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    RPL18A ribosomal 60S subunit protein L18A [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854029, updated on 9-Dec-2024

    Summary

    Official Symbol
    RPL18A
    Official Full Name
    ribosomal 60S subunit protein L18A
    Primary source
    SGD:S000005480
    Locus tag
    YOL120C
    See related
    AllianceGenome:SGD:S000005480; FungiDB:YOL120C; VEuPathDB:YOL120C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    RP28A
    Summary
    Predicted to enable RNA binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in cytoplasmic translation. Part of cytosolic large ribosomal subunit. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 18. Orthologous to human RPL18 (ribosomal protein L18). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See RPL18A in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    2
    Sequence:
    Chromosome: XV; NC_001147.6 (93395..94402, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene divalent metal ion transporter SMF1 Neighboring gene ribosomal 40S subunit protein S19A Neighboring gene Mch4p Neighboring gene uncharacterized protein

    Interactions

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding  
    enables structural constituent of ribosome  
    enables structural constituent of ribosome PubMed 
    enables structural constituent of ribosome  
    Component Evidence Code Pubs
    located_in cytoplasm  
    part_of cytosolic large ribosomal subunit  
    part_of cytosolic large ribosomal subunit PubMed 
    part_of ribonucleoprotein complex  
    located_in ribosome  

    General protein information

    Preferred Names
    ribosomal 60S subunit protein L18A
    NP_014521.1
    • Ribosomal 60S subunit protein L18A; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18A has a paralog, RPL18B, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      93395..94402 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183374.1 → NP_014521.1  TPA: ribosomal 60S subunit protein L18A [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014521.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0P3, P07279, P0CX49, P0CX50
      UniProtKB/TrEMBL
      A6ZN91, B3LIU6, C8ZGM2, G2WLG7, N1NWY0
      Conserved Domains (1) summary
      pfam17135
      Location:2 → 186
      Ribosomal_L18; Ribosomal protein 60S L18 and 50S L18e
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