Golga2 golgin A2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Golga2provided by MGI
Official Full Name: golgin A2provided by MGI
Primary source: MGI:MGI:2139395
See related: Ensembl:ENSMUSG00000002546 AllianceGenome:MGI:2139395
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GM130
Summary: Enables importin-alpha family protein binding activity. Involved in asymmetric cell division and meiotic spindle assembly. Acts upstream of or within Golgi localization and positive regulation of axonogenesis. Located in Golgi apparatus; perinuclear region of cytoplasm; and spindle pole. Is expressed in several structures, including brain; eye; gonad; musculoskeletal system; and unsegmented mesenchyme. Orthologous to human GOLGA2 (golgin A2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in ovary adult (RPKM 20.8), limb E14.5 (RPKM 16.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 B; 2 22.09 cM

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (32178299..32197925)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (32288287..32307913)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cdk1 protects against oxygen-glucose deprivation and reperfusion-induced Golgi fragmentation and apoptosis through mediating GM130 phosphorylation.
Title: Cdk1 protects against oxygen-glucose deprivation and reperfusion-induced Golgi fragmentation and apoptosis through mediating GM130 phosphorylation.
WDR38, a novel equatorial segment protein, interacts with the GTPase protein RAB19 and Golgi protein GM130 to play roles in acrosome biogenesis.
Title: WDR38, a novel equatorial segment protein, interacts with the GTPase protein RAB19 and Golgi protein GM130 to play roles in acrosome biogenesis.
Loss of GM130 does not impair oocyte meiosis and embryo development in mice.
Title: Loss of GM130 does not impair oocyte meiosis and embryo development in mice.
knockdown of GM130 (also known as GOLGA2) or p115 (also known as USO1), two regulators of the early secretory pathway, impairs GC and ERES reorganisation. This in turn results in inhibition of myotube fusion and M-cadherin (also known as CDH15) transport to the sarcolemma.
Title: GM130 and p115 play a key role in the organisation of the early secretory pathway during skeletal muscle differentiation.
Deletion of GM130 in neurons causes fragmentation.
Title: Loss of the golgin GM130 causes Golgi disruption, Purkinje neuron loss, and ataxia in mice.
Therefore, we confirmed the associations among Golgi function, fibrosis, and autophagy. Moreover, GOLGA2 knockout mice may be a potentially valuable animal model for studying autophagy-induced fibrosis.
Title: GOLGA2 loss causes fibrosis with autophagy in the mouse lung and liver.
the GM130-deficient mouse provides a valuable model for investigating the etiology of human globozoospermia.
Title: Globozoospermia and lack of acrosome formation in GM130-deficient mice.
In oocyte meiosis, GM130 localization and expression patterns are regulated by FMNL1.
Title: RhoA-mediated FMNL1 regulates GM130 for actin assembly and phosphorylates MAPK for spindle formation in mouse oocyte meiosis.
GM130 regulates microtubule organization and might cooperate with the MAPK pathway to play roles in spindle organization, migration and asymmetric division during mouse oocyte maturation
Title: GM130, a cis-Golgi protein, regulates meiotic spindle assembly and asymmetric division in mouse oocyte.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW555139 (e-PCR)
- UniSTS:178602

D2Mit121 (e-PCR), detects polymorphism
- UniSTS:128980

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables importin-alpha family protein binding	IDA Inferred from Direct Assay more info	PubMed
enables importin-alpha family protein binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables syntaxin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Golgi disassembly	ISO Inferred from Sequence Orthology more info
involved_in Golgi disassembly	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within Golgi localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Golgi organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in Golgi ribbon formation	ISO Inferred from Sequence Orthology more info
involved_in Golgi ribbon formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in asymmetric cell division	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in centrosome cycle	ISO Inferred from Sequence Orthology more info
involved_in centrosome cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	ISO Inferred from Sequence Orthology more info
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in meiotic spindle assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule nucleation	ISO Inferred from Sequence Orthology more info
involved_in microtubule nucleation	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitotic spindle assembly	ISO Inferred from Sequence Orthology more info
involved_in mitotic spindle assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of autophagy	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein binding	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein glycosylation	ISO Inferred from Sequence Orthology more info
involved_in protein glycosylation	ISO Inferred from Sequence Orthology more info
involved_in protein glycosylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein homotetramerization	ISO Inferred from Sequence Orthology more info
involved_in protein homotetramerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in spindle assembly	ISO Inferred from Sequence Orthology more info
involved_in spindle assembly	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in COPII-coated ER to Golgi transport vesicle	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info	PubMed
is_active_in Golgi cis cisterna	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi cis cisterna	ISO Inferred from Sequence Orthology more info
is_active_in Golgi cisterna membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi cisterna membrane	ISO Inferred from Sequence Orthology more info
located_in Golgi cisterna membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in Golgi membrane	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi membrane	TAS Traceable Author Statement more info
is_active_in cis-Golgi network	IBA Inferred from Biological aspect of Ancestor more info
located_in cis-Golgi network	IDA Inferred from Direct Assay more info	PubMed
located_in cis-Golgi network	ISO Inferred from Sequence Orthology more info	PubMed
located_in endoplasmic reticulum-Golgi intermediate compartment membrane	IEA Inferred from Electronic Annotation more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in mitotic spindle	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle	ISS Inferred from Sequence or Structural Similarity more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in spindle pole	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: golgin subfamily A member 2

Names: 130 kDa cis-Golgi matrix protein; SY11 protein; golgi autoantigen, golgin subfamily a, 2; golgin-95

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001080968.2 → NP_001074437.2 golgin subfamily A member 2 isoform b

Status: VALIDATED

Source sequence(s)

AL808027

Consensus CDS

CCDS38101.1

UniProtKB/Swiss-Prot

A2AN43, A2AN47, Q921M4

UniProtKB/TrEMBL

A0A6I8MWY5

Related

ENSMUSP00000159316.2, ENSMUST00000239447.2

Conserved Domains (2) summary

TIGR02168
Location:136 → 467

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam15070
Location:369 → 987

GOLGA2L5; Putative golgin subfamily A member 2-like protein 5
NM_001362695.2 → NP_001349624.2 golgin subfamily A member 2 isoform c

Status: VALIDATED

Source sequence(s)

AL808027

UniProtKB/TrEMBL

Q5DTL1

Conserved Domains (2) summary

COG1196
Location:194 → 541

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam15070
Location:369 → 987

GOLGA2L5; Putative golgin subfamily A member 2-like protein 5
NM_001362696.2 → NP_001349625.2 golgin subfamily A member 2 isoform d

Status: VALIDATED

Source sequence(s)

AL808027

UniProtKB/Swiss-Prot

A2AN43, A2AN47, Q921M4

Conserved Domains (2) summary

COG1196
Location:167 → 514

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam15070
Location:342 → 960

GOLGA2L5; Putative golgin subfamily A member 2-like protein 5
NM_001362697.2 → NP_001349626.2 golgin subfamily A member 2 isoform e

Status: VALIDATED

Source sequence(s)

AL808027

UniProtKB/Swiss-Prot

A2AN43, A2AN47, Q921M4

UniProtKB/TrEMBL

Z4YJU8

Related

ENSMUSP00000080374.9, ENSMUST00000081670.14

Conserved Domains (2) summary

TIGR02168
Location:104 → 435

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam15070
Location:337 → 955

GOLGA2L5; Putative golgin subfamily A member 2-like protein 5
NM_001362698.2 → NP_001349627.2 golgin subfamily A member 2 isoform f

Status: VALIDATED

Source sequence(s)

AL808027

UniProtKB/Swiss-Prot

A2AN43, A2AN47, Q921M4

Conserved Domains (2) summary

COG1196
Location:135 → 482

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam15070
Location:310 → 928

GOLGA2L5; Putative golgin subfamily A member 2-like protein 5
NM_133852.3 → NP_598613.3 golgin subfamily A member 2 isoform a

Status: VALIDATED

Source sequence(s)

AL808027

Consensus CDS

CCDS38100.1

UniProtKB/TrEMBL

E9PUQ5, Q5DTL1

Related

ENSMUSP00000097768.4, ENSMUST00000100194.10

Conserved Domains (2) summary

TIGR02168
Location:163 → 494

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam15070
Location:396 → 1014

GOLGA2L5; Putative golgin subfamily A member 2-like protein 5

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

32178299..32197925

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006498491.4 → XP_006498554.1 golgin subfamily A member 2 isoform X2

UniProtKB/TrEMBL

A0A6I8MX07

Conserved Domains (2) summary

COG1196
Location:193 → 540

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam15070
Location:368 → 986

GOLGA2L5; Putative golgin subfamily A member 2-like protein 5
XM_017319359.2 → XP_017174848.1 golgin subfamily A member 2 isoform X1

UniProtKB/Swiss-Prot

A2AN43, A2AN47, Q921M4

Conserved Domains (2) summary

TIGR02168
Location:143 → 474

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam15070
Location:376 → 994

GOLGA2L5; Putative golgin subfamily A member 2-like protein 5