Lrt Leucine-rich tendon-specific protein [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Lrtprovided by FlyBase
Official Full Name: Leucine-rich tendon-specific proteinprovided by FlyBase
Primary source: FLYBASE:FBgn0034540
Locus tag: Dmel_CG11136
See related: AllianceGenome:FB:FBgn0034540
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG11136; CT31131; Dmel\CG11136; lrt; tartan/capricious-like
Summary: Involved in Roundabout signaling pathway and negative regulation of muscle cell chemotaxis toward tendon cell. Located in muscle tendon junction and plasma membrane. Part of protein-containing complex. Is expressed in several structures, including amnioserosa; amnioserosa anlage; anlage in statu nascendi; epidermis; and head epidermis primordium. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 57A9-57A9; 2-91 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (20646360..20661070)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (16533865..16548575)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Slit2 may promote angiogenesis by upregulating Robo1 and activating the VEGFR2-ERK1/2 pathway.
Title: Slit2 Promotes Angiogenic Activity Via the Robo1-VEGFR2-ERK1/2 Pathway in Both In Vivo and In Vitro Studies.
These results suggest a novel mechanism of intercellular recognition through interactions between LRR family members and Robo receptors.
Title: Fine tuning cellular recognition: The function of the leucine rich repeat (LRR) trans-membrane protein, LRT, in muscle targeting to tendon cells.
Due to its distribution CG11136 protein was named ;Leucine-rich tendon-specific protein' (LRT); study shows that LRT forms a protein complex with Robo, these proteins interact, thereby affecting the extent of muscle extension towards tendon cells.
Title: LRT, a tendon-specific leucine-rich repeat protein, promotes muscle-tendon targeting through its interaction with Robo.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Roundabout signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of muscle cell chemotaxis toward tendon cell	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in muscle tendon junction	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: Leucine-rich tendon-specific protein

Names: CG11136-PB; CG11136-PC; Lrt-PB; Lrt-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

20646360..20661070

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_137662.4 → NP_611506.2 Leucine-rich tendon-specific protein, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_611506.2

Status: REVIEWED

UniProtKB/TrEMBL

A1ZBX8, E3CTT8

Conserved Domains (5) summary

smart00082
Location:454 → 504

LRRCT; Leucine rich repeat C-terminal domain

cd00116
Location:248 → 457

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00031
Location:157 → 177

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:227 → 250

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:348 → 406

LRR_8; Leucine rich repeat
NM_001299711.1 → NP_001286640.1 Leucine-rich tendon-specific protein, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001286640.1

Status: REVIEWED

UniProtKB/TrEMBL

D0IQL1, E3CTT8

Conserved Domains (5) summary

smart00082
Location:476 → 526

LRRCT; Leucine rich repeat C-terminal domain

cd00116
Location:270 → 479

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00031
Location:179 → 199

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:249 → 272

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:370 → 428

LRR_8; Leucine rich repeat