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putative alanine--tRNA ligase [ Saccharomyces cerevisiae S288C ]

Gene ID: 855688, updated on 17-Dec-2024

Summary

Official Full Name
putative alanine--tRNA ligase
Primary source
SGD:S000004985
Locus tag
YNL040W
See related
AllianceGenome:SGD:S000004985; FungiDB:YNL040W; VEuPathDB:YNL040W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables L-seryl-tRNA(Thr) hydrolase activity and Ser-tRNA(Ala) hydrolase activity. Involved in aminoacyl-tRNA metabolism involved in translational fidelity. Located in cytoplasm. Orthologous to human PTGES3L-AARSD1 (PTGES3L-AARSD1 readthrough) and AARSD1 (alanyl-tRNA synthetase domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (553380..554750)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Golgi transport complex subunit COG6 Neighboring gene uncharacterized protein Neighboring gene transcription factor TFIIIB subunit BDP1 Neighboring gene phosphatidylinositol N-acetylglucosaminyltransferase GPI15

Interactions

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding  
enables L-seryl-tRNA(Thr) hydrolase activity PubMed 
enables Ser-tRNA(Ala) hydrolase activity  
enables Ser-tRNA(Ala) hydrolase activity PubMed 
enables aminoacyl-tRNA ligase activity  
enables metal ion binding  
enables zinc ion binding PubMed 
Component Evidence Code Pubs
located_in cytoplasm PubMed 

General protein information

Preferred Names
putative alanine--tRNA ligase
NP_014358.3
  • Ser-tRNA(Ala) hydrolase; hydrolyzes Ser-mischarged cytoplasmic and mitochondrial tRNAs; regulates translational fidelity based on Ala- and Thr-to-Ser misincorporation in the null mutant; trans-editing factor for alanyl- and threonyl-tRNA synthetases and seryl-tRNA synthetase (SerRS) via hydrolysis; null mutant displays decreased translation rate and increased readthrough of premature stop codons; (GFP)-fusion protein localizes to the cytoplasm; homologous to human trans-editing factor AARSD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    553380..554750
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182879.3 → NP_014358.3  TPA: putative alanine--tRNA ligase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014358.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W1D9, P53960
    UniProtKB/TrEMBL
    B5VQZ7, G2WM63, N1NZK3
    Conserved Domains (1) summary
    COG2872
    Location:11 → 281
    AlaX; Ser-tRNA(Ala) deacylase AlaX (editing enzyme) [Translation, ribosomal structure and biogenesis]
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