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    Dmc1 DNA meiotic recombinase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362960, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dmc1provided by RGD
    Official Full Name
    DNA meiotic recombinase 1provided by RGD
    Primary source
    RGD:1307611
    See related
    EnsemblRapid:ENSRNOG00000013807 AllianceGenome:RGD:1307611
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Dmc1h
    Summary
    Predicted to enable DNA binding activity; catalytic activity, acting on DNA; and identical protein binding activity. Predicted to be involved in DNA recombination and chromosome organization involved in meiotic cell cycle. Predicted to act upstream of or within germ cell development; meiosis I; and ovarian follicle development. Predicted to be located in chromosome, telomeric region and lateral element. Predicted to be active in condensed nuclear chromosome and site of double-strand break. Orthologous to human DMC1 (DNA meiotic recombinase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 21.6), Lung (RPKM 10.2) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dmc1 in Genome Data Viewer
    Location:
    7q34
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (113005278..113047854, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (111124888..111167465, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (120796217..120840524, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene KDEL endoplasmic reticulum protein retention receptor 3 Neighboring gene DEAD-box helicase 17 Neighboring gene family with sequence similarity 227, member A Neighboring gene uncharacterized LOC134479938 Neighboring gene chibby 1, beta catenin antagonist

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mei1 is epistatic to Dmc1 during mouse meiosis. Reinholdt LG, et al. Chromosoma, 2005 Jul. PMID 15928951
    2. Toward the genetics of mammalian reproduction: induction and mapping of gametogenesis mutants in mice. Ward JO, et al. Biol Reprod, 2003 Nov. PMID 12855593
    3. Rhox13 is translated in premeiotic germ cells in male and female mice and is regulated by NANOS2 in the male. Geyer CB, et al. Biol Reprod, 2012 Apr. PMID 22190708, Free PMC Article
    4. Distinct DNA-damage-dependent and -independent responses drive the loss of oocytes in recombination-defective mouse mutants. Di Giacomo M, et al. Proc Natl Acad Sci U S A, 2005 Jan 18. PMID 15640358, Free PMC Article
    5. Zscan4 regulates telomere elongation and genomic stability in ES cells. Zalzman M, et al. Nature, 2010 Apr 8. PMID 20336070, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent DNA damage sensor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent activity, acting on DNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP-dependent activity, acting on DNA ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA strand exchange activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA strand exchange activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables double-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables single-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA recombinase assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA strand invasion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromosome organization involved in meiotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in double-strand break repair involved in meiotic recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within gamete generation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within homologous chromosome pairing at meiosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within male meiosis I ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within oocyte maturation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within oogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within ovarian follicle development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in reciprocal meiotic recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in reciprocal meiotic recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within spermatid development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in condensed nuclear chromosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in condensed nuclear chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lateral element ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in site of double-strand break ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    meiotic recombination protein DMC1/LIM15 homolog
    Names
    DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130567.1 → NP_001124039.1  meiotic recombination protein DMC1/LIM15 homolog

      See identical proteins and their annotated locations for NP_001124039.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473950
      UniProtKB/TrEMBL
      A0A8I6AK83, A6HSS6, D3ZJ85
      Related
      ENSRNOP00000018526.4, ENSRNOT00000018526.7
      Conserved Domains (1) summary
      TIGR02238
      Location:24 → 338
      recomb_DMC1; meiotic recombinase Dmc1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      113005278..113047854 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039079586.2 → XP_038935514.1  meiotic recombination protein DMC1/LIM15 homolog isoform X1

      Conserved Domains (1) summary
      cd19514
      Location:22 → 249
      DMC1; homologous-pairing protein DMC1
    Nucleotide Protein Strain
    Heading Accession and Version

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