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    beta-Spec beta Spectrin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32746, updated on 9-Dec-2024

    Summary

    Official Symbol
    beta-Specprovided by FlyBase
    Official Full Name
    beta Spectrinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0250788
    Locus tag
    Dmel_CG5870
    See related
    AllianceGenome:FB:FBgn0250788
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:fe1B3; b spectrin; b-Spec; B-spec; beta; beta-spec; beta-spectrin; betaHeavy-Spec; betaspec; betaSpec; CG5870; Dmel\CG5870; i168; i6; kus; l(1)G0074; l(1)G0108; l(1)G0198; Spec; Spec-beta; SPEC8; Specbeta; Spectrin
    Summary
    Enables ankyrin binding activity; microtubule binding activity; and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in several processes, including axon guidance; long-term strengthening of neuromuscular junction; and maintenance of presynaptic active zone structure. Located in several cellular components, including fusome; lateral plasma membrane; and spectrosome. Is expressed in several structures, including adult head; adult heart; epithelium; gut section; and larval muscle cell. Used to study spinocerebellar ataxia type 5. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 14; hereditary spherocytosis; hereditary spherocytosis type 2; and spinocerebellar ataxia type 5. Orthologous to several human genes including SPTBN1 (spectrin beta, non-erythrocytic 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See beta-Spec in Genome Data Viewer
    Location:
    16B10-16B12; 1-57 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (17657372..17669371)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (17551405..17563404)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein p190 Neighboring gene Integrator 2 Neighboring gene uncharacterized protein Neighboring gene chascon Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables actin binding  
    enables actin filament binding  
    enables ankyrin binding PubMed 
    enables microtubule binding PubMed 
    enables phosphatidylinositol-4,5-bisphosphate binding PubMed 
    enables phospholipid binding  
    enables structural constituent of cytoskeleton  
    Component Evidence Code Pubs
    located_in axon PubMed 
    is_active_in cell junction  
    is_active_in cell projection  
    is_active_in cortical actin cytoskeleton  
    located_in fusome PubMed 
    located_in lateral plasma membrane PubMed 
    located_in neuromuscular junction PubMed 
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 
    part_of spectrin  
    located_in spectrosome PubMed 

    General protein information

    Preferred Names
    beta spectrin
    Names
    CG5870-PA
    CG5870-PB
    CG5870-PC
    anon-fast-evolving-1B3
    beta-III-Spectrin
    beta-Spec-PA
    beta-Spec-PB
    beta-Spec-PC
    beta-spectrin
    karussell
    spectrin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      17657372..17669371
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272732.1 → NP_001259661.1  beta spectrin, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259661.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PHG4
      Conserved Domains (4) summary
      smart00150
      Location:422 → 521
      SPEC; Spectrin repeats
      cd00176
      Location:639 → 846
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00307
      Location:170 → 269
      CH; Calponin homology (CH) domain
      pfam00435
      Location:2018 → 2078
      Spectrin; Spectrin repeat
    2. NM_078664.3 → NP_523388.1  beta spectrin, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523388.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q00963, Q6NNX2, Q9VX30
      Related
      FBpp0074228
      Conserved Domains (6) summary
      smart00150
      Location:422 → 521
      SPEC; Spectrin repeats
      cd00176
      Location:639 → 846
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd10571
      Location:2150 → 2257
      PH_beta_spectrin; Beta-spectrin pleckstrin homology (PH) domain
      pfam00169
      Location:2150 → 2258
      PH; PH domain
      pfam00307
      Location:170 → 269
      CH; Calponin homology (CH) domain
      pfam00435
      Location:2018 → 2078
      Spectrin; Spectrin repeat
    3. NM_001272731.1 → NP_001259660.1  beta spectrin, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259660.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PF16
      Conserved Domains (6) summary
      smart00150
      Location:422 → 521
      SPEC; Spectrin repeats
      cd00176
      Location:639 → 846
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd10571
      Location:2167 → 2274
      PH_beta_spectrin; Beta-spectrin pleckstrin homology (PH) domain
      pfam00169
      Location:2167 → 2275
      PH; PH domain
      pfam00307
      Location:170 → 269
      CH; Calponin homology (CH) domain
      pfam00435
      Location:2018 → 2078
      Spectrin; Spectrin repeat
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