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    SAS10 rRNA-processing protein SAS10 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851403, updated on 9-Dec-2024

    Summary

    Official Symbol
    SAS10
    Official Full Name
    rRNA-processing protein SAS10
    Primary source
    SGD:S000002312
    Locus tag
    YDL153C
    See related
    AllianceGenome:SGD:S000002312; FungiDB:YDL153C; VEuPathDB:YDL153C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    UTP3
    Summary
    Involved in endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); and endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in nucleolus. Part of small-subunit processome. Orthologous to human UTP3 (UTP3 small subunit processome component). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See SAS10 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (181186..183018, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene B-type cyclin CLB3 Neighboring gene MutS family protein MSH5 Neighboring gene DNA-directed RNA polymerase III subunit C53 Neighboring gene autophagy protein ATG9

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by SGD

    Component Evidence Code Pubs
    is_active_in nucleolus  
    located_in nucleolus PubMed 
    located_in nucleolus  
    located_in nucleus PubMed 
    located_in nucleus  
    part_of ribonucleoprotein complex  
    part_of small-subunit processome  
    part_of small-subunit processome PubMed 

    General protein information

    Preferred Names
    rRNA-processing protein SAS10
    NP_010128.1
    • Subunit of U3-containing Small Subunit (SSU) processome complex; involved in production of 18S rRNA and assembly of small ribosomal subunit; disrupts silencing when overproduced; mutant has increased aneuploidy tolerance; essential gene

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      181186..183018 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180213.1 → NP_010128.1  TPA: rRNA-processing protein SAS10 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010128.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRJ7, Q05842, Q12136
      UniProtKB/TrEMBL
      A6ZXH6, B3LH41, C8Z6F0, G2WC10, N1P7M2
      Conserved Domains (2) summary
      pfam04000
      Location:220 → 296
      Sas10_Utp3; Sas10/Utp3/C1D family
      pfam09368
      Location:534 → 608
      Sas10; Sas10 C-terminal domain
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