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    Cntln centlein, centrosomal protein [ Mus musculus (house mouse) ]

    Gene ID: 338349, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cntlnprovided by MGI
    Official Full Name
    centlein, centrosomal proteinprovided by MGI
    Primary source
    MGI:MGI:2443104
    See related
    Ensembl:ENSMUSG00000038070 AllianceGenome:MGI:2443104
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    B430108F07Rik; D530005L17Rik
    Summary
    Predicted to enable protein domain specific binding activity; protein kinase binding activity; and protein-macromolecule adaptor activity. Acts upstream of or within several processes, including regulation of protein localization; single fertilization; and spermatogenesis. Is active in sperm head-tail coupling apparatus. Orthologous to human CNTLN (centlein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 3.3), limb E14.5 (RPKM 2.9) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cntln in Genome Data Viewer
    Location:
    4 C4; 4 40.2 cM
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (84800024..85050160)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (84881787..85131923)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene 12415 Neighboring gene STARR-seq mESC enhancer starr_10670 Neighboring gene STARR-seq mESC enhancer starr_10671 Neighboring gene predicted gene, 27579 Neighboring gene STARR-seq mESC enhancer starr_10672 Neighboring gene STARR-seq mESC enhancer starr_10673 Neighboring gene dimethyladenosine transferase pseudogene Neighboring gene predicted gene 12419 Neighboring gene STARR-seq mESC enhancer starr_10675 Neighboring gene STARR-seq mESC enhancer starr_10676 Neighboring gene RAN, member RAS oncogene family pseudogene Neighboring gene SH3-domain GRB2-like 2 Neighboring gene phosphoglycerate mutase 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Centlein, a novel microtubule-associated protein stabilizing microtubules and involved in neurite formation. Jing Z, et al. Biochem Biophys Res Commun, 2016 Apr 1. PMID 26915804
    2. The missing linker between SUN5 and PMFBP1 in sperm head-tail coupling apparatus. Zhang Y, et al. Nat Commun, 2021 Aug 13. PMID 34389728, Free PMC Article
    3. Identification and characterization of the novel centrosomal protein centlein. Makino K, et al. Biochem Biophys Res Commun, 2008 Feb 22. PMID 18086554
    4. A direct interaction between CENTLEIN and RABIN8 is required for primary cilium formation. Li L, et al. Acta Biochim Biophys Sin (Shanghai), 2023 Jul 20. PMID 37475549, Free PMC Article
    5. A global genomic transcriptional code associated with CNS-expressed genes. Bailey PJ, et al. Exp Cell Res, 2006 Oct 1. PMID 16919269

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A direct interaction between CENTLEIN and RABIN8 is required for primary cilium formation.
      Title: A direct interaction between CENTLEIN and RABIN8 is required for primary cilium formation.
    2. Taken together, we propose that centlein is involved in MT stability and neuritogenesis in vivo.
      Title: Centlein, a novel microtubule-associated protein stabilizing microtubules and involved in neurite formation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-macromolecule adaptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in centriole-centriole cohesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in centriole-centriole cohesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in centriole-centriole cohesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein localization to organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein-containing complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within single fertilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centriole IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in sperm head-tail coupling apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    centlein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001405430.1 → NP_001392359.1  centlein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL805906, AL806524, BX470174
      UniProtKB/Swiss-Prot
      A0PJC6, A2AM05, Q3TNP8, Q5EBN8, Q8C748, Q8C9U3, Q8CD25, Q8CE32, Q8R2F0, Q8R2P3
      Related
      ENSMUSP00000044138.7, ENSMUST00000047023.13

    2. NM_001405431.1 → NP_001392360.1  centlein isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL805906, BX470174

    3. NM_175275.5 → NP_780484.2  centlein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL805906, AL806524, BX470174
      Consensus CDS
      CCDS51216.1
      UniProtKB/Swiss-Prot
      A2AM05
      Related
      ENSMUSP00000130491.3, ENSMUST00000169371.9
      Conserved Domains (1) summary
      TIGR02168
      Location:523 → 1297
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    4. NM_177385.5 → NP_796359.1  centlein isoform 2

      See identical proteins and their annotated locations for NP_796359.1

      Status: VALIDATED

      Source sequence(s)
      AL805906, BX470174
      Consensus CDS
      CCDS18302.1
      UniProtKB/Swiss-Prot
      A2AM05
      Related
      ENSMUSP00000099883.4, ENSMUST00000102819.10
      Conserved Domains (1) summary
      pfam08537
      Location:155 → 248
      NBP1; Fungal Nap binding protein NBP1

    RNA

    1. NR_175938.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL805906, AL806524, BX470174

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      84800024..85050160
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006538028.5 → XP_006538091.1  centlein isoform X4

      Conserved Domains (1) summary
      COG1196
      Location:130 → 774
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    2. XM_006538027.4 → XP_006538090.1  centlein isoform X2

      Conserved Domains (2) summary
      COG1196
      Location:24 → 622
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:369 → 1144
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    3. XM_036164203.1 → XP_036020096.1  centlein isoform X5

      Conserved Domains (1) summary
      TIGR02168
      Location:66 → 841
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    4. XM_006538029.4 → XP_006538092.1  centlein isoform X5

      Conserved Domains (1) summary
      TIGR02168
      Location:66 → 841
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    5. XM_011250056.4 → XP_011248358.1  centlein isoform X6

      Conserved Domains (2) summary
      COG1196
      Location:1 → 707
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:407 → 738
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    6. XM_036164204.1 → XP_036020097.1  centlein isoform X7

      Conserved Domains (2) summary
      COG1196
      Location:52 → 700
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:394 → 725
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    RNA

    1. XR_004941927.1 RNA Sequence

    2. XR_881069.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2AM05.1 GenPept UniProtKB/Swiss-Prot:A2AM05

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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