD:S000003315
Locus tag
YGR083C
See related
AllianceGenome:SGD:S000003315; FungiDB:YGR083C; VEuPathDB:YGR083C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
GCD12
Summary
Enables enzyme regulator activity and translation initiation factor activity. Contributes to guanyl-nucleotide exchange factor activity. Involved in regulation of translational initiation. Located in cytosol. Part of eukaryotic translation initiation factor 2B complex and guanyl-nucleotide exchange factor complex. Used to study leukoencephalopathy with vanishing white matter. Human ortholog(s) of this gene implicated in leukoencephalopathy with vanishing white matter and leukoencephalopathy with vanishing white matter 4. Orthologous to human EIF2B4 (eukaryotic translation initiation factor 2B subunit delta). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

See GCD2 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (644860..646815, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Slx9p Neighboring gene Tom20p Neighboring gene mitochondrial 37S ribosomal protein YmS-A Neighboring gene ribosomal 60S subunit protein L11B

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by SGD

General protein information

Preferred Names
translation initiation factor eIF2B subunit delta
NP_011597.1
  • Delta subunit of the translation initiation factor eIF2B; the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    644860..646815 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181212.1 → NP_011597.1  TPA: translation initiation factor eIF2B subunit delta [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011597.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VUL5, P12754
    UniProtKB/TrEMBL
    B3LIE3, B5VJ27, C8Z8X7, N1P3Y3
    Conserved Domains (2) summary
    PHA03255
    Location:120 → 232
    PHA03255; BDLF3; Provisional
    pfam01008
    Location:285 → 637
    IF-2B; Initiation factor 2 subunit family
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