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    TCA17 Tca17p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856663, updated on 4-Jan-2025

    Summary

    Official Symbol
    TCA17
    Official Full Name
    Tca17p
    Primary source
    SGD:S000000774
    Locus tag
    YEL048C
    See related
    AllianceGenome:SGD:S000000774; FungiDB:YEL048C; VEuPathDB:YEL048C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in early endosome to Golgi transport and protein-containing complex assembly. Located in Golgi apparatus. Part of TRAPPII protein complex. Used to study myoclonic-atonic epilepsy and rhabdomyolysis-myalgia syndrome. [provided by Alliance of Genome Resources, Jan 2025]
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    Genomic context

    See TCA17 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (64709..65167, complement)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene tRNA-Gly Neighboring gene seripauperin PAU2 Neighboring gene fumarate reductase Neighboring gene threonine aldolase GLY1

    Interactions

    General gene information

    Gene Ontology Provided by SGD

    Component Evidence Code Pubs
    located_in Golgi apparatus PubMed 
    located_in Golgi apparatus  
    part_of TRAPP complex  
    part_of TRAPPII protein complex PubMed 
    is_active_in cytoplasm  
    located_in cytosol PubMed 
    is_active_in nucleus  
    part_of protein-containing complex  

    General protein information

    Preferred Names
    Tca17p
    NP_010866.1
    • Component of transport protein particle (TRAPP) complex II; TRAPPII is a multimeric guanine nucleotide-exchange factor for the GTPase Ypt1p, regulating intra-Golgi and endosome-Golgi traffic; promotes association of TRAPPII-specific subunits with the TRAPP core complex; sedlin related; human Sedlin mutations cause SEDT, a skeletal disorder

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      64709..65167 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178863.1 → NP_010866.1  TPA: Tca17p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010866.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLK2, P32613, Q6Q561
      UniProtKB/TrEMBL
      A6ZQQ3, B3LRW9, C7GKF0, C8Z6U6, G2WCI6, N1P3R1
      Conserved Domains (1) summary
      cl21566
      Location:10 → 143
      Sedlin_N; Sedlin, N-terminal conserved region
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