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    Cox16 cytochrome c oxidase assembly protein 16 [ Mus musculus (house mouse) ]

    Gene ID: 66272, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cox16provided by MGI
    Official Full Name
    cytochrome c oxidase assembly protein 16provided by MGI
    Primary source
    MGI:MGI:1913522
    See related
    Ensembl:ENSMUSG00000091803 AllianceGenome:MGI:1913522
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1810020G14Rik; 1810055I05Rik
    Summary
    Predicted to be involved in mitochondrial cytochrome c oxidase assembly. Located in mitochondrion. Is expressed in genitourinary system; genitourinary system mesenchyme; mesonephros; mesonephros mesenchyme; and metanephric mesenchyme. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 22. Orthologous to human COX16 (cytochrome c oxidase assembly factor COX16). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E14 (RPKM 5.8), CNS E11.5 (RPKM 5.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cox16 in Genome Data Viewer
    Location:
    12 D1; 12 37.6 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (81405626..81531911, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (81358852..81485137, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 8 (sodium/calcium exchanger), member 3 Neighboring gene predicted gene 3693 Neighboring gene STARR-seq mESC enhancer starr_32669 Neighboring gene STARR-seq mESC enhancer starr_32670 Neighboring gene predicted gene, 53730 Neighboring gene synaptojanin 2 binding protein Cox16 readthrough Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene 4787 Neighboring gene heat shock protein 1 (chaperonin 10), pseudogene 2 Neighboring gene STARR-seq mESC enhancer starr_32671 Neighboring gene STARR-seq mESC enhancer starr_32672 Neighboring gene a disintegrin and metallopeptidase domain 4 Neighboring gene STARR-seq mESC enhancer starr_32673 Neighboring gene STARR-positive B cell enhancer ABC_E9388 Neighboring gene STARR-positive B cell enhancer ABC_E7157 Neighboring gene STARR-seq mESC enhancer starr_32674 Neighboring gene synaptojanin 2 binding protein Neighboring gene a disintegrin and metallopeptidase domain 21

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    2. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
    3. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 

    General gene information

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    Markers

    Readthrough S2bpcox16

    Readthrough gene: S2bpcox16, Included gene: Synj2bp

    Homology

    Clone Names

    • MGC118423

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial cytochrome c oxidase assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial cytochrome c oxidase assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial cytochrome c oxidase assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    cytochrome c oxidase assembly protein COX16 homolog, mitochondrial

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001309808.1 → NP_001296737.1  cytochrome c oxidase assembly protein COX16 homolog, mitochondrial isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' terminal exon and lacks a portion of the 3' coding region, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AA881507, AC132391, AK007450, AK082374, AK087666
      Consensus CDS
      CCDS83978.1
      UniProtKB/TrEMBL
      E9Q3U7, E9Q5H8
      Related
      ENSMUSP00000127295.2, ENSMUST00000168463.8
      Conserved Domains (1) summary
      pfam14138
      Location:16 → 68
      COX16; Cytochrome c oxidase assembly protein COX16

    2. NM_001309809.2 → NP_001296738.1  cytochrome c oxidase assembly protein COX16 homolog, mitochondrial isoform 3

      See identical proteins and their annotated locations for NP_001296738.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate 3' terminal exon, compared to variant 1. It encodes isoform 3 which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC132391, AK087666
      Consensus CDS
      CCDS83976.1
      UniProtKB/TrEMBL
      E9Q5H8, Q497I8
      Related
      ENSMUSP00000105969.3, ENSMUST00000110340.9
      Conserved Domains (1) summary
      pfam14138
      Location:16 → 70
      COX16; Cytochrome c oxidase assembly protein COX16

    3. NM_001309810.2 → NP_001296739.1  cytochrome c oxidase assembly protein COX16 homolog, mitochondrial isoform 4

      See identical proteins and their annotated locations for NP_001296739.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains two alternate exons, including an alternate 3' terminal exon, compared to variant 1. It encodes isoform 4 which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC132391, AK087666, BG078831
      Consensus CDS
      CCDS83977.1
      UniProtKB/TrEMBL
      E9Q5H8, G3UWC6
      Related
      ENSMUSP00000130935.2, ENSMUST00000166723.8
      Conserved Domains (1) summary
      pfam14138
      Location:16 → 68
      COX16; Cytochrome c oxidase assembly protein COX16

    4. NM_025461.6 → NP_079737.1  cytochrome c oxidase assembly protein COX16 homolog, mitochondrial isoform 1

      See identical proteins and their annotated locations for NP_079737.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC132391, AK007450, AK082374
      Consensus CDS
      CCDS26020.1
      UniProtKB/Swiss-Prot
      Q8BNX4, Q99J15, Q9CR63
      Related
      ENSMUSP00000002757.4, ENSMUST00000002757.11
      Conserved Domains (1) summary
      pfam14138
      Location:16 → 88
      COX16; Cytochrome c oxidase assembly protein COX16

    RNA

    1. NR_132134.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) contains an alternate first exon and uses an alternate splice site in the 3' terminal exon, compared to variant 1. This variant is represented as non-coding because it lacks an in-frame ORF.
      Source sequence(s)
      AC132391, AK007450, AK007870, AK082374

    2. NR_132135.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) contains an alternate first exon, compared to variant 1. This variant is represented as non-coding because it lacks an in-frame ORF.
      Source sequence(s)
      AC132391, AK007450, AK007870, AK082374

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      81405626..81531911 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CR63.1 GenPept UniProtKB/Swiss-Prot:Q9CR63

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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