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    Gp150 Gp150 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37549, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gp150provided by FlyBase
    Official Full Name
    Gp150provided by FlyBase
    Primary source
    FLYBASE:FBgn0013272
    Locus tag
    Dmel_CG5820
    See related
    AllianceGenome:FB:FBgn0013272
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:fe2A1; CG5820; CT18251; Dmel\CG5820; gp150; GP150; l(2)52A; p150
    Summary
    Involved in cell surface receptor protein tyrosine phosphatase signaling pathway and compound eye development. Located in plasma membrane. Is expressed in several structures, including cuboidal/columnar epithelium; ganglia; glial cell; imaginal disc; and larval midline neurons. Orthologous to human NRROS (negative regulator of reactive oxygen species) and TSKU (tsukushi, small leucine rich proteoglycan). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Gp150 in Genome Data Viewer
    Location:
    58D3-58D3; 2-99 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (22317662..22329416)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (18205167..18216921)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene windpipe Neighboring gene long non-coding RNA:CR44758 Neighboring gene long non-coding RNA:CR44756 Neighboring gene Liprin-gamma Neighboring gene uncharacterized protein Neighboring gene Type III alcohol dehydrogenase Neighboring gene uncharacterized protein Neighboring gene polar granule component

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. P[52A-GAL4] is an insertion in the Drosophila GP150 gene. Melnattur K, et al. Genesis, 2002 Sep-Oct. PMID 12324943
    2. Conformational basis for substrate recruitment in protein tyrosine phosphatase 10D. Madan LL, et al. Biochemistry, 2011 Nov 22. PMID 22007620, Free PMC Article
    3. An adhesion molecule-like protein that interacts with and is a substrate for a Drosophila receptor-linked protein tyrosine phosphatase. Tian SS, et al. J Biol Chem, 1994 Nov 11. PMID 7961789
    4. Evolutionary conservation of the leucine-rich repeat transmembrane protein Gp150 in Drosophila and Bombyx. Dhulkotia D, et al. Dev Genes Evol, 2000 Mar. PMID 11180815
    5. Cooperative functions of the reaper and head involution defective genes in the programmed cell death of Drosophila central nervous system midline cells. Zhou L, et al. Proc Natl Acad Sci U S A, 1997 May 13. PMID 9144202, Free PMC Article

    See all (76) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in cell surface receptor protein tyrosine phosphatase signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in compound eye development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Gp150
    Names
    CG5820-PA
    CG5820-PB
    CG5820-PC
    CG5820-PD
    CG5820-PE
    CG5820-PF
    Gp150-PA
    Gp150-PB
    Gp150-PC
    Gp150-PD
    Gp150-PE
    Gp150-PF
    anon-fast-evolving-2A1
    glycoprotein 150

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      22317662..22329416
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_166529.2 → NP_726192.1  Gp150, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726192.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q24007, Q94531, Q95PA9
      Related
      FBpp0071728
      Conserved Domains (4) summary
      cd00116
      Location:561 → 720
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:708 → 720
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:368 → 390
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:581 → 641
      LRR_8; Leucine rich repeat

    2. NM_166528.2 → NP_726191.1  Gp150, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726191.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q24007, Q94531, Q95PA9
      Related
      FBpp0071727
      Conserved Domains (4) summary
      cd00116
      Location:561 → 720
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:708 → 720
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:368 → 390
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:581 → 641
      LRR_8; Leucine rich repeat

    3. NM_166527.2 → NP_726190.1  Gp150, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726190.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q24007, Q94531, Q95PA9
      Related
      FBpp0071726
      Conserved Domains (4) summary
      cd00116
      Location:561 → 720
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:708 → 720
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:368 → 390
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:581 → 641
      LRR_8; Leucine rich repeat

    4. NM_001299784.1 → NP_001286713.1  Gp150, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286713.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LGB0, Q95PA9
      Conserved Domains (4) summary
      cd00116
      Location:554 → 713
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:701 → 713
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:361 → 383
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:574 → 634
      LRR_8; Leucine rich repeat

    5. NM_057701.4 → NP_477049.2  Gp150, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477049.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6AWQ3, Q8MLT4
      Related
      FBpp0071729
      Conserved Domains (4) summary
      cd00116
      Location:586 → 745
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:733 → 745
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:393 → 415
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:606 → 666
      LRR_8; Leucine rich repeat

    6. NM_001299785.1 → NP_001286714.1  Gp150, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286714.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q24007, Q94531, Q95PA9
      Conserved Domains (4) summary
      cd00116
      Location:561 → 720
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:708 → 720
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:368 → 390
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:581 → 641
      LRR_8; Leucine rich repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LGB0 A0A0B4LGB0
    Q24007 Q24007
    Q6AWQ3 Q6AWQ3
    Q7JNM8 Q7JNM8
    Q8MLT4 Q8MLT4
    Q95PA9 Q95PA9

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