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    TLR2 toll like receptor 2 [ Homo sapiens (human) ]

    Gene ID: 7097, updated on 3-Dec-2024

    Summary

    Official Symbol
    TLR2provided by HGNC
    Official Full Name
    toll like receptor 2provided by HGNC
    Primary source
    HGNC:HGNC:11848
    See related
    Ensembl:ENSG00000137462 MIM:603028; AllianceGenome:HGNC:11848
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TIL4; CD282
    Summary
    The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. This protein is a cell-surface protein that can form heterodimers with other TLR family members to recognize conserved molecules derived from microorganisms known as pathogen-associated molecular patterns (PAMPs). Activation of TLRs by PAMPs leads to an up-regulation of signaling pathways to modulate the host's inflammatory response. This gene is also thought to promote apoptosis in response to bacterial lipoproteins. This gene has been implicated in the pathogenesis of several autoimmune diseases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
    Expression
    Broad expression in appendix (RPKM 15.9), bone marrow (RPKM 12.6) and 18 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TLR2 in Genome Data Viewer
    Location:
    4q31.3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (153684280..153710637)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (157008777..157030716)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (154605432..154627412)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene transmembrane 131 like Neighboring gene uncharacterized LOC105377498 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:154455569-154456145 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:154456146-154456721 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:154457236-154457741 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15764 Neighboring gene toll like receptor 2 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:154561385-154561884 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15765 Neighboring gene WD repeat domain 45 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15766 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15767 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_74840 Neighboring gene uncharacterized LOC105377499 Neighboring gene ring finger protein 175 Neighboring gene Sharpr-MPRA regulatory region 15425 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_74848 Neighboring gene secreted frizzled related protein 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    HIV-1 replication is enhanced by TLR2; when neutralized with anti-TLR2 antibody HIV-1 (BAL) proviral DNA is decreased relative to non-specific antibody in TZM-bl-2 cells PubMed
    HIV-1 infection is enhanced by TLR2 stimulation via Pam3CSK4 (a synthetic bacterial TLR2/1 ligand) in TZM-bl cells PubMed
    HIV-1 replication is enhanced by TLR2 stimulation or TNF treatment in Langerhans cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env The binding of soluble HIV-1 gp120 to TLR2 or TLR4 results in upregulation of the TNF-alpha and IL-8 production through NF-kappaB activation PubMed
    env Treatment of HIV-1 gp120 to astroglia displays significant increases in TLR2 PubMed
    Envelope transmembrane glycoprotein gp41 env Fully processed HIV-1 Env protein, once expressed on the cellular membrane, inhibits TLR2 activation PubMed
    env HIV-1 gp41 binds TLR2 (from TZM-bl-2 cell lysates) PubMed
    env siRNA knockdown of TLR2 in a HIV-1 gp41-exposed TLR2 transgene cell line, TZM-bl-2, decreases IL-8 production PubMed
    env Exposure of anti-TLR2 antibody-treated primary T cells to HIV-1 gp41 decreases IL-8 production PubMed
    env Exposure of TLR2 transgene cell lines (TZM-bl-2, HEK293-TLR2/1, HEK293-TLR2/6) to HIV-1 gp41 increases the production of IL-8 PubMed
    env The HIV-1 gp41 transmembrane domain (TMD) inhibits the interaction between the TMDs of TLR2 and TLR6 in vitro PubMed
    env The transmembrane domain (TMD) of HIV-1 gp41 directly interacts with the TLR2 TMD within the membrane, partially through its GxxxG dimerization motif PubMed
    env The HIV-1 gp41 transmembrane domain inhibits TLR2-induced activation of ERK1/2, and secretion of TNF-alpha, MCP-1, and IL-6 PubMed
    env The binding of soluble TLR2 to HIV-1 MA, CA, or gp41 inhibits the nuclear translocation of NFKB p65 subunit and downregulates IL-8 and CCR5 expression, leading to inhibition of HIV-1 infection in cells PubMed
    Nef nef HIV-1 Nef-mediated upregulation of TLR2 increases regulatory T cells (Tregs) and inhibits the proliferation of PBMCs PubMed
    nef HIV-1 Nef upregulates TLR2 expression via NF-kappaB activation in THP-1 cells PubMed
    Tat tat Treatment of HIV-1 Tat to astroglia displays significant increases in TLR2 expression PubMed
    capsid gag HIV-1 CA binds TLR2 (from TZM-bl-2 cell lysates) PubMed
    gag Exposure of the TLR2 transgene cell line, HEK293-TLR2/6, to HIV-1 CA (p24) increases the production of IL-8 BUT NOT in the TLR2 transgene cell lines, TZM-bl-2 and HEK293-TLR2/1 PubMed
    gag Exposure of anti-TLR2 antibody-treated primary T cells to HIV-1 CA (p24) decreases IL-8 production PubMed
    gag The binding of soluble TLR2 to HIV-1 MA, CA, or gp41 inhibits the nuclear translocation of NFKB p65 subunit and downregulates IL-8 and CCR5 expression, leading to inhibition of HIV-1 infection in cells PubMed
    matrix gag HIV-1 MA (p17) binds TLR2 (from TZM-bl-2 cell lysates) PubMed
    gag siRNA knockdown of TLR2 in a HIV-1 MA (p17)-exposed TLR2 transgene cell line, TZM-bl-2, decreases IL-8 production PubMed
    gag Exposure of anti-TLR2 antibody-treated primary T cells to HIV-1 MA (p17) decreases IL-8 production PubMed
    gag Exposure of TLR2 transgene cell lines (TZM-bl-2, HEK293-TLR2/1, HEK293-TLR2/6) to HIV-1 MA (p17) increases the production of IL-8 PubMed
    gag The binding of soluble TLR2 to HIV-1 MA, CA, or gp41 inhibits the nuclear translocation of NFKB p65 subunit and downregulates IL-8 and CCR5 expression, leading to inhibition of HIV-1 infection in cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables NAD+ nucleotidase, cyclic ADP-ribose generating IEA
    Inferred from Electronic Annotation
    more info
     
    enables Toll-like receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables amyloid-beta binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables amyloid-beta binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables lipopolysaccharide binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables lipopolysaccharide immune receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables pattern recognition receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables peptidoglycan binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables triacyl lipopeptide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables triacyl lipopeptide binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in I-kappaB phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cellular response to bacterial lipopeptide TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to diacyl bacterial lipopeptide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to diacyl bacterial lipopeptide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to lipoteichoic acid IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to lipoteichoic acid IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to triacyl bacterial lipopeptide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to triacyl bacterial lipopeptide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to type II interferon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in central nervous system myelin formation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in defense response to Gram-positive bacterium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in defense response to virus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within detection of diacyl bacterial lipopeptide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within detection of triacyl bacterial lipopeptide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in immune response TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in innate immune response NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in innate immune response TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in learning ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in leukotriene metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lipopolysaccharide-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in microglia development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in microglial cell activation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of phagocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of synapse assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in nitric oxide metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of NF-kappaB transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of NF-kappaB transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cellular response to macrophage colony-stimulating factor stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of chemokine production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of inflammatory response IC
    Inferred by Curator
    more info
    PubMed 
    involved_in positive regulation of inflammatory response IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of interferon-beta production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of interleukin-10 production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of interleukin-12 production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of interleukin-18 production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of interleukin-6 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of interleukin-6 production IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of positive regulation of interleukin-8 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of interleukin-8 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of interleukin-8 production IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of matrix metallopeptidase secretion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of non-canonical NF-kappaB signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of oligodendrocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of tumor necrosis factor production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to fatty acid IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to insulin IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to progesterone IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to toxic substance IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in toll-like receptor 2 signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in toll-like receptor TLR6:TLR2 signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in toll-like receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in toll-like receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in toll-like receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of Toll-like receptor 1-Toll-like receptor 2 protein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of Toll-like receptor 1-Toll-like receptor 2 protein complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of Toll-like receptor 2-Toll-like receptor 6 protein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of Toll-like receptor 2-Toll-like receptor 6 protein complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in cell body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in phagocytic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of receptor complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in secretory granule membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    toll-like receptor 2
    Names
    toll/interleukin-1 receptor-like protein 4
    NP_001305716.1
    NP_001305718.1
    NP_001305719.1
    NP_001305720.1
    NP_001305722.1
    NP_001305724.1
    NP_001305725.1
    NP_003255.2
    XP_011530517.1
    XP_011530518.1
    XP_016864062.1
    XP_016864064.1
    XP_047272067.1
    XP_047272068.1
    XP_047272069.1
    XP_047272070.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016229.2 RefSeqGene

      Range
      5002..26982
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001318787.2NP_001305716.1  toll-like receptor 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1-8 all encode the same protein.
      Source sequence(s)
      AK125659, AW614989, BC033756, BQ017238, CB528396, DA582193
      Consensus CDS
      CCDS3784.1
      UniProtKB/Swiss-Prot
      B3Y612, D1CS45, D1CS48, D1CS49, O15454, O60603, Q8NI00
      UniProtKB/TrEMBL
      A0A0S2Z4S4, B3KWR9
      Related
      ENSP00000496208.2, ENST00000643501.2
      Conserved Domains (6) summary
      smart00082
      Location:533586
      LRRCT; Leucine rich repeat C-terminal domain
      smart00255
      Location:640784
      TIR; Toll - interleukin 1 - resistance
      sd00033
      Location:5477
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:77135
      LRR_8; Leucine rich repeat
      cl26018
      Location:324558
      NEL; C-terminal novel E3 ligase, LRR-interacting
      cl26793
      Location:40206
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    2. NM_001318789.2NP_001305718.1  toll-like receptor 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-8 all encode the same protein.
      Source sequence(s)
      AF424051, AK125659, AW614989, BC033756, BQ017238, CB528396
      Consensus CDS
      CCDS3784.1
      UniProtKB/Swiss-Prot
      B3Y612, D1CS45, D1CS48, D1CS49, O15454, O60603, Q8NI00
      UniProtKB/TrEMBL
      A0A0S2Z4S4, B3KWR9
      Related
      ENSP00000494425.1, ENST00000642700.2
      Conserved Domains (6) summary
      smart00082
      Location:533586
      LRRCT; Leucine rich repeat C-terminal domain
      smart00255
      Location:640784
      TIR; Toll - interleukin 1 - resistance
      sd00033
      Location:5477
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:77135
      LRR_8; Leucine rich repeat
      cl26018
      Location:324558
      NEL; C-terminal novel E3 ligase, LRR-interacting
      cl26793
      Location:40206
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    3. NM_001318790.2NP_001305719.1  toll-like receptor 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-8 all encode the same protein.
      Source sequence(s)
      AF424051, AK125659, AW614989, BC033756, BQ017238, CB528396, DA870971
      Consensus CDS
      CCDS3784.1
      UniProtKB/Swiss-Prot
      B3Y612, D1CS45, D1CS48, D1CS49, O15454, O60603, Q8NI00
      UniProtKB/TrEMBL
      A0A0S2Z4S4, B3KWR9
      Related
      ENSP00000519702.1, ENST00000714433.1
      Conserved Domains (6) summary
      smart00082
      Location:533586
      LRRCT; Leucine rich repeat C-terminal domain
      smart00255
      Location:640784
      TIR; Toll - interleukin 1 - resistance
      sd00033
      Location:5477
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:77135
      LRR_8; Leucine rich repeat
      cl26018
      Location:324558
      NEL; C-terminal novel E3 ligase, LRR-interacting
      cl26793
      Location:40206
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    4. NM_001318791.2NP_001305720.1  toll-like receptor 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1-8 all encode the same protein.
      Source sequence(s)
      AF424052, AK125659, AW614989, BC033756, BQ017238, CB528396
      Consensus CDS
      CCDS3784.1
      UniProtKB/Swiss-Prot
      B3Y612, D1CS45, D1CS48, D1CS49, O15454, O60603, Q8NI00
      UniProtKB/TrEMBL
      A0A0S2Z4S4, B3KWR9
      Related
      ENSP00000519703.1, ENST00000714434.1
      Conserved Domains (6) summary
      smart00082
      Location:533586
      LRRCT; Leucine rich repeat C-terminal domain
      smart00255
      Location:640784
      TIR; Toll - interleukin 1 - resistance
      sd00033
      Location:5477
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:77135
      LRR_8; Leucine rich repeat
      cl26018
      Location:324558
      NEL; C-terminal novel E3 ligase, LRR-interacting
      cl26793
      Location:40206
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    5. NM_001318793.2NP_001305722.1  toll-like receptor 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1-8 all encode the same protein.
      Source sequence(s)
      AF424051, AK125659, AW614989, BC033756, BQ017238, CB528396, DA460298
      Consensus CDS
      CCDS3784.1
      UniProtKB/Swiss-Prot
      B3Y612, D1CS45, D1CS48, D1CS49, O15454, O60603, Q8NI00
      UniProtKB/TrEMBL
      A0A0S2Z4S4, B3KWR9
      Related
      ENSP00000519700.1, ENST00000714431.1
      Conserved Domains (6) summary
      smart00082
      Location:533586
      LRRCT; Leucine rich repeat C-terminal domain
      smart00255
      Location:640784
      TIR; Toll - interleukin 1 - resistance
      sd00033
      Location:5477
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:77135
      LRR_8; Leucine rich repeat
      cl26018
      Location:324558
      NEL; C-terminal novel E3 ligase, LRR-interacting
      cl26793
      Location:40206
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    6. NM_001318795.2NP_001305724.1  toll-like receptor 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Variants 1-8 all encode the same protein.
      Source sequence(s)
      AF424053, AK125659, AW614989, BC033756, BQ017238, CB528396
      Consensus CDS
      CCDS3784.1
      UniProtKB/Swiss-Prot
      B3Y612, D1CS45, D1CS48, D1CS49, O15454, O60603, Q8NI00
      UniProtKB/TrEMBL
      A0A0S2Z4S4, B3KWR9
      Conserved Domains (6) summary
      smart00082
      Location:533586
      LRRCT; Leucine rich repeat C-terminal domain
      smart00255
      Location:640784
      TIR; Toll - interleukin 1 - resistance
      sd00033
      Location:5477
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:77135
      LRR_8; Leucine rich repeat
      cl26018
      Location:324558
      NEL; C-terminal novel E3 ligase, LRR-interacting
      cl26793
      Location:40206
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    7. NM_001318796.2NP_001305725.1  toll-like receptor 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 1. Variants 1-8 all encode the same protein.
      Source sequence(s)
      AF424049, AK125659, AW614989, BC033756, BQ017238, CB528396
      Consensus CDS
      CCDS3784.1
      UniProtKB/Swiss-Prot
      B3Y612, D1CS45, D1CS48, D1CS49, O15454, O60603, Q8NI00
      UniProtKB/TrEMBL
      A0A0S2Z4S4, B3KWR9
      Related
      ENSP00000495339.1, ENST00000642580.1
      Conserved Domains (6) summary
      smart00082
      Location:533586
      LRRCT; Leucine rich repeat C-terminal domain
      smart00255
      Location:640784
      TIR; Toll - interleukin 1 - resistance
      sd00033
      Location:5477
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:77135
      LRR_8; Leucine rich repeat
      cl26018
      Location:324558
      NEL; C-terminal novel E3 ligase, LRR-interacting
      cl26793
      Location:40206
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    8. NM_003264.5NP_003255.2  toll-like receptor 2 precursor

      See identical proteins and their annotated locations for NP_003255.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-8 all encode the same protein.
      Source sequence(s)
      AF424049, AI493140, AW614989, BC033756, BQ017238, DQ012267
      Consensus CDS
      CCDS3784.1
      UniProtKB/Swiss-Prot
      B3Y612, D1CS45, D1CS48, D1CS49, O15454, O60603, Q8NI00
      UniProtKB/TrEMBL
      A0A0S2Z4S4, B3KWR9
      Related
      ENSP00000493968.2, ENST00000646900.2
      Conserved Domains (6) summary
      smart00082
      Location:533586
      LRRCT; Leucine rich repeat C-terminal domain
      smart00255
      Location:640784
      TIR; Toll - interleukin 1 - resistance
      sd00033
      Location:5477
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:77135
      LRR_8; Leucine rich repeat
      cl26018
      Location:324558
      NEL; C-terminal novel E3 ligase, LRR-interacting
      cl26793
      Location:40206
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      153684280..153710637
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047416111.1XP_047272067.1  toll-like receptor 2 isoform X1

      UniProtKB/Swiss-Prot
      B3Y612, D1CS45, D1CS48, D1CS49, O15454, O60603, Q8NI00
      UniProtKB/TrEMBL
      A0A0S2Z4S4, B3KWR9
    2. XM_047416113.1XP_047272069.1  toll-like receptor 2 isoform X1

      UniProtKB/Swiss-Prot
      B3Y612, D1CS45, D1CS48, D1CS49, O15454, O60603, Q8NI00
      UniProtKB/TrEMBL
      A0A0S2Z4S4, B3KWR9
    3. XM_017008573.2XP_016864062.1  toll-like receptor 2 isoform X1

      UniProtKB/Swiss-Prot
      B3Y612, D1CS45, D1CS48, D1CS49, O15454, O60603, Q8NI00
      UniProtKB/TrEMBL
      A0A0S2Z4S4, B3KWR9
      Related
      ENSP00000496676.2, ENST00000646219.2
      Conserved Domains (6) summary
      smart00082
      Location:533586
      LRRCT; Leucine rich repeat C-terminal domain
      smart00255
      Location:640784
      TIR; Toll - interleukin 1 - resistance
      sd00033
      Location:5477
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:77135
      LRR_8; Leucine rich repeat
      cl26018
      Location:324558
      NEL; C-terminal novel E3 ligase, LRR-interacting
      cl26793
      Location:40206
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    4. XM_047416112.1XP_047272068.1  toll-like receptor 2 isoform X1

      UniProtKB/Swiss-Prot
      B3Y612, D1CS45, D1CS48, D1CS49, O15454, O60603, Q8NI00
      UniProtKB/TrEMBL
      A0A0S2Z4S4, B3KWR9
    5. XM_017008575.2XP_016864064.1  toll-like receptor 2 isoform X1

      UniProtKB/Swiss-Prot
      B3Y612, D1CS45, D1CS48, D1CS49, O15454, O60603, Q8NI00
      UniProtKB/TrEMBL
      A0A0S2Z4S4, B3KWR9
      Related
      ENSP00000519704.1, ENST00000714435.1
      Conserved Domains (6) summary
      smart00082
      Location:533586
      LRRCT; Leucine rich repeat C-terminal domain
      smart00255
      Location:640784
      TIR; Toll - interleukin 1 - resistance
      sd00033
      Location:5477
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:77135
      LRR_8; Leucine rich repeat
      cl26018
      Location:324558
      NEL; C-terminal novel E3 ligase, LRR-interacting
      cl26793
      Location:40206
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    6. XM_011532215.3XP_011530517.1  toll-like receptor 2 isoform X1

      See identical proteins and their annotated locations for XP_011530517.1

      UniProtKB/Swiss-Prot
      B3Y612, D1CS45, D1CS48, D1CS49, O15454, O60603, Q8NI00
      UniProtKB/TrEMBL
      A0A0S2Z4S4, B3KWR9
      Conserved Domains (6) summary
      smart00082
      Location:533586
      LRRCT; Leucine rich repeat C-terminal domain
      smart00255
      Location:640784
      TIR; Toll - interleukin 1 - resistance
      sd00033
      Location:5477
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:77135
      LRR_8; Leucine rich repeat
      cl26018
      Location:324558
      NEL; C-terminal novel E3 ligase, LRR-interacting
      cl26793
      Location:40206
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    7. XM_011532216.3XP_011530518.1  toll-like receptor 2 isoform X1

      See identical proteins and their annotated locations for XP_011530518.1

      UniProtKB/Swiss-Prot
      B3Y612, D1CS45, D1CS48, D1CS49, O15454, O60603, Q8NI00
      UniProtKB/TrEMBL
      A0A0S2Z4S4, B3KWR9
      Conserved Domains (6) summary
      smart00082
      Location:533586
      LRRCT; Leucine rich repeat C-terminal domain
      smart00255
      Location:640784
      TIR; Toll - interleukin 1 - resistance
      sd00033
      Location:5477
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:77135
      LRR_8; Leucine rich repeat
      cl26018
      Location:324558
      NEL; C-terminal novel E3 ligase, LRR-interacting
      cl26793
      Location:40206
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    8. XM_047416114.1XP_047272070.1  toll-like receptor 2 isoform X1

      UniProtKB/Swiss-Prot
      B3Y612, D1CS45, D1CS48, D1CS49, O15454, O60603, Q8NI00
      UniProtKB/TrEMBL
      A0A0S2Z4S4, B3KWR9

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      157008777..157030716
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)