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    hrpk-1 Heterogeneous nuclear ribonucleoprotein K homolog [ Caenorhabditis elegans ]

    Gene ID: 172330, updated on 9-Dec-2024

    Summary

    Official Symbol
    hrpk-1
    Official Full Name
    Heterogeneous nuclear ribonucleoprotein K homolog
    Primary source
    WormBase:WBGene00017816
    Locus tag
    CELE_F26B1.2
    See related
    AllianceGenome:WB:WBGene00017816
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable mRNA binding activity. Involved in DNA damage response and embryo development. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including germ line; hypodermal cell; intestinal cell; muscle cell; and oocyte. Human ortholog(s) of this gene implicated in Raynaud disease. Orthologous to human HNRNPK (heterogeneous nuclear ribonucleoprotein K). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See hrpk-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    8
    Sequence:
    Chromosome: I; NC_003279.8 (6317701..6320364)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Serpentine receptor class gamma-14 Neighboring gene Importin subunit alpha-2 Neighboring gene Forkhead box protein F Neighboring gene Uncharacterized protein Neighboring gene MS Related Protein

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding  
    enables mRNA binding  
    enables nucleic acid binding  
    enables protein binding PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytoplasm  
    is_active_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    Heterogeneous nuclear ribonucleoprotein K homolog
    NP_001379657.1
    • Confirmed by transcript evidence
    NP_001379658.1
    • Confirmed by transcript evidence
    NP_001379659.1
    • Confirmed by transcript evidence
    NP_001379660.1
    • Confirmed by transcript evidence
    NP_740869.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      6317701..6320364
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170880.6 → NP_740869.1  Heterogeneous nuclear ribonucleoprotein K homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_740869.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P91277, Q8I7G7, Q8I7G8, Q8I7G9, Q8T3B5
      Conserved Domains (3) summary
      cd22432
      Location:49 → 112
      KH-I_HNRNPK_rpt1; first type I K homology (KH) RNA-binding domain found in heterogeneous nuclear ribonucleoprotein K (hnRNP K) and similar proteins
      cd22433
      Location:124 → 193
      KH-I_HNRNPK_rpt2; second type I K homology (KH) RNA-binding domain found in heterogeneous nuclear ribonucleoprotein K (hnRNP K) and similar proteins
      cd22434
      Location:316 → 388
      KH-I_HNRNPK_rpt3; third type I K homology (KH) RNA-binding domain found in heterogeneous nuclear ribonucleoprotein K (hnRNP K) and similar proteins
    2. NM_001392429.1 → NP_001379660.1  Heterogeneous nuclear ribonucleoprotein K homolog [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      cd22432
      Location:49 → 93
      KH-I_HNRNPK_rpt1; first type I K homology (KH) RNA-binding domain found in heterogeneous nuclear ribonucleoprotein K (hnRNP K) and similar proteins
    3. NM_001392432.1 → NP_001379657.1  Heterogeneous nuclear ribonucleoprotein K homolog [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      cl00098
      Location:32 → 61
      KH-I; K homology (KH) RNA-binding domain, type I
    4. NM_001392433.1 → NP_001379659.1  Heterogeneous nuclear ribonucleoprotein K homolog [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      cl00098
      Location:32 → 61
      KH-I; K homology (KH) RNA-binding domain, type I
    5. NM_001392431.1 → NP_001379658.1  Heterogeneous nuclear ribonucleoprotein K homolog [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (3) summary
      cd22432
      Location:32 → 95
      KH-I_HNRNPK_rpt1; first type I K homology (KH) RNA-binding domain found in heterogeneous nuclear ribonucleoprotein K (hnRNP K) and similar proteins
      cd22433
      Location:107 → 176
      KH-I_HNRNPK_rpt2; second type I K homology (KH) RNA-binding domain found in heterogeneous nuclear ribonucleoprotein K (hnRNP K) and similar proteins
      cd22434
      Location:299 → 371
      KH-I_HNRNPK_rpt3; third type I K homology (KH) RNA-binding domain found in heterogeneous nuclear ribonucleoprotein K (hnRNP K) and similar proteins
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