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    TRX1 thioredoxin TRX1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850732, updated on 9-Dec-2024

    Summary

    Official Symbol
    TRX1
    Official Full Name
    thioredoxin TRX1
    Primary source
    SGD:S000004033
    Locus tag
    YLR043C
    See related
    AllianceGenome:SGD:S000004033; FungiDB:YLR043C; VEuPathDB:YLR043C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    LMA1
    Summary
    Enables disulfide oxidoreductase activity. Involved in several processes, including Golgi vesicle transport; cell redox homeostasis; and vacuole organization. Located in cytosol and mitochondrial intermembrane space. Orthologous to human TXN (thioredoxin). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See TRX1 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (231702..232013, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Afb1p Neighboring gene Nfg1p Neighboring gene indolepyruvate decarboxylase 1 Neighboring gene Stu2p

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by SGD

    Component Evidence Code Pubs
    located_in Golgi apparatus  
    located_in Golgi membrane  
    located_in cytoplasm  
    located_in cytosol PubMed 
    located_in cytosol PubMed 
    located_in cytosol PubMed 
    located_in membrane  
    located_in mitochondrial intermembrane space PubMed 
    located_in mitochondrial intermembrane space  
    located_in mitochondrion PubMed 
    located_in mitochondrion  
    located_in nucleus PubMed 
    located_in nucleus  

    General protein information

    Preferred Names
    thioredoxin TRX1
    NP_013144.1
    • Cytoplasmic thioredoxin isoenzyme; part of the thioredoxin system that protects cells from oxidative and reductive stress; subunit of the LMA1 complex, with Pbi2p, that promotes vacuole inheritance; cofactor for Tsa1p; required for ER-Golgi transport; facilitates mitochondrial import of small Tims (Tim9p, Tim10p, Tim13p) by maintaining them in reduced form along with Trx2p; component of a signal transduction redox relay in a light sensing pathway; abundance increases under DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      231702..232013 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181930.1 → NP_013144.1  TPA: thioredoxin TRX1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013144.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VY45, P22217
      UniProtKB/TrEMBL
      A7A0U8, B3LT14, C7GU47, C8ZD15, G2WIN5, N1P7P9
      Conserved Domains (1) summary
      TIGR01068
      Location:6 → 103
      thioredoxin
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