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    Syx5 Syntaxin 5 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34966, updated on 4-Jan-2025

    Summary

    Official Symbol
    Syx5provided by FlyBase
    Official Full Name
    Syntaxin 5provided by FlyBase
    Primary source
    FLYBASE:FBgn0011708
    Locus tag
    Dmel_CG4214
    See related
    AllianceGenome:FB:FBgn0011708
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-35Fb; anon-35Fd; BG:DS02740.12; CG4214; Dmel\CG4214; DmSyx5; dsed5; dSed5; dSed5p; dSyx5; II; l(2)35Ff; sed5; Sed5; SED5; STX5; syn5; SYN5; Synx5; Syx; syx5; Syx5A
    Summary
    Enables SNAP receptor activity and protein homodimerization activity. Involved in several processes, including intracellular copper ion homeostasis; larval lymph gland hemopoiesis; and male meiosis cytokinesis. Located in cis-Golgi network. Is expressed in adult head. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type II. Orthologous to human STX5 (syntaxin 5). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
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    Genomic context

    See Syx5 in Genome Data Viewer
    Location:
    35F1-35F1; 2-52 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (16307346..16309274)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (16307346..16309274)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Glia maturation factor Neighboring gene crossover suppressor on 2 of Manheim Neighboring gene uncharacterized protein Neighboring gene cornichon Neighboring gene fizzy Neighboring gene cactus

    Genomic regions, transcripts, and products

    Bibliography

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables SNAP receptor activity  
    enables SNAP receptor activity  
    enables SNAP receptor activity PubMed 
    enables SNARE binding  
    enables SNARE binding PubMed 
    enables protein homodimerization activity PubMed 
    Process Evidence Code Pubs
    involved_in copper ion homeostasis PubMed 
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport  
    involved_in exocytosis PubMed 
    involved_in intracellular copper ion homeostasis PubMed 
    involved_in intracellular protein transport  
    involved_in intracellular protein transport  
    involved_in larval lymph gland hemopoiesis PubMed 
    involved_in male meiosis cytokinesis PubMed 
    involved_in spermatogenesis PubMed 
    involved_in vesicle docking  
    involved_in vesicle fusion  
    involved_in vesicle-mediated transport  
    Component Evidence Code Pubs
    located_in Golgi apparatus PubMed 
    is_active_in Golgi membrane  
    located_in Golgi membrane  
    part_of SNARE complex  
    part_of SNARE complex PubMed 
    located_in cis-Golgi network PubMed 
    located_in endomembrane system PubMed 
    is_active_in endomembrane system  
    located_in endoplasmic reticulum  
    located_in membrane  

    General protein information

    Preferred Names
    syntaxin 5
    Names
    CG4214-PA
    CG4214-PB
    Syntaxin5
    Syx5-PA
    Syx5-PB
    dSyntaxin5
    lethal(2)35Ff
    syntaxin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      16307346..16309274
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_134305.3 → NP_599132.2  syntaxin 5, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_599132.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24509, Q7KW50, Q8T9C1
      UniProtKB/TrEMBL
      A4V0S1
      Related
      FBpp0080390
      Conserved Domains (1) summary
      cd15844
      Location:379 → 451
      SNARE_syntaxin5; SNARE motif of syntaxin 5
    2. NM_078858.5 → NP_523582.4  syntaxin 5, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523582.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24509, Q7KW50, Q8T9C1
      UniProtKB/TrEMBL
      A4V0S1
      Related
      FBpp0080389
      Conserved Domains (1) summary
      cd15844
      Location:379 → 451
      SNARE_syntaxin5; SNARE motif of syntaxin 5
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