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    ANB1 translation elongation factor eIF-5A [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853506, updated on 9-Dec-2024

    Summary

    Official Symbol
    ANB1
    Official Full Name
    translation elongation factor eIF-5A
    Primary source
    SGD:S000003808
    Locus tag
    YJR047C
    See related
    AllianceGenome:SGD:S000003808; FungiDB:YJR047C; VEuPathDB:YJR047C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    HYP1; TIF51B
    Summary
    Predicted to enable RNA binding activity; ribosome binding activity; and translation elongation factor activity. Involved in positive regulation of translational elongation and translational frameshifting. Located in cytosolic ribosome. Orthologous to several human genes including EIF5AL1 (eukaryotic translation initiation factor 5A like 1) and EIF5A2 (eukaryotic translation initiation factor 5A2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See ANB1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (524908..525381, complement)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Tah11p Neighboring gene tRNA-Ser Neighboring gene cytochrome c isoform 1 Neighboring gene NADH/NAD(+) kinase

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding  
    enables RNA binding PubMed 
    enables ribosome binding  
    enables ribosome binding PubMed 
    enables translation elongation factor activity  
    enables translation elongation factor activity  
    enables translation elongation factor activity PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm  
    located_in cytosolic ribosome PubMed 

    General protein information

    Preferred Names
    translation elongation factor eIF-5A
    NP_012581.3
    • Translation elongation factor eIF-5A; previously thought to function in translation initiation; undergoes an essential hypusination modification; expressed under anaerobic conditions; ANB1 has a paralog, HYP2, that arose from the whole genome duplication; human EIF5A complements the inviability of the yeast hyp2 anb1 double null mutant

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      524908..525381 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181705.3 → NP_012581.3  TPA: translation elongation factor eIF-5A [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012581.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWL8, P19211
      UniProtKB/TrEMBL
      A6ZQ06, B3LQD6, D3UF95, G2WCJ9, G2WH52, N1P131
      Conserved Domains (1) summary
      cl30809
      Location:1 → 154
      PLN03107; eukaryotic translation initiation factor 5A; Provisional
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